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Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia
Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia
Diagnosis of Frontotemporal dementia (FTD) and its specific underlying neuropathologies (frontotemporal lobar degeneration...
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity
To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceo...
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
The autophagy-lysosomal pathway is crucial for maintaining homeostasis and survival of neurons, hence defects in this syst...
APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype
APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype
Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing an...
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s di...
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxi...
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression...
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic G...
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue ...
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Parkinson’s disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the pro...
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption o...
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated wi...
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neu...
Alzheimer’s genes in microglia: a risk worth investigating
Alzheimer’s genes in microglia: a risk worth investigating
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is s...
Donald Lowell Price, M.D. In memoriam
Donald Lowell Price, M.D. In memoriam
Molecu...
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal ...
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the ...
Altered plasma protein profiles in genetic FTD – a GENFI study
Altered plasma protein profiles in genetic FTD – a GENFI study
Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to...
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-pro...
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highli...
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD)....
α-Synuclein serine129 phosphorylation – the physiology of pathology
α-Synuclein serine129 phosphorylation – the physiology of pathology
The study that found phospho-serine129 in the Parkinson’s-linked protein alpha-synuclein over two decades ago proposed a p...
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper an...
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, et al. Cerebral Hemorrhage after passive anti-a...
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also ob...
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, et al. Preclinical and randomized clinical evaluation of ...
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs cont...
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
With the emergence of microglia-modulating therapies there is an urgent need for reliable biomarkers to evaluate microglia...
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