2024 Alzheimer’s disease facts and figures. (2024). Alzheimer’s and Dementia, 20(5), 3708–3821. https://doi.org/10.1002/alz.13809

Andorfer, C., Acker, C. M., Kress, Y., Hof, P. R., Duff, K., & Davies, P. (2005). Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. The Journal of Neuroscience, 25(22), 5446–5454. https://doi.org/10.1523/JNEUROSCI.4637-04.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andorfer, C., Kress, Y., Espinoza, M., de Silva, R., Tucker, K. L., Barde, Y.-A., Duff, K., & Davies, P. (2003). Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. Journal of Neurochemistry, 86(3), 582–590. https://doi.org/10.1046/j.1471-4159.2003.01879.x

Article  CAS  PubMed  Google Scholar 

Arakhamia, T., Lee, C. E., Carlomagno, Y., Kumar, M., Duong, D. M., Wesseling, H., Kundinger, S. R., Wang, K., Williams, D., DeTure, M., Dickson, D. W., Cook, C. N., Seyfried, N. T., Petrucelli, L., Steen, J. A., & Fitzpatrick, A. W. P. (2021). Posttranslational modifications mediate the structural diversity of tauopathy strains. Cell, 184(25), 6207–6210. https://doi.org/10.1016/j.cell.2021.11.029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baas, P. W., & Qiang, L. (2019). Tau: It’s not what you think. Trends in Cell Biology, 29(6), 452–461. https://doi.org/10.1016/j.tcb.2019.02.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bankhead, P., Loughrey, M. B., Fernández, J. A., Dombrowski, Y., McArt, D. G., Dunne, P. D., McQuaid, S., Gray, R. T., Murray, L. J., Coleman, H. G., James, J. A., Salto-Tellez, M., & Hamilton, P. W. (2017). QuPath: Open source software for digital pathology image analysis. Scientific Reports, 7(1), 16878. https://doi.org/10.1038/s41598-017-17204-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braak, H., & Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica, 82(4), 239–259. https://doi.org/10.1007/BF00308809

Article  CAS  PubMed  Google Scholar 

Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., Grisoli, M., Savoiardo, M., Spillantini, M. G., Tagliavini, F., Goedert, M., & Ghetti, B. (1999). Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. Journal of Neuropathology and Experimental Neurology, 58(6), 667–677. https://doi.org/10.1097/00005072-199906000-00011

Article  CAS  PubMed  Google Scholar 

Clavaguera, F., Akatsu, H., Fraser, G., Crowther, R. A., Frank, S., Hench, J., Probst, A., Winkler, D. T., Reichwald, J., Staufenbiel, M., Ghetti, B., Goedert, M., & Tolnay, M. (2013). Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9535–9540. https://doi.org/10.1073/pnas.1301175110

Article  PubMed  PubMed Central  Google Scholar 

Cleveland, D. W., Hwo, S. Y., & Kirschner, M. W. (1977a). Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. Journal of Molecular Biology, 116(2), 227–247. https://doi.org/10.1016/0022-2836(77)90214-5

Article  CAS  PubMed  Google Scholar 

Cleveland, D. W., Hwo, S. Y., & Kirschner, M. W. (1977b). Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. Journal of Molecular Biology, 116(2), 207–225. https://doi.org/10.1016/0022-2836(77)90213-3

Article  CAS  PubMed  Google Scholar 

Drubin, D. G., & Kirschner, M. W. (1986). Tau protein function in living cells. The Journal of Cell Biology, 103(6 Pt 2), 2739–2746. https://doi.org/10.1083/jcb.103.6.2739

Article  CAS  PubMed  Google Scholar 

Dujardin, S., Commins, C., Lathuiliere, A., Beerepoot, P., Fernandes, A. R., Kamath, T. V, De Los Santos, M. B., Klickstein, N., Corjuc, D. L., Corjuc, B. T., Dooley, P. M., Viode, A., Oakley, D. H., Moore, B. D., Mullin, K., Jean-Gilles, D., Clark, R., Atchison, K., Moore, R., … Hyman, B. T. (2020). Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease. Nature Medicine, 26(8), 1256–1263. https://doi.org/10.1038/s41591-020-0938-9

