Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI

Sofroniew MV, Vinters HV. Astrocytes: Biology and pathology. Acta Neuropathol 2010, 119: 7–35.

Article  PubMed  Google Scholar 

Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature 2010, 468: 232–243.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirrlinger J, Nimmerjahn A. A perspective on astrocyte regulation of neural circuit function and animal behavior. Glia 2022, 70: 1554–1580.

Article  PubMed  PubMed Central  Google Scholar 

Verkhratsky A, Nedergaard M. Physiology of astroglia. Physiol Rev 2018, 98: 239–389.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Institoris A, Vandal M, Peringod G, Catalano C, Tran CH, Yu X. Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice. Nat Commun 2022, 13: 7872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takata N, Sugiura Y, Yoshida K, Koizumi M, Hiroshi N, Honda K, et al. Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation. Glia 2018, 66: 2013–2023.

Article  PubMed  Google Scholar 

Christie IN, Wells JA, Southern P, Marina N, Kasparov S, Gourine AV, et al. fMRI response to blue light delivery in the naïve brain: Implications for combined optogenetic fMRI studies. Neuroimage 2013, 66: 634–641.

Article  PubMed  Google Scholar 

Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001, 412: 150–157.

Article  CAS  PubMed  Google Scholar 

Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 1990, 87: 9868–9872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, He Y, Sejnowski TJ, Yu X. Brain-state dependent astrocytic Ca2+ signals are coupled to both positive and negative BOLD-fMRI signals. Proc Natl Acad Sci U S A 2018, 115: E1647–E1656.

CAS  PubMed  PubMed Central  Google Scholar 

Ma Z, Zhang Q, Tu W, Zhang N. Gaining insight into the neural basis of resting-state fMRI signal. Neuroimage 2022, 250: 118960.

Article  PubMed  PubMed Central  Google Scholar 

Howarth C, Mishra A, Hall CN. More than just summed neuronal activity: How multiple cell types shape the BOLD response. Philos Trans R Soc Lond B Biol Sci 2021, 376: 20190630.

Article  PubMed  Google Scholar 

Leong ATL, Gu Y, Chan YS, Zheng H, Dong CM, Chan RW, et al. Optogenetic fMRI interrogation of brain-wide central vestibular pathways. Proc Natl Acad Sci U S A 2019, 116: 10122–10129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grimm C, Frässle S, Steger C, von Ziegler L, Sturman O, Shemesh N, et al. Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia. Cell Rep 2021, 37: 110161.

Article  CAS  PubMed  Google Scholar 

Altahini S, Arnoux I, Stroh A. Optogenetics 2.0: Challenges and solutions towards a quantitative probing of neural circuits. Biol Chem 2023, 405: 43–54.

Article  PubMed  Google Scholar 

Zou Y, Tong C, Peng W, Qiu Y, Li J, Xia Y, et al. Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference. Neuron 2024, 112: 1342-1357.e6.

Article  CAS  PubMed  Google Scholar 

Hamada HT, Abe Y, Takata N, Taira M, Tanaka KF, Doya K. Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation. Nat Commun 2024, 15: 4152.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schulz K, Sydekum E, Krueppel R, Engelbrecht CJ, Schlegel F, Schröter A, et al. Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex. Nat Methods 2012, 9: 597–602.

Article  CAS  PubMed  Google Scholar 

Lohani S, Poplawsky AJ, Kim SG, Moghaddam B. Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI. Mol Psychiatry 2017, 22: 585–594.

Article  CAS  PubMed  Google Scholar 

Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, et al. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 2010, 465: 788–792.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolk SM, Rakic P. Development of prefrontal cortex. Neuropsychopharmacology 2022, 47: 41–57.

Article  CAS  PubMed  Google Scholar 

Reinert S, Hübener M, Bonhoeffer T, Goltstein PM. Mouse prefrontal cortex represents learned rules for categorization. Nature 2021, 593: 411–417.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le Merre P, Ährlund-Richter S, Carlén M. The mouse prefrontal cortex: Unity in diversity. Neuron 2021, 109: 1925–1944.

Article  PubMed  Google Scholar 

Pittolo S, Yokoyama S, Willoughby DD, Taylor CR, Reitman ME, Tse V, et al. Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 2022, 40: 111426.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, et al. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. J Neuroinflammation 2022, 19: 166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Codeluppi SA, Xu M, Bansal Y, Lepack AE, Duric V, Chow M, et al. Prefrontal cortex astroglia modulate anhedonia-like behavior. Mol Psychiatry 2023, 28: 4632–4641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee T, Cai LX, Lelyveld VS, Hai A, Jasanoff A. Molecular-level functional magnetic resonance imaging of dopaminergic signaling. Science 2014, 344: 533–535.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Mo JW, Wang X, An Z, Zhang S, Zhang CY, et al. Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression. Sci Adv 2022, 8: eabo2098.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vo TT, Im GH, Han K, Suh M, Drew PJ, Kim SG. Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation. Proc Natl Acad Sci U S A 2023, 120: e2220777120.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Sobczak F, Pais-Roldán P, Schwarz C, Koretsky AP, Yu X. Mapping the brain-wide network effects by optogenetic activation of the corpus callosum. Cereb Cortex 2020, 30: 5885–5898.

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif