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Novel Mutation in Hypokalemic Periodic Paralysis: First Report with Functional Validation
Novel Mutation in Hypokalemic Periodic Paralysis: First Report with Functional Validation
Hypokalemic periodic paralysis (HypoPP) is a muscle disease caused by abnormal ion channels and is characterized by recurr...
Resolving Heterogeneity in the Diagnosis of Alzheimer’s Disease and its Progression Using Multimodal Data
Resolving Heterogeneity in the Diagnosis of Alzheimer’s Disease and its Progression Using Multimodal Data
Alzheimer’s disease (AD) is a complex and diverse illness that makes early detection extremely difficult. Most exist...
PRDX6 as a Ferroptosis-Related Hub Gene in the Entorhinal Cortex of Alzheimer’s Disease: A Multidimensional Bioinformatics and Experimental Validation Study
PRDX6 as a Ferroptosis-Related Hub Gene in the Entorhinal Cortex of Alzheimer’s Disease: A Multidimensional Bioinformatics and Experimental Validation Study
Ferroptosis, an iron-dependent regulated cell death form, is a key pathogenic mechanism in Alzheimer’s disease (AD),...
“Unfolding Parkinson’s Disease Through the Microbiome-Gut-Brain Axis”
“Unfolding Parkinson’s Disease Through the Microbiome-Gut-Brain Axis”
Parkinson’s disease (PD) is a progressive and multifactorial neurodegenerative disorder primarily caused by the loss...
Mitophagy Inhibition Suppresses Seizures in Status Epilepticus Mice by Decreasing Hippocampal NLRC4 Expression
Mitophagy Inhibition Suppresses Seizures in Status Epilepticus Mice by Decreasing Hippocampal NLRC4 Expression
Background: Neuroinflammation and mitophagy play crucial roles in temporal lobe epilepsy (TLE) pathogenesis, which follows...
Subacute Iron Exposure in Rats Induces Behavioral Impairments, Oxidative Stress, and Histopathological Alterations
Subacute Iron Exposure in Rats Induces Behavioral Impairments, Oxidative Stress, and Histopathological Alterations
Iron overload can compromise brain integrity, leading to behavioral, biochemical, and structural disturbances. In this stu...
Expanding the Clinical Spectrum of SCN8A-Related Epileptic Encephalopathy: Additional Auditory Impairment, Atypical MRI Abnormalities and Putative Mitochondrial Involvement
Expanding the Clinical Spectrum of SCN8A-Related Epileptic Encephalopathy: Additional Auditory Impairment, Atypical MRI Abnormalities and Putative Mitochondrial Involvement
High expression of the voltage-gated sodium channel NaV1.6 is essential for regulating neuronal excitability in both the c...
MC-350013 and Corylin Emerge as Promising Neuroprotective Agents through Dual Targeting of xCT and GLT-1
MC-350013 and Corylin Emerge as Promising Neuroprotective Agents through Dual Targeting of xCT and GLT-1
Studies have demonstrated the impact of alterations of glutamate homeostasis, involving particularly, its excitotoxicity e...
The Protective Role of Aquaporin 4 (AQP4) in Temporal Lobe Epilepsy: Yes or No?
The Protective Role of Aquaporin 4 (AQP4) in Temporal Lobe Epilepsy: Yes or No?
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults that resists the conventional anti-seizur...
Autism Spectrum Disorders and Purinergic Signaling: A Systematic Review of Emerging Insights from Preclinical Studies
Autism Spectrum Disorders and Purinergic Signaling: A Systematic Review of Emerging Insights from Preclinical Studies
Autism Spectrum Disorders (ASD), are a group of complex neurodevelopmental conditions characterized by deficits in social ...
Chrysin Ameliorates Valproic Acid Induced Autism Spectrum Behavioral Phenotypes Through Corticohippocampal Histone Deacetylase and Translational Modulation of SHANK3 Expression in Juvenile Rats
Chrysin Ameliorates Valproic Acid Induced Autism Spectrum Behavioral Phenotypes Through Corticohippocampal Histone Deacetylase and Translational Modulation of SHANK3 Expression in Juvenile Rats
Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by repetitive behaviors, social deficits, and comor...
Pro-inflammatory Immune Dysregulation and Genetic Susceptibility in Iraqi Children with Autism: a Tetra-Primer ARMS-PCR Investigation of Interleukin Polymorphisms
Pro-inflammatory Immune Dysregulation and Genetic Susceptibility in Iraqi Children with Autism: a Tetra-Primer ARMS-PCR Investigation of Interleukin Polymorphisms
Autism Spectrum Disorder (ASD) is associated with multiple co-occurring conditions. Research has linked ASD with immune dy...
The Expression Patterns of Reference Genes in the Brains of Male Rats Subjected to CUMS-induced Depressive-like Behavior Strongly Depends on both the Age and the Specific Brain Region
The Expression Patterns of Reference Genes in the Brains of Male Rats Subjected to CUMS-induced Depressive-like Behavior Strongly Depends on both the Age and the Specific Brain Region
The objective of this investigation was to identify the most suitable candidates for RT-qPCR analysis. The study focused o...
Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease
Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease
Altered systemic metabolism contributes to Alzheimer’s disease (AD) pathology, yet the links between specific metabo...
Association of Statin use with Parkinson’s Disease Progression in a Prospective Cohort Study and Multi-omics Analyses
Association of Statin use with Parkinson’s Disease Progression in a Prospective Cohort Study and Multi-omics Analyses
While more than 30% of patients with Parkinson’s disease (PD) are prescribed statins, the impact of statin use on th...
Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups
Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups
There is an urgent need for early and accurate biomarkers of neurodegenerative disorders. Due to the high innervation and ...
Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update
Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update
Klotho is an anti-aging protein with multiple functions in maintaining homeostasis within the central nervous system (CNS)...
Protein Acylation Modifications in Sleep Disorders: Mechanisms and Therapeutic Potential
Protein Acylation Modifications in Sleep Disorders: Mechanisms and Therapeutic Potential
Protein acylation represents a class of metabolism-dependent post-translational modifications that are increasingly recogn...
Cognitive and Motor Dysfunction in STXBP1 R406H Mice
Cognitive and Motor Dysfunction in STXBP1 R406H Mice
The STXBP1 protein critically regulates synaptic vesicle fusion and neurotransmitter release, with its mutations implicate...
Lower Plasma Serotonin is Associated with Higher Amyloid Burden, Hippocampal Atrophy, and Cognitive decline in Alzheimer’s Disease: A 24-Month Longitudinal Study
Lower Plasma Serotonin is Associated with Higher Amyloid Burden, Hippocampal Atrophy, and Cognitive decline in Alzheimer’s Disease: A 24-Month Longitudinal Study
This study investigated longitudinal plasma serotonin dynamics across the Alzheimer’s disease (AD) continuum (cognit...
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts
Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts
Neuronal replacement therapy recently holds promise for neurodegenerative disease treatment. Somatic cell-derived neurons ...
Ferroptosis: Disease Associations and Therapeutic Target Exploration
Ferroptosis: Disease Associations and Therapeutic Target Exploration
Ferroptosis, a distinct form of cell death, is transforming the understanding of complex diseases such as cancer, neurodeg...
Salicylaldehyde Benzoylhydrazone Protects Against Ferroptosis in Models of Neurotoxicity and Behavioural Dysfunction, In Vitro and In Vivo
Salicylaldehyde Benzoylhydrazone Protects Against Ferroptosis in Models of Neurotoxicity and Behavioural Dysfunction, In Vitro and In Vivo
Metal dyshomeostasis in the brain is a key feature of many neuropathologies, including hypoxic and traumatic injury and ch...
The Astrocyte Elevated Gene- 1 Expression and other Risk Factors for Different Varieties of Diabetic Optic Neuropathy in Egyptian Patients with Diabetic Retinopathy
The Astrocyte Elevated Gene- 1 Expression and other Risk Factors for Different Varieties of Diabetic Optic Neuropathy in Egyptian Patients with Diabetic Retinopathy
To assess the role of the mRNA and protein expression of Astrocyte Elevated Gene- 1 (AEG-1) and other possible risk factor...
Cerebrospinal Fluid-Derived Genomic Alterations Tracking Glioma
Cerebrospinal Fluid-Derived Genomic Alterations Tracking Glioma
Diffuse gliomas are aggressive brain tumors known for heterogeneity and frequent oncogenic mutations. Our study harnessed ...
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
Discovered in 1989, pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with strong neuroprotecti...
The Progress of Cognitive Dysfunction Impairment Caused by Temporal Lobe Epilepsy
The Progress of Cognitive Dysfunction Impairment Caused by Temporal Lobe Epilepsy
Epilepsy is a chronic disease that is characterized primarily by seizures. One of the most common and detrimental comorbid...
3-Phenoxybenzoic Acid Induces Neuronal Pentraxin 2 to Upregulate Complement Activity and Promotes Microglia-Mediated Neuronal Synaptic Damage
3-Phenoxybenzoic Acid Induces Neuronal Pentraxin 2 to Upregulate Complement Activity and Promotes Microglia-Mediated Neuronal Synaptic Damage
3-Phenoxybenzoic acid (3-PBA) has been demonstrated to be associated with neurrotoxicity, however, the precise me...
Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation
Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation
Dysregulated autophagy and copper/zinc superoxide dismutase (SOD1) protein aggregation play a crucial role in amyotrophic ...
Impaired Flow: Glymphatic Dysfunction in Ischemic Stroke and the Influence of Sex
Impaired Flow: Glymphatic Dysfunction in Ischemic Stroke and the Influence of Sex
The glymphatic system, essential for the clearance of metabolic waste from the brain, plays a complex role in the context ...
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