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Scale for Ocular Motor Disorders in Ataxia (SODA) in Patients with Multiple System Atrophy
Scale for Ocular Motor Disorders in Ataxia (SODA) in Patients with Multiple System Atrophy
A clinical scale fully dedicated to evaluating ocular motor abnormalities is required for now. We investigated the utility...
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
Mobility limitations, including a decrease in walking speed, are major issues for people with autosomal recessive spastic ...
Cerebellar Direct Current Stimulation Reveals the Causal Role of the Cerebellum in Temporal Prediction
Cerebellar Direct Current Stimulation Reveals the Causal Role of the Cerebellum in Temporal Prediction
Temporal prediction (TP) influences our perception and cognition. The cerebellum could mediate this multi-level ability in...
Cerebellar Asymmetry of Motivational Direction: Anger-Dependent Effects of Cerebellar Transcranial Direct Current Stimulation on Aggression in Healthy Volunteers
Cerebellar Asymmetry of Motivational Direction: Anger-Dependent Effects of Cerebellar Transcranial Direct Current Stimulation on Aggression in Healthy Volunteers
It has recently been theorized that the frontal asymmetry of approach- and avoidance-related motivation is mirrored in the...
The Phenotypic Spectrum of Spinocerebellar Ataxia Type 19 in a Series of Latin American Patients
The Phenotypic Spectrum of Spinocerebellar Ataxia Type 19 in a Series of Latin American Patients
Spinocerebellar ataxia 19 (SCA19) represents a rare autosomal dominant genetic disorder resulting in progressive ataxia an...
Patient-Related Outcome Measures for Oculomotor Symptoms in the Cerebellar Ataxias: Insights from Non-Cerebellar Disorders
Patient-Related Outcome Measures for Oculomotor Symptoms in the Cerebellar Ataxias: Insights from Non-Cerebellar Disorders
In patients with cerebellar ataxia (CA), symptoms related to oculomotor dysfunction significantly affect quality of life (...
Early-Life Social Determinants of SCA6 Age at Onset, Severity, and Progression
Early-Life Social Determinants of SCA6 Age at Onset, Severity, and Progression
SCA6 patients with the same size CAG repeat allele can vary significantly in age at onset (AAO) and clinical progression. ...
Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases
Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases
Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, b...
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Recent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, sug...
Amyotrophic Lateral Sclerosis with SOD1 Mutation Presenting with Progressive Cerebellar Ataxia
Amyotrophic Lateral Sclerosis with SOD1 Mutation Presenting with Progressive Cerebellar Ataxia
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder that affects upper and lower motor neurons. SOD1 mutat...
Correction: A Novel de novo KIF1A Mutation in a Patient with Ataxia, Intellectual Disability and Mild Foot Deformity
Correction: A Novel de novo KIF1A Mutation in a Patient with Ataxia, Intellectual Disability and Mild Foot Deformity
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition
A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition
The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by compar...
Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series
Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series
Primary autoimmune cerebellar ataxia (PACA) is an idiopathic sporadic cerebellar ataxia that is thought to be immune-media...
AFG3L2 Biallelic Mutation: Clinical Heterogeneity in Two Italian Patients
AFG3L2 Biallelic Mutation: Clinical Heterogeneity in Two Italian Patients
AFG3-like matrix AAA peptidase subunit 2 gene (AFG3L2, OMIM * 604,581) biallelic mutations lead to autosomal recessive spa...
Machado Joseph-Disease Is Rare in the Peruvian Population
Machado Joseph-Disease Is Rare in the Peruvian Population
Spinocerebellar ataxia type 3 or Machado-Joseph disease (MJD/SCA3) is the most prevalent autosomal dominant cerebellar ata...
A Systematic Review on Anti-Yo/PCA-1 Antibody: Beyond Cerebellar Ataxia in Middle-Aged Women with Gynecologic Cancer
A Systematic Review on Anti-Yo/PCA-1 Antibody: Beyond Cerebellar Ataxia in Middle-Aged Women with Gynecologic Cancer
Current understanding of anti-Yo/PCA1 antibody-associated cerebellar ataxia is based on case reports and small case series...
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta‑analysis of Randomized Controlled Trials
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta‑analysis of Randomized Controlled Trials
Therapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulatio...
Monocular Torsional Oscillopsia in Dentato-olivary Disconnection
Monocular Torsional Oscillopsia in Dentato-olivary Disconnection
Monocular torsional eye oscillations are a rare form of disconjugate nystagmus and the underlying pathophysiology is not w...
A Novel Paired Somatosensory-Cerebellar Stimulation Induces Plasticity on Cerebellar-Brain Connectivity
A Novel Paired Somatosensory-Cerebellar Stimulation Induces Plasticity on Cerebellar-Brain Connectivity
The cerebellum receives and integrates a large amount of sensory information that is important for motor coordination and ...
The Frequency of Intermediate Alleles in Patients with Cerebellar Phenotypes
The Frequency of Intermediate Alleles in Patients with Cerebellar Phenotypes
Cerebellar syndromes are clinically and etiologically heterogeneous and can be classified as hereditary, neurodegenerative...
Relationship of Morphometrics and Symptom Severity in Female Type I Chiari Malformation Patients with Biological Resilience
Relationship of Morphometrics and Symptom Severity in Female Type I Chiari Malformation Patients with Biological Resilience
In the present study we report the relationship among MRI-based skull and cervical spine morphometric measures as well as ...
Patient-Reported Outcome Measure of Ataxia Correlates with Canonical Clinical Assessments in Chinese Spinocerebellar Ataxias
Patient-Reported Outcome Measure of Ataxia Correlates with Canonical Clinical Assessments in Chinese Spinocerebellar Ataxias
Spinocerebellar ataxia (SCA) patients’ reports of their own experiences are essential to the outcome evaluation in c...
The Neuroimmune System and the Cerebellum
The Neuroimmune System and the Cerebellum
The recognition that there is an innate immune system of the brain, referred to as the neuroimmune system, that preforms m...
“Hot Cross Bun” Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature
“Hot Cross Bun” Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature
The “hot cross bun” sign (HCBs) is a cruciform hyperintensity on T2-weighted imaging within the pons initially...
Diagnostic Yield of NGS Tests for Hereditary Ataxia: a Systematic Review
Diagnostic Yield of NGS Tests for Hereditary Ataxia: a Systematic Review
Next-generation sequencing (NGS), comprising targeted panels (TP), exome sequencing (ES), and genome sequencing (GS) becam...
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital healt...
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band—a Narrative Review
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band—a Narrative Review
The cerebellum plays an important role in maintaining balance, posture control, muscle tone, and lower limb coordination i...
NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse
NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse
As an excitatory neuron in the cerebellum, the granule cells play a crucial role in motor learning. The assembly of NMDAR ...
Therapeutic Biomarkers in Friedreich’s Ataxia: a Systematic Review and Meta-analysis
Therapeutic Biomarkers in Friedreich’s Ataxia: a Systematic Review and Meta-analysis
Although a large array of biomarkers have been investigated in Friedreich’s ataxia (FRDA) trials, the optimal biomar...
Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation
Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation
Spinocerebellar ataxia (SCA)19/22 is a channelopathy caused by mutations in the KCND3 gene encoding for the voltage-gated ...
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