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A Narrative Review on the Role of Microbiota and Microglia in Premotor Symptoms of Parkinson’s Disease
A Narrative Review on the Role of Microbiota and Microglia in Premotor Symptoms of Parkinson’s Disease
With the advent of medical technology and the sustenance of a longer lifespan, an increase in the number of age-related ne...
Novel Evidence of Bisphenol A as a Neuroinflammatory Modulator through the cGAS-STING-NLRP3 Pathway
Novel Evidence of Bisphenol A as a Neuroinflammatory Modulator through the cGAS-STING-NLRP3 Pathway
Bisphenol A (BPA), a widely prevalent environmental contaminant, has been linked to neuroinflammation; however, the molecu...
Neuroprotective Roles of Metformin in a Streptozotocin-Induced Dementia Model in Rats
Neuroprotective Roles of Metformin in a Streptozotocin-Induced Dementia Model in Rats
Alzheimer’s disease (AD) is the leading cause of dementia in humans, with high social and economic costs. AD is pred...
A Balanced Cannabinoids Mixture Protects Neural Stem/progenitor Cells from CoCl2 Induced Injury by Regulating Autophagy and Inflammation: An in Vitro Study
A Balanced Cannabinoids Mixture Protects Neural Stem/progenitor Cells from CoCl2 Induced Injury by Regulating Autophagy and Inflammation: An in Vitro Study
Although tetrahydrocannabinol (THC) and cannabidiol (CBD) have been individually studied for their neuroprotective roles, ...
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease
Tetracycline-derived compounds with anti-inflammatory properties have demonstrated neuroprotective potential in preclinica...
Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis
Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease causing motor neuron loss. 90–95% of ...
Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review
Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review
Oxaliplatin-induced peripheral neuropathy (OIPN) is a severe, dose-limiting complication that significantly reduces qualit...
Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation
Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation
Melamine, an industrial chemical linked to neurotoxicity, prompted this study investigating taurine’s neuroprotectiv...
Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis
Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis
We previously identified a set of genes with hypermethylated promoter regions that expressed reduced levels of mRNAs by ne...
The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity
The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity
The objective of the present review is to discuss the involvement of altered mitochondrial quality control in Mn-induced n...
Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors
Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, charac...
Protective Effect of Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model
Protective Effect of Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model
Background and Objectives: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neuro...
Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization
Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization
Background: Observational studies have shown that exposure to per- and polyfluoroalkyl substances can lead to neurotoxicit...
IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression
IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression
Cerebral ischemia-reperfusion (I/R) injury is the main cause of early complications and adverse outcomes after treatment s...
Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats
Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats
Atomoxetine (ATX) and methylphenidate (MPH) are routinely prescribed for the treatment of attention-deficit/hyperactivity ...
Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review
Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review
Arsenic is a prevalent and significant cause of poisoning worldwide, leading to both acute and chronic toxicity. The life-...
Niacin Protects iPSC-Derived Neurons from Chemotherapy-Induced Toxicity
Niacin Protects iPSC-Derived Neurons from Chemotherapy-Induced Toxicity
Neurotoxicity remains a major dose-limiting adverse effect of cancer therapy. Previous studies have indicated that niacin ...
Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review
Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, and repetitive and ag...
Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin
Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin
Excitotoxic signaling mediated by N-methyl-D-aspartate receptors (NMDARs) is inhibited by NMDAR/TRPM4 complex inhibitors s...
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Trimethyltin chloride (TMT) is a neurotoxicant that damages the central nervous system (CNS) and triggers neurodegeneratio...
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms
The antidiabetic drug metformin possesses antioxidant and cell protective effects including in neuronal cells, suggesting ...
Protective Effect of -Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish
Protective Effect of -Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish
Neural tube defects (NTDs) are severe congenital anomalies affecting 1–2 infants per 1000 births, and are influenced...
Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage
Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage
This study aimed to investigate the neuroprotective potential of the tetracycline (TC) antibiotic oxytetracycline (OT) and...
Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking
Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking
Commercial decabromodiphenyl ether (c-decaBDE) is a widely used additive flame retardant in textiles and plastics. This fo...
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Epilepsy is a chronic noncommunicable neurological disorder characterized by recurrent seizures and ranks as the seventh m...
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HA...
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Recent studies have identified the angiotensin-converting enzyme (ACE) gene as a potential candidate influencing Alzheimer...
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
Methamphetamine (METH) abuse and HIV infection are major public health concerns worldwide. While both METH and HIV- 1 Tat ...
Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
Increasing evidence of ocular impairments in Alzheimer’s disease (AD) has drawn the attention of researchers worldwi...
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with HO
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with HO
This study investigates the potential protective role of annexin A1 (ANXA1) in cell models of H2O2-induced Alzheimer’...
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