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Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts
Neuronal replacement therapy recently holds promise for neurodegenerative disease treatment. Somatic cell-derived neurons ...
Ferroptosis: Disease Associations and Therapeutic Target Exploration
Ferroptosis: Disease Associations and Therapeutic Target Exploration
Ferroptosis, a distinct form of cell death, is transforming the understanding of complex diseases such as cancer, neurodeg...
Salicylaldehyde Benzoylhydrazone Protects Against Ferroptosis in Models of Neurotoxicity and Behavioural Dysfunction, In Vitro and In Vivo
Salicylaldehyde Benzoylhydrazone Protects Against Ferroptosis in Models of Neurotoxicity and Behavioural Dysfunction, In Vitro and In Vivo
Metal dyshomeostasis in the brain is a key feature of many neuropathologies, including hypoxic and traumatic injury and ch...
The Astrocyte Elevated Gene- 1 Expression and other Risk Factors for Different Varieties of Diabetic Optic Neuropathy in Egyptian Patients with Diabetic Retinopathy
The Astrocyte Elevated Gene- 1 Expression and other Risk Factors for Different Varieties of Diabetic Optic Neuropathy in Egyptian Patients with Diabetic Retinopathy
To assess the role of the mRNA and protein expression of Astrocyte Elevated Gene- 1 (AEG-1) and other possible risk factor...
Cerebrospinal Fluid-Derived Genomic Alterations Tracking Glioma
Cerebrospinal Fluid-Derived Genomic Alterations Tracking Glioma
Diffuse gliomas are aggressive brain tumors known for heterogeneity and frequent oncogenic mutations. Our study harnessed ...
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
Discovered in 1989, pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with strong neuroprotecti...
The Progress of Cognitive Dysfunction Impairment Caused by Temporal Lobe Epilepsy
The Progress of Cognitive Dysfunction Impairment Caused by Temporal Lobe Epilepsy
Epilepsy is a chronic disease that is characterized primarily by seizures. One of the most common and detrimental comorbid...
3-Phenoxybenzoic Acid Induces Neuronal Pentraxin 2 to Upregulate Complement Activity and Promotes Microglia-Mediated Neuronal Synaptic Damage
3-Phenoxybenzoic Acid Induces Neuronal Pentraxin 2 to Upregulate Complement Activity and Promotes Microglia-Mediated Neuronal Synaptic Damage
3-Phenoxybenzoic acid (3-PBA) has been demonstrated to be associated with neurrotoxicity, however, the precise me...
Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation
Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation
Dysregulated autophagy and copper/zinc superoxide dismutase (SOD1) protein aggregation play a crucial role in amyotrophic ...
Impaired Flow: Glymphatic Dysfunction in Ischemic Stroke and the Influence of Sex
Impaired Flow: Glymphatic Dysfunction in Ischemic Stroke and the Influence of Sex
The glymphatic system, essential for the clearance of metabolic waste from the brain, plays a complex role in the context ...
Vascular Cell Adhesion Molecule-1 and Complement C3 involvement in Febrile Seizures in Children
Vascular Cell Adhesion Molecule-1 and Complement C3 involvement in Febrile Seizures in Children
Elevated inflammation, characterized by increased proinflammatory cytokine levels in febrile seizures (FSs), has been well...
Non-targeted and Targeted Metabolomics Techniques Reveal Striatal Metabolome Characteristics in the Ketamine-Induced Conditioned Place Preference Mice Model
Non-targeted and Targeted Metabolomics Techniques Reveal Striatal Metabolome Characteristics in the Ketamine-Induced Conditioned Place Preference Mice Model
Ketamine is a synthesized anesthetic drug that was used extensively as a surgical anesthetic in the 1960s. Currently, keta...
Decoding EGFR A289 Mutation in Glioblastoma: A Predictive Biomarker Framework and Targeted Therapeutic Insights
Decoding EGFR A289 Mutation in Glioblastoma: A Predictive Biomarker Framework and Targeted Therapeutic Insights
Glioblastoma (GBM) is the most common primary malignant intracranial tumor, accounting for over 50% of central nervous sys...
Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
The rising incidence of brain diseases parallels the global trend of an aging population, with Alzheimer’s disease (...
Multi-tissue Methylation Analysis of Alzheimer’s Disease: Insights into Pathways, Modules, and Key Genes
Multi-tissue Methylation Analysis of Alzheimer’s Disease: Insights into Pathways, Modules, and Key Genes
DNA methylation plays a crucial role in the onset and progression of Alzheimer’s disease (AD). Genome-wide methylati...
Methylomic Changes in MTHFR Promoter Region, along with the Heterozygous C677T Polymorphism, Contribute to the Risk of Thrombotic Stroke
Methylomic Changes in MTHFR Promoter Region, along with the Heterozygous C677T Polymorphism, Contribute to the Risk of Thrombotic Stroke
Stroke is the second leading cause of death globally and a major contributor to disability. Developing countries report th...
ZDHHC13 Reduces the Risk of Ischemic Stroke by Regulating Metabolites
ZDHHC13 Reduces the Risk of Ischemic Stroke by Regulating Metabolites
Recent studies have shown that palmitoylation is involved in ischemic stroke(IS). However, the role of palmitoylation in I...
Sleep Deprivation Induces Ferroptosis and Reduces the Expression of GABAB Receptor in Mice
Sleep Deprivation Induces Ferroptosis and Reduces the Expression of GABAB Receptor in Mice
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical ...
Investigating Oxidative Stress and Impaired DNA Repair Capacity as Diagnostic Biomarkers in Autism Spectrum Disorder
Investigating Oxidative Stress and Impaired DNA Repair Capacity as Diagnostic Biomarkers in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social communication deficits...
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
Sevoflurane causes neural injury by promoting apoptosis and oxidative stress. Reactive oxygen species modulator 1 (ROMO1) ...
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Addressing the intricate challenge of chronic neuropathic pain has significant implications for the physical and psycholog...
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
Hereditary sensory and autonomic neuropathy (HSAN) is a rare genetic disorder that primarily affects the peripheral nervou...
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Mitochondrion is an important organelle present in our cells responsible for meeting energy requirements. All higher organ...
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Hearing loss (HL) is one of the most common health problems worldwide. Autosomal recessive non-syndromic sensorineural hea...
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
Although brain amyloid-β (Aβ) peptide buildup is the main cause of Alzheimer’s disease (AD), mitochondrial...
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
Chromodomain helicase DNA-binding 8 (CHD8) is a gene that poses a high risk for autism spectrum disorder (ASD) and neurolo...
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
With the persistent challenge that epilepsy presents to therapeutic avenues, the study seeks to decipher the effe...
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseas...
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Traumatic brain injury (TBI) is caused by an external mechanical force to the head, resulting in abnormal brain functionin...
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the...
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