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Making the primate cortex ‘see’ with mesoscale optogenetics
In this Tools of the Trade article, Hao Li describes the development of a mesoscale optogenetics platform for targeted and...
A social readout of circuit imbalance
In this Journal Club, Baolin Guo highlights a 2011 study that linked altered excitation–inhibition balance in prefro...
Wired for immunity: neuroimmune control of the lung by sensory neurons
Wired for immunity: neuroimmune control of the lung by sensory neurons
Respiratory diseases, including bacterial pneumonia, viral infections and allergic asthma, are leading causes of hospitali...
Large-scale electrophysiology at single-spike resolution
Large-scale electrophysiology at single-spike resolution
Recent advances in electrode technology — including the development of Neuropixels and SiNAPS probes — have ma...
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network
Mammalian sensory systems are traditionally viewed as hierarchical pathways in which subcortical nuclei relay signals from...
Mapping the molecular effects of Down syndrome in the developing brain
Two studies use single-nucleus multiomic sequencing to profile molecular and cellular dysfunction in the prenatal and earl...
Linking the exposome to the brain–behaviour phenotype
Linking the exposome to the brain–behaviour phenotype
A range of environmental, lifestyle and biological exposures across the lifespan — varying in timing, duration and i...
Neural basis of social hierarchy across species
Neural basis of social hierarchy across species
A social hierarchy is an ordered ranking of individuals that arises through their interactions and governs relative access...
Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation
Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation
Anxiety and stress-related psychiatric disorders are highly prevalent, have uncertain aetiologies and are only partially r...
Going offline to enhance memory during sleep
In this Journal Club, Edwin Robertson discusses a study published in 2000 that found a link between sleep and enhancement ...
Multisensory coding of self-motion and its contribution to navigation
Multisensory coding of self-motion and its contribution to navigation
Mobile organisms integrate multimodal self-motion signals — including motor commands, vestibular inputs, optic flow ...
Ripple contributions to human memory: making the spiking content count
Ripple contributions to human memory: making the spiking content count
Memories shape our sense of self and enable adaptive behaviour based on prior experiences, yet the neural mechanisms under...
Twenty-five years of covering neuroscience
In this issue, we mark the 25th anniversary of Nature Reviews Neuroscience.
Brain connectivity benefits from enriched environments
The diverse sensory input provided by physically and socially enriched environments is shown in mice to increase sensory i...
Cellular responses to repetitive head trauma
Single-nucleus RNA sequencing reveals early cellular responses in young atheletes exposed to repetitive head impacts that ...
Grid cells go local
A new study finds that grid cells track a mouse’s position in local reference frames instead of a global frame of re...
Circuit control of competition
A study explores the circuits through which the dorsolateral prefrontal cortex orchestrates social competition in mice.
Neural compositions use multigoal building blocks
A new study reveals an algorithm implemented by neurons in the medial frontal cortex that is involved in flexibly mapping ...
Schemas, reinforcement learning and the medial prefrontal cortex
Schemas, reinforcement learning and the medial prefrontal cortex
Schemas are rich and complex knowledge structures about the typical unfolding of events in a context; for example, a schem...
The curious case of dopaminergic prediction errors and learning associative information beyond value
The curious case of dopaminergic prediction errors and learning associative information beyond value
Transient changes in the firing of midbrain dopamine neurons have been closely tied to the unidimensional value-based pred...
The short and long pathways to memory
Inhibition of CaMKII blocks short-term memory but not long-term memory of inhibitory avoidance in mice.
Human hippocampal circuit characterization
A new study reveals distinct circuit features of the human hippocampal CA3 region.
Pathways to sex preferences
A study explores the sexually dimorphic circuits that regulate sociosexual preferences in mice.
Early spinal cord development: from neural tube formation to neurogenesis
Early spinal cord development: from neural tube formation to neurogenesis
As one of the simplest and most evolutionarily conserved parts of the vertebrate nervous system, the spinal cord serves as...
Preparing for motherhood
In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.
The neurobiology of SARS-CoV-2 infection
The neurobiology of SARS-CoV-2 infection
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected de...
The long COVID haul
Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 i...
The generative grammar of the brain: a critique of internally generated representations
The generative grammar of the brain: a critique of internally generated representations
The past decade of progress in neurobiology has uncovered important organizational principles for network preconfiguration...
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep is considered essential for the brain and body. A predominant concept is that sleep is regulated by circadian rhythm...
From local APP expression to network dysfunction
In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippoc...
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