Dujardin, S., Begard, S., Caillierez, R., Lachaud, C., Carrier, S., Lieger, S., Gonzalez, J. A., Deramecourt, V., Deglon, N., Maurage, C. A., Frosch, M. P., Hyman, B. T., Colin, M., & Buee, L. (2018). Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathologica Communications, 6(1), 132. https://doi.org/10.1186/s40478-018-0637-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumanchin, C., Camuzat, A., Campion, D., Verpillat, P., Hannequin, D., Dubois, B., Saugier-Veber, P., Martin, C., Penet, C., Charbonnier, F., Agid, Y., Frebourg, T., & Brice, A. (1998). Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism. Human Molecular Genetics, 7(11), 1825–1829. https://doi.org/10.1093/hmg/7.11.1825

Article  CAS  PubMed  Google Scholar 

Erro, M. E., Zelaya, M. V., Mendioroz, M., Larumbe, R., Ortega-Cubero, S., Lanciego, J. L., Lladó, A., Cabada, T., Tuñón, T., García-Bragado, F., Luquin, M. R., Pastor, P., & Ferrer, I. (2019). Globular glial tauopathy caused by MAPT P301T mutation: Clinical and neuropathological findings. Journal of Neurology, 266(10), 2396–2405. https://doi.org/10.1007/s00415-019-09414-w

Article  CAS  PubMed  Google Scholar 

Ferrari, A., Hoerndli, F., Baechi, T., Nitsch, R. M., & Götz, J. (2003). beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. The Journal of Biological Chemistry, 278(41), 40162–40168. https://doi.org/10.1074/jbc.M308243200

Article  CAS  PubMed  Google Scholar 

Forman, M. S., Lal, D., Zhang, B., Dabir, D. V., Swanson, E., Lee, V.M.-Y., & Trojanowski, J. Q. (2005). Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. The Journal of Neuroscience, 25(14), 3539–3550. https://doi.org/10.1523/JNEUROSCI.0081-05.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V.M.-Y. (2003). Initiation and synergistic fibrillization of tau and alpha-synuclein. Science, 300(5619), 636–640. https://doi.org/10.1126/science.1082324

Article  CAS  PubMed  Google Scholar 

Goedert, M., Crowther, R. A., Scheres, S. H. W., & Spillantini, M. G. (2024). Tau and neurodegeneration. Cytoskeleton, 81(1), 95–102. https://doi.org/10.1002/cm.21812

Article  CAS  PubMed  Google Scholar 

Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017). Propagation of Tau aggregates and neurodegeneration. Annual Review of Neuroscience, 40, 189–210. https://doi.org/10.1146/annurev-neuro-072116-031153

Article  CAS  PubMed  Google Scholar 

Goedert, M., & Jakes, R. (1990). Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization. The EMBO Journal, 9(13), 4225–4230. https://doi.org/10.1002/j.1460-2075.1990.tb07870.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Götz, J., Probst, A., Spillantini, M. G., Schäfer, T., Jakes, R., Bürki, K., & Goedert, M. (1995). Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. The EMBO Journal, 14(7), 1304–1313. https://doi.org/10.1002/j.1460-2075.1995.tb07116.x

Article  PubMed  PubMed Central  Google Scholar 

Guo, J. L., Narasimhan, S., Changolkar, L., He, Z., Stieber, A., Zhang, B., Gathagan, R. J., Iba, M., McBride, J. D., Trojanowski, J. Q., & Lee, V. M. (2016). Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice. Journal of Experimental Medicine, 213(12), 2635–2654. https://doi.org/10.1084/jem.20160833

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M., & Mandelkow, E. M. (1994). Domains of tau protein and interactions with microtubules. Biochemistry, 33(32), 9511–9522. https://doi.org/10.1021/bi00198a017

Article  CAS  PubMed  Google Scholar 

He, Z., McBride, J. D., Xu, H., Changolkar, L., Kim, S.-J., Zhang, B., Narasimhan, S., Gibbons, G. S., Guo, J. L., Kozak, M., Schellenberg, G. D., Trojanowski, J. Q., & Lee, V.M.-Y. (2020). Transmission of tauopathy strains is independent of their isoform composition. Nature Communications, 11(1), 7. https://doi.org/10.1038/s41467-019-13787-x

Article  CAS  PubMed  PubMed Central