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Microglial histone deacetylase-3 conditional deletion attenuates neurological deficits after intracerebral hemorrhage
Stimulation of the innate immune system after intracerebral hemorrhage (ICH), characterized by microglial activation, cont...
CircFRRS1 drives neuroinflammation through the miR-27a-3p/TLR4 pathway after deep hypothermic circulatory arrest
Neurologic injury remains a critical complication of deep hypothermic circulatory arrest (DHCA) in aortic arch surgery, wi...
Molecular mechanisms underlying the ferroptosis-induced epileptiform activity in mouse cortical slices
IntroductionFerroptosis, a newly defined iron-dependent programmed cell death, characterized by excessive accumulation of ...
Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome
Down syndrome is the most common genetic neurodevelopmental disorder associated with mild-to-moderate intellectual disabil...
Editorial: Interneurons in pathological conditions
Down syndrome is the most common genetic cause of intellectual disability. Individuals face elevated risks for epilepsy an...
Anxiety is associated with systemic pro-inflammatory profile and plasma lipid changes in Mexican young adults
IntroductionSystemic inflammation and altered lipid metabolism have been implicated in anxiety disorders, but the relation...
Personalized resilience: how individual variability in brain–immune responses to stress influences the development of anxiety disorders
Stress exposure has increased significantly, contributing to higher rates of anxiety, depression, and post-traumatic stres...
Peri-implantitis derived extracellular vesicle as vectors of neuroinflammation
Peri-implantitis (PI) results from biofilm accumulation on implant-supported crowns and/or implants coils, triggering an i...
From metabolism to mood regulation: astrocytes as a driver of depression
Astrocytes are increasingly recognized as active regulators of mood and cognition, extending far beyond their classical su...
Developmental stage–dependent neurotoxicity of sevoflurane: evidence from brain organoids
Sevoflurane is widely used in pediatric anesthesia because it allows rapid induction and recovery, yet its use during vuln...
Molecular and developmental insights into proprioceptive identity in the mesencephalic trigeminal nucleus neurons
The mesencephalic trigeminal nucleus (MTN) contains trigeminal proprioceptive neurons, a unique class of primary sensory n...
Predicting stroke-associated infection in acute ischemic stroke patients treated by thrombolysis
BackgroundAcute ischemic stroke (AIS) remains one of the major contributors to mortality and disability worldwide. Stroke-...
Focal cortical dysplasias: modeling pediatric drug-resistant epilepsy using human brain organoids
Epilepsy is a prevalent neurological disorder characterized by recurrent, unprovoked seizures and altered electroencephalo...
The mesencephalic trigeminal neuron: electrophysiological insights into function and dysfunction
Mesencephalic trigeminal neurons (MTNs) are the sole primary afferent neurons with cell bodies located within the central ...
Silencing MALAT1 represses pathological progression, inflammation, and vascular smooth muscle cell phenotype switching by regulating the SEMA3C-mediated Smad pathway in intracranial aneurysms
BackgroundThe crucial role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in regulating aneurysm forma...
Microglia-derived metabolites as novel signaling molecules: regulating neural circuit function, behavior, and their role in psychiatric disorders
Microglia, central immune and metabolic regulators, release metabolites that act as signaling molecules into the interstit...
Reduced peripheral serotonin levels in women with multiple sclerosis: associations with underweight status, treatment duration, and use of interferon beta 1a
Multiple sclerosis (MS) is a chronic autoimmune-mediated demyelinating disease of the CNS, characterized by neuroinflammat...
Preclinical models of stem cell-mediated analgesia and tissue repair: mechanisms, challenges, and future directions
As an emerging biological therapeutic approach, stem cell therapy demonstrates broad application prospects in analgesia an...
Function of the large intestine and its interaction with the brain after ischemic stroke: a comprehensive literature review
The large intestine, part of the distal gastrointestinal tract, is vital for water and electrolyte absorption and microbia...
Neurovascular dysfunction in the development and progression of neuroinflammatory diseases
The neurovascular unit (NVU) is critical for brain homeostasis through its roles in maintenance of an effective blood brai...
Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses
Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses
Noise-induced cochlear synaptopathy is characterized by irreversible loss of synapses between inner hair cells (IHCs) and ...
A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo
A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo
Potassium channel mutations play an important role in neurological diseases, such as spinocerebellar ataxia (SCA). SCA is ...
Loss of C1q alters the auditory brainstem response
Loss of C1q alters the auditory brainstem response
Neural circuits in the auditory brainstem compute interaural time and intensity differences used to determine the location...
Editorial: Neuromodulation technology: advances in optics and acoustics
It is estimated that about 43.3 million people are blind and 295 million with moderate to severe visual impairment worldwi...
Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review
Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review
Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their abilit...
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Voltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. Wh...
Organoid intelligence for developmental neurotoxicity testing
Organoid intelligence for developmental neurotoxicity testing
The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determi...
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functio...
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
BackgroundThe impact of maternal surgery combined with general anesthesia on neuroinflammation and the development of lear...
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease (AD) is a devastating neurodegenerative condition that affects memory and cognition, characterized by ...
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