Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, Bush AI (2020) Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry 25(11):2932–2941. https://doi.org/10.1038/s41380-019-0375-7
Article CAS PubMed Google Scholar
Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Kang SG (2019) Computational aided mechanistic understanding of Camellia sinensis bioactive compounds against co-chaperone p23 as potential anticancer agent. J Cell Biochem 120(11):19064–19075. https://doi.org/10.1002/jcb.29229
Article CAS PubMed Google Scholar
Brigelius-Flohé R (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radical Biol Med 27(9–10):951–965. https://doi.org/10.1016/s0891-5849(99)00173-2
Bucher JR, Tien M, Aust SD (1983) The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron. Biochem Biophys Res Commun 111(3):777–784. https://doi.org/10.1016/0006-291x(83)91366-9
Article CAS PubMed Google Scholar
Cao Y, Li Y, He C, Yan F, Li JR, Xu HZ, Zhuang JF, Zhou H, Peng YC, Fu XJ, Lu XY, Yao Y, Wei YY, Tong Y, Zhou YF, Wang L (2021) Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage. Neurosci Bull 37:535–549. https://doi.org/10.1007/s12264-020-00620-5
Article CAS PubMed PubMed Central Google Scholar
Chen J, Li X, Ge C, Min J, Wang F (2022) The multifaceted role of ferroptosis in liver disease. Cell Death Differ 29(3):467–480. https://doi.org/10.1038/s41418-022-00941-0
Article CAS PubMed PubMed Central Google Scholar
Chen M, Shi Z, Sun Y, Ning H, Gu X, Zhang L (2023) Prospects for anti-tumor mechanism and potential clinical application based on glutathione peroxidase 4 mediated ferroptosis. Int J Mol Sci 24(2):1607. https://doi.org/10.3390/ijms24021607
Article CAS PubMed PubMed Central Google Scholar
Chen T, Ding L, Zhao M, Song S, Hou J, Li X, Li M, Yin K, Li X, Wang Z (2024) Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis. Chinese Medicine 19(1):49. https://doi.org/10.1186/s13020-024-00918-w
Article PubMed PubMed Central Google Scