Into the Spotlight: Microglia in the Peripheral Nervous System

Prinz M, Jung S, Priller J. Microglia biology: One century of evolving concepts. Cell 2019, 179: 292–311.

CAS  PubMed  Google Scholar 

Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330: 841–845.

CAS  PubMed  PubMed Central  Google Scholar 

Prinz M, Masuda T, Wheeler MA, Quintana FJ. Microglia and central nervous system-associated macrophages—from origin to disease modulation. Annu Rev Immunol 2021, 39: 251–277.

CAS  PubMed  PubMed Central  Google Scholar 

Wu Z, Wang Y, Chen WW, Sun H, Chen X, Li X, et al. Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. Cell 2025, 188: 2159–2174.e15.

CAS  PubMed  Google Scholar 

Wang Z, Wu Z, Wang H, Feng R, Wang G, Li M, et al. An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development. Cell 2023, 186: 4454–4471.e19.

CAS  PubMed  Google Scholar 

Hanani M, Spray DC. Emerging importance of satellite glia in nervous system function and dysfunction. Nat Rev Neurosci 2020, 21: 485–498.

CAS  PubMed  PubMed Central  Google Scholar 

Savage VM, Allen AP, Brown JH, Gillooly JF, Herman AB, Woodruff WH, et al. Scaling of number, size, and metabolic rate of cells with body size in mammals. Proc Natl Acad Sci U S A 2007, 104: 4718–4723.

CAS  PubMed  PubMed Central  Google Scholar 

Chen WW, Wu Z, Li H. The microglial lineage: Present and beyond. Trends Immunol 2025, 46: 438–440.

CAS  PubMed  Google Scholar 

Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, et al. Cross-species single-cell analysis reveals divergence of the primate microglia program. Cell 2019, 179: 1609–1622.e16.

CAS  PubMed  Google Scholar 

Chu C, Murdock MH, Jing D, Won TH, Chung H, Kressel AM, et al. The microbiota regulate neuronal function and fear extinction learning. Nature 2019, 574: 543–548.

CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, Wei J, Li L, Shu Z, You L, Liu Y, et al. Microglial Pten safeguards postnatal integrity of the cortex and sociability. Front Immunol 2022, 13: 1059364.

CAS  PubMed  PubMed Central  Google Scholar 

Kimura K, Subramanian A, Yin Z, Khalilnezhad A, Wu Y, He D, et al. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease. Nature 2025, 641: 718–731.

CAS  PubMed  Google Scholar 

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