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TAS2R38 taster variants-linked MGAM expression in Alzheimer’s disease: a novel target for precision drug repurposing
TAS2R38 taster variants-linked MGAM expression in Alzheimer’s disease: a novel target for precision drug repurposing
IntroductionTAS2R38 is a taste receptor gene located on human chromosome 7 that influences sensitivity to bitter tastes an...
Physiotherapy case reports on three people with progressive supranuclear palsy
Physiotherapy case reports on three people with progressive supranuclear palsy
IntroductionProgressive supranuclear palsy (PSP) is a neurodegenerative brain disease that affects patient’s functionality...
Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
We examined the relationship between hippocampal subfield volumes and cognitive decline over a 4-year period in a healthy ...
Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging
Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging
IntroductionAging is a physiological process occurring in all living organisms. It is characterized by a progressive deter...
A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer’s disease mouse models through attenuating mitochondrial function
A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer’s disease mouse models through attenuating mitochondrial function
IntroductionAlzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by extracellular senile...
Causal associations between common musculoskeletal disorders and dementia: a Mendelian randomization study
Causal associations between common musculoskeletal disorders and dementia: a Mendelian randomization study
IntroductionDementia and musculoskeletal disorders (MSDs) are major public health problems. We aimed to investigate the ge...
Altered dynamic functional network connectivity in drug-naïve Parkinson’s disease patients with excessive daytime sleepiness
Altered dynamic functional network connectivity in drug-naïve Parkinson’s disease patients with excessive daytime sleepiness
BackgroundExcessive daytime sleepiness (EDS) is a frequent nonmotor symptoms of Parkinson’s disease (PD), which seriously ...
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
IntroductionPostoperative delirium (POD) is an acute, transient brain disorder associated with decreased postoperative qua...
Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
BackgroundNeuroimaging studies have demonstrated alterations in hippocampal volume and hippocampal subfields among individ...
Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults
Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults
BackgroundOligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer’s disease (AD) diagnosis. Electroencephalograp...
Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease
Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease
Subjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common ...
Association between gene expression and altered resting-state functional networks in type 2 diabetes
Association between gene expression and altered resting-state functional networks in type 2 diabetes
BackgroundType 2 diabetes (T2DM) is a polygenic metabolic disorder that accelerates brain aging and harms cognitive functi...
Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications
Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications
Cognitive impairments, such as learning and memory deficits, may occur in susceptible populations including the elderly an...
Genome-wide association study in Alzheimer’s disease: a bibliometric and visualization analysis
Genome-wide association study in Alzheimer’s disease: a bibliometric and visualization analysis
BackgroundThousands of research studies concerning genome-wide association studies (GWAS) in Alzheimer’s disease (AD) have...
Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer’s disease
Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is a multifactorial neurodegenerative condition. The search for multi-target traditiona...
Corrigendum: Prefrontal event-related potential markers in association with mild cognitive impairment
Corrigendum: Prefrontal event-related potential markers in association with mild cognitive impairment
Corrigendum on: Eyamu J, Kim W-S, Kim K, Lee KH and Kim JU ( 2023) Prefrontal eventrelated potential markers in associatio...
Associations of sarcopenia, sarcopenia parameters and motoric cognitive risk syndrome in Chinese older adults
Associations of sarcopenia, sarcopenia parameters and motoric cognitive risk syndrome in Chinese older adults
BackgroundMotoric cognitive risk syndrome (MCR) is a pre-dementia symptom strongly predicting cognitive decline and dement...
Larger deep white matter hyperintensity volume correlates with more severe social behavioral changes in patients with subacute ischemic stroke
Larger deep white matter hyperintensity volume correlates with more severe social behavioral changes in patients with subacute ischemic stroke
BackgroundChanges in social behavior can occur after ischemic stroke. We aimed to investigate the potential correlations b...
Impaired night-time mobility in patients with Parkinson’s disease: a systematic review
Impaired night-time mobility in patients with Parkinson’s disease: a systematic review
Impaired bed mobility (IBM) is a symptom characteristic of patients having difficulty intentionally moving their bodies du...
Engineering Virtuous health habits using Emotion and Neurocognition: Flexibility for Lifestyle Optimization and Weight management (EVEN FLOW)
Engineering Virtuous health habits using Emotion and Neurocognition: Flexibility for Lifestyle Optimization and Weight management (EVEN FLOW)
Interventions to preserve functional independence in older adults are critically needed to optimize ‘successful aging’ amo...
Development and preliminary validation of a virtual reality memory test for assessing visuospatial memory
Development and preliminary validation of a virtual reality memory test for assessing visuospatial memory
BackgroundVisuospatial memory impairment is a common symptom of Alzheimer’s disease; however, conventional visuospatial me...
Cellular senescence in brain aging and cognitive decline
Cellular senescence in brain aging and cognitive decline
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases....
Efficacy of smartphone application-based multi-domain cognitive training in older adults without dementia
Efficacy of smartphone application-based multi-domain cognitive training in older adults without dementia
BackgroundAs the population ages and the prevalence of dementia increases, there is a growing emphasis on the importance o...
The impact of cognitive reserve on delayed neurocognitive recovery after major non-cardiac surgery: an exploratory substudy
The impact of cognitive reserve on delayed neurocognitive recovery after major non-cardiac surgery: an exploratory substudy
IntroductionDelayed neurocognitive recovery is a common and severe complication after surgery and anesthesia with an adver...
Editorial: Technologies to support elderly patients with dementia
Editorial: Technologies to support elderly patients with dementia
The purpose of this research topic is to bring together a collection of papers illustrating an exciting scenario on techno...
Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study
Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study
During the last decades, our knowledge about the genetic architecture of sporadic amyotrophic lateral sclerosis (sALS) has...
Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification
Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification
BackgroundNeuromelanin- and iron-sensitive MRI studies in Parkinson's disease (PD) are limited by small sample sizes a...
Associations between microstructural tissue changes, white matter hyperintensity severity, and cognitive impairment: an intravoxel incoherent motion imaging study
Associations between microstructural tissue changes, white matter hyperintensity severity, and cognitive impairment: an intravoxel incoherent motion imaging study
IntroductionWhite matter hyperintensities (WMHs) are a common age- and vascular risk factor-related disease and have been ...
Editorial: Present and future of biological fluid biomarkers in dementia
Editorial: Present and future of biological fluid biomarkers in dementia
Alzheimer's disease (AD) and dementia constitute significant challenges to global healthcare systems, as a result of i...
Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial
Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial
IntroductionAfrican Americans are two to three times more likely to be diagnosed with Alzheimer’s disease (AD) compared to...
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