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Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)
Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)
Parkinson’s disease with dementia (PDD) is a neurological disorder that clinically and neuropathologically overlaps ...
Assessment of Hippocampal-Related Behavioral Changes in Adolescent Rats of both Sexes Following Voluntary Intermittent Ethanol Intake and Noise Exposure: A Putative Underlying Mechanism and Implementation of a Non-pharmacological Preventive Strategy
Assessment of Hippocampal-Related Behavioral Changes in Adolescent Rats of both Sexes Following Voluntary Intermittent Ethanol Intake and Noise Exposure: A Putative Underlying Mechanism and Implementation of a Non-pharmacological Preventive Strategy
Ethanol (EtOH) intake and noise exposure are particularly concerning among human adolescents because the potential to harm...
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice
Central nervous system oxygen toxicity (CNS-OT) is a complication of hyperbaric oxygen (HBO) treatment, with limited preve...
FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription
FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription
Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in pathological conditions including ...
The Role of Excitotoxicity, Oxidative Stress and Bioenergetics Disruption in the Neuropathology of Nonketotic Hyperglycinemia
The Role of Excitotoxicity, Oxidative Stress and Bioenergetics Disruption in the Neuropathology of Nonketotic Hyperglycinemia
Nonketotic hyperglycinemia (NKH) is an inherited disorder of amino acid metabolism biochemically characterized by the accu...
Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its pr...
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal apoptosis via mitochondrial autophagy in ...
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Amyloid-peptide (Aβ) monomeric forms (ABM) occurring in presymptomatic Alzheimer’s disease (AD) brain are thoug...
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Melatonin (MTN) is a neuro-hormone released from the pineal gland. MTN secretion is regulated by different neuronal circui...
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
There is a public health concern about the use of methylphenidate (MPH) since the higher prescription for young individual...
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
Monosodium glutamate (MSG) is a silent excitotoxin used as a flavour enhancer but exerts serious health hazards to consume...
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Recently a novel genetically modified mouse strain with serum carboxylesterase knocked-out and the human acetylcholinester...
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central...
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
Excitotoxicity linked either to environmental causes (pesticide and cyanotoxin exposure), excitatory neurotransmitter imba...
No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage
No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a stroke subtype with a high mortality rate (~ 40%). After ICH, the mass effect of...
Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice
Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice
Chronic use of typical antipsychotics can lead to varying motor effects depending on the timing of analysis. Acute treatme...
(m) RVD-hemopressin (α) Ameliorated Oxidative Stress, Apoptosis and Damage to the BDNF/TrkB/Akt Pathway Induced by Scopolamine in HT22 Cells
(m) RVD-hemopressin (α) Ameliorated Oxidative Stress, Apoptosis and Damage to the BDNF/TrkB/Akt Pathway Induced by Scopolamine in HT22 Cells
Dysfunction in the cholinergic system and oxidative stress are closely related and play roles in Alzheimer's disease (...
Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
Novel approaches are required to find new treatments for schizophrenia and other neuropsychiatric disorders. This study ut...
Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System
Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System
Addiction is a serious public health problem, and the current pharmacotherapy is unable to prevent drug use reinstatement....
Letter to the Neurotoxicity Research Community
Letter to the Neurotoxicity Research Community
Over 24 years have gone since Neurotoxicity Research was first published in March 1999. During this entire time, the journ...
Biological Pathways Associated with Vitamins in Autism Spectrum Disorder
Biological Pathways Associated with Vitamins in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is characterized by early-appearing social communication deficits, with genetic and environ...
BIN1 in the Pursuit of Ousting the Alzheimer’s Reign: Impact on Amyloid and Tau Neuropathology
BIN1 in the Pursuit of Ousting the Alzheimer’s Reign: Impact on Amyloid and Tau Neuropathology
Alzheimer’s disease contributes to 60–70% of all dementia cases in the general population. Belonging to the BI...
Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats
Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats
Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by behavioral, cognitive, and...
Effect of Cannabidiol in LPS-Induced Toxicity in Astrocytes: Possible Role for Cannabinoid Type-1 Receptors
Effect of Cannabidiol in LPS-Induced Toxicity in Astrocytes: Possible Role for Cannabinoid Type-1 Receptors
Cerebral metabolic abnormalities are common in neurodegenerative diseases. Previous studies have shown that mitochondrial ...
RNA-Binding Proteins: A Role in Neurotoxicity?
RNA-Binding Proteins: A Role in Neurotoxicity?
Despite sustained efforts to treat neurodegenerative diseases, little is known at the molecular level to understand and ge...
Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model
Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model
Several studies have identified the effects of methamphetamine (MA) on central dopaminergic neurons, but its effects on en...
Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Patients with Alzheimer's disease have increased risk of developing heart disease, which therefore highlights the need...
Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex
Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex
Glutamate in monosodium glutamate (MSG), which is widely used in the food industry, has an important role in major brain f...
Correction to: D‑Ribose‑L‑Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase‑3 and GFAP Expressions Following Manganese‑Induced Neurotoxicity
Correction to: D‑Ribose‑L‑Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase‑3 and GFAP Expressions Following Manganese‑Induced Neurotoxicity
Cite this articleAkingbade, G.T., Ijomone, O.M., Imam, A. et al. Correction to: D‑Ribose‑L‑Cysteine Improves Glutathione L...
Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice
Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice
Heart failure (HF) is a major health burden worldwide, with approximately half of HF patients having a comorbid cognitive ...
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