Liu Q, Bhuiyan MIH, Liu R, Song S, Begum G, Young CB. Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. J Neuroinflammation 2021, 18: 187.

CAS  PubMed  PubMed Central  Google Scholar 

He Y, Li Z, Shi X, Ding J, Wang X. Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion. J Cereb Blood Flow Metab 2023, 43: 78–94.

CAS  PubMed  PubMed Central  Google Scholar 

Zheng L, Jia J, Chen Y, Liu R, Cao R, Duan M, et al. Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance. J Neuroinflammation 2022, 19: 128.

CAS  PubMed  PubMed Central  Google Scholar 

Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, et al. New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination. Nat Neurosci 2022, 25: 415–420.

CAS  PubMed  PubMed Central  Google Scholar 

Ma XR, Zhu X, Xiao Y, Gu HM, Zheng SS, Li L, et al. Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nat Commun 2022, 13: 1225.

CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Liu Y, Guo Z, Cui M, Pang P, Yang J, et al. Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats. Acta Pharm Sin B 2023, 13: 2107–2123.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Shu X, Cao Q, Xu L, Wang Z, Li C, et al. Compound from Magnolia officinalis ameliorates white matter injury by promoting oligodendrocyte maturation in chronic cerebral ischemia models. Neurosci Bull 2023, 39: 1497–1511.

CAS  PubMed  PubMed Central  Google Scholar 

Warnock A, Toomey LM, Wright AJ, Fisher K, Won Y, Anyaegbu C, et al. Damage mechanisms to oligodendrocytes and white matter in central nervous system injury: The Australian context. J Neurotrauma 2020, 37: 739–769.

PubMed  Google Scholar 

Poitelon Y, Kopec AM, Belin S. Myelin fat facts: An overview of lipids and fatty acid metabolism. Cells 2020, 9: 812.

CAS  PubMed  PubMed Central  Google Scholar 

Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, et al. Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep 2021, 37: 109898.

CAS  PubMed  PubMed Central  Google Scholar 

Deoni S, Dean D 3rd, Joelson S, O’Regan J, Schneider N. Early nutrition influences developmental myelination and cognition in infants and young children. Neuroimage 2018, 178: 649–659.

PubMed  Google Scholar 

Langley MR, Triplet EM, Scarisbrick IA. Dietary influence on central nervous system myelin production, injury, and regeneration. Biochim Biophys Acta Mol Basis Dis 2020, 1866: 165779.

CAS  PubMed  Google Scholar 

Dimas P, Montani L, Pereira JA, Moreno D, Trötzmüller M, Gerber J, et al. CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes. Elife 2019, 8: e44702.

CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Pu H, Hu X, Wei Z, Hong D, Zhang W, et al. A post-stroke therapeutic regimen with omega-3 polyunsaturated fatty acids that promotes white matter integrity and beneficial microglial responses after cerebral ischemia. Transl Stroke Res 2016, 7: 548–561.

CAS  PubMed  PubMed Central  Google Scholar 

Senthil Kumar JB, Sharma B. A review on neuropharmacological role of erucic acid: An omega-9 fatty acid from edible oils. Nutr Neurosci 2022, 25: 1041–1055.

Google Scholar 

Tamilmani E, Radhakrishnan R, Sankaran K. 13-Docosenamide release by bacteria in response to glucose during growth-fluorescein quenching and clinical application. Appl Microbiol Biotechnol 2018, 102: 6673–6685.

CAS  PubMed  Google Scholar 

Vedpal JS, Jubie S, Deepika NP, Dhanabal SP. A new pyrimidine alkaloid from the roots of Tadehagi triquetrum (L.) H. Ohashi. Nat Prod Res 2021, 35: 413–420.

CAS  PubMed  Google Scholar 

Kim CR, Kim HS, Choi SJ, Kim JK, Gim MC, Kim YJ, et al. Erucamide from radish leaves has an inhibitory effect against acetylcholinesterase and prevents memory deficit induced by trimethyltin. J Med Food 2018, 21: 769–776.

CAS  PubMed  Google Scholar 

Ferdous A, Janta RA, Arpa RN, Afroze M, Khan M, Moniruzzaman M. The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. J Ethnopharmacol 2020, 261: 113148.

CAS  PubMed  Google Scholar 

Li MM, Jiang ZE, Song LY, Quan ZS, Yu HL. Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus-pituitary-adrenal axis in mice. Neurosci Lett 2017, 640: 6–12.

CAS  PubMed  Google Scholar 

Deng S, Shu S, Zhai L, Xia S, Cao X, Li H, et al. Optogenetic stimulation of mPFC alleviates white matter injury-related cognitive decline after chronic ischemia through adaptive myelination. Adv Sci (Weinh) 2023, 10: e2202976.

PubMed  Google Scholar 

Cao Q, Chen J, Zhang Z, Shu S, Qian Y, Yang L, et al. Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia. J Neuroinflammation 2023, 20: 105.

CAS  PubMed  PubMed Central  Google Scholar 

Ye L, Shu S, Jia J, Sun M, Xu S, Bao X, et al. Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis. Aging Cell 2023, 22: e13860.

CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Du X, Yang Q, Li M, Ran Q, Liu Q, et al. Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair. Phytomedicine 2022, 106: 154309.

CAS  PubMed  Google Scholar 

Ilyasov AA, Milligan CE, Pharr EP, Howlett AC. The endocannabinoid system and oligodendrocytes in health and disease. Front Neurosci 2018, 12: 733.

PubMed  PubMed Central  Google Scholar 

Jeffries MA, McLane LE, Khandker L, Mather ML, Evangelou AV, Kantak D, et al. mTOR signaling regulates metabolic function in oligodendrocyte precursor cells and promotes efficient brain remyelination in the cuprizone model. J Neurosci 2021, 41: 8321–8337.

CAS  PubMed  PubMed Central  Google Scholar 

Sánchez-de la Torre A, Aguado T, Huerga-Gómez A, Santamaría S, Gentile A, Chara JC, et al. Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice. Cell Death Dis 2022, 13: 585.

PubMed  PubMed Central  Google Scholar 

Gomez O, Sanchez-Rodriguez A, Le M, Sanchez-Caro C, Molina-Holgado F, Molina-Holgado E. Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways. Br J Pharmacol 2011, 163: 1520–1532.

CAS  PubMed  PubMed Central  Google Scholar 

Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman MH. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol 2021, 45: 102047.

CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Nguyen NH, Magtoto CM, Cobbold SA, Bidgood GM, Meza Guzman LG, et al. Design and characterization of a heterobifunctional degrader of KEAP1. Redox Biol 2023, 59: 102552.

CAS  PubMed  Google Scholar 

Hamberger A, Stenhagen G. Erucamide as a modulator of water balance: New function of a fatty acid amide. Neurochem Res 2003, 28: 177–185.

CAS  PubMed  Google Scholar 

Zhang LY, Pan J, Mamtilahun M, Zhu Y, Wang L, Venkatesh A, et al. Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. Theranostics 2020, 10: 74–90.

PubMed  PubMed Central  Google Scholar 

Qin C, Fan WH, Liu Q, Shang K, Murugan M, Wu LJ, et al. Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway. Stroke 2017, 48: 3336–3346.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Ya D, Yang J, Jiang Y, Li X, Wang J, et al. EAAT3 impedes oligodendrocyte remyelination in chronic cerebral hypoperfusion-induced white matter injury. CNS Neurosci Ther 2024, 30: e14487.

CAS  PubMed  Google Scholar 

Miyamoto N, Magami S, Inaba T, Ueno Y, Hira K, Kijima C, et al. The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter