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Dorsal Column Nuclei at the Core of TENS: Circuit Principles and Outlook for Neuropathic Pain Therapy
Dorsal Column Nuclei at the Core of TENS: Circuit Principles and Outlook for Neuropathic Pain Therapy
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D. Neuropathic pain. Nat Rev Dis Primers 2017, 3: 1700...
Current Advances and Applications of Retinal Organoids
Current Advances and Applications of Retinal Organoids
Retinal organoids (ROs) are three-dimensional in vitro models that replicate the specific cellular composition and inner s...
Putting the Brakes on Thirst: A Neural Circuit for Anticipatory Fluid Control
Putting the Brakes on Thirst: A Neural Circuit for Anticipatory Fluid Control
Zimmerman CA, Leib DE, Knight ZA. Neural circuits underlying thirst and fluid homeostasis. Nat Rev Neurosci 2017, 18: 459–...
Comparison of Freeze-drying and Gradient Dehydration Treatment on X-ray Imaging for Three-dimensional Reconstruction of Early Human Embryonic Brain Samples
Comparison of Freeze-drying and Gradient Dehydration Treatment on X-ray Imaging for Three-dimensional Reconstruction of Early Human Embryonic Brain Samples
Shan L, Yuan L, Zhang B, Ma J, Xu X, Gu F. Neural integration of audiovisual sensory inputs in macaque amygdala and adjace...
Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI
Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI
Astrocytes have long been considered passive players in brain function, yet emerging evidence suggests they actively modul...
Reactive OPCs in CNS Injury: From Functional Diversity to Therapeutic Translation
Reactive OPCs in CNS Injury: From Functional Diversity to Therapeutic Translation
Central nervous system (CNS) injuries trigger a complex glial response, in which oligodendrocyte precursor cells (OPCs) pl...
Role Shift of Glial Cells from Physiology to Pathology in Alzheimer’s Disease: The Regulatory Impact of Exercise
Role Shift of Glial Cells from Physiology to Pathology in Alzheimer’s Disease: The Regulatory Impact of Exercise
Alzheimer’s disease (AD) is a widespread neurodegenerative condition with cognitive and behavioral decline. Astrocyt...
Unveiling a Novel Mechanism in Noise-Induced Hearing Loss: Oxeiptosis-Mediated Regulated Cell Death of Cochlear Hair Cell
Unveiling a Novel Mechanism in Noise-Induced Hearing Loss: Oxeiptosis-Mediated Regulated Cell Death of Cochlear Hair Cell
Noise-induced hearing loss is a prevalent form of sensorineural hearing impairment that negatively impacts quality of life...
Cortical Contributions to Local and Global Biological Motion Perception: Insights from Transcranial Magnetic Stimulation
Cortical Contributions to Local and Global Biological Motion Perception: Insights from Transcranial Magnetic Stimulation
Troje NF, Chang DHF. Shape-independent processing of biological motion. In: People watching: Social, perceptual, and neuro...
Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression
Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression
Li J, Wang YJ, Liu XL, Zhang Y, Zhu XN, Zhao D. Characteristics of time perception in adolescents with non-suicidal self-i...
Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain
Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain
Kainate receptors (KARs) are members of the ionotropic glutamate receptor family and possess diverse structural and functi...
Unconscious Fear Requires Attention to Distort Vision in Safe Context
Unconscious Fear Requires Attention to Distort Vision in Safe Context
Despite widespread exposure to stress and threats, why some develop anxiety while others do not remains unclear. We hypoth...
Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation
Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation
Specialized cutaneous Schwann cells (scSCs) are a recently identified glial class implicated in cutaneous pain modulation,...
Aging-Related Changes in the Injury Response of the Peripheral Nervous System
Aging-Related Changes in the Injury Response of the Peripheral Nervous System
Peripheral nerve injury (PNI) significantly impairs patients’ quality of life, with elderly individuals experiencing...
Ca-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons
Ca-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons
While Katz’s Ca2+ hypothesis has defined that action potentials trigger neurotransmitter release through Ca2+-depend...
Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway
Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway
Endoplasmic reticulum (ER) stress plays a significant role in chronic pain, but its potential involvement in chronic itch ...
Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease
Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease
White matter, constituting nearly half of the human brain, is increasingly recognized as a dynamic regulator of neural com...
Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout
Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout
Gouty arthritis is an autoinflammatory joint disease caused by the deposition of monosodium urate crystals, which activate...
Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia
Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia
Hypothermia is widely acknowledged to exert protective effects against cerebral hypoxic-ischemic injury. Despite ...
Combined Study of Behavior and Spike Discharges Associated with Negative Emotions in Mice
Combined Study of Behavior and Spike Discharges Associated with Negative Emotions in Mice
In modern society, people are increasingly exposed to chronic stress, leading to various mental disorders. However, the ac...
Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting
Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting
Our research reveals the critical role of the suprachiasmatic nucleus (SCN) vasoactive intestinal peptide (VIP) neurons in...
Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses
Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses
Although oligodendrocytes (OLs) are known to form the myelin sheath around neuronal axons for the saltatory conduction of ...
Into the Spotlight: Microglia in the Peripheral Nervous System
Into the Spotlight: Microglia in the Peripheral Nervous System
Prinz M, Jung S, Priller J. Microglia biology: One century of evolving concepts. Cell 2019, 179: 292–311.CAS  PubMed  ...
13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion
13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion
Chronic cerebral hypoperfusion leads to white matter injury (WMI), which plays a significant role in contributing to vascu...
Single-Cell Sequencing Reveals Circadian Sensitivity of Noise-Induced Hearing Loss Mediated by Macrophage-Driven NLRP3 Inflammasome Activation
Single-Cell Sequencing Reveals Circadian Sensitivity of Noise-Induced Hearing Loss Mediated by Macrophage-Driven NLRP3 Inflammasome Activation
Circadian sensitivity significantly influences the severity of noise-induced hearing loss (NIHL), but the underlying mecha...
Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components
Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components
Social working memory (SWM)—the ability to maintain and manipulate social information in the brain—plays a cru...
Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia
Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia
Cerebral ischemia restricts cerebral blood flow (CBF), leading to unstable hemodynamics. Past studies of ischemia mainly f...
Pre-action Neuronal Encoding of Task Situation Uncertainty in the Medial Prefrontal Cortex of Rats
Pre-action Neuronal Encoding of Task Situation Uncertainty in the Medial Prefrontal Cortex of Rats
Humans and animals have a fundamental ability to use experiences and environmental information to organize behavior. It of...
Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques
Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques
The temporal pole (TP), one of the most expanded cortical regions in humans relative to other primates, plays a crucial ro...
CGRP: Does A Novel Neuroimmune Modulator Facilitate Tissue Repair?
CGRP: Does A Novel Neuroimmune Modulator Facilitate Tissue Repair?
Deng L, Gillis JE, Chiu IM, Kaplan DH. Sensory neurons: An integrated component of innate immunity. Immunity 2024, 57: 815...
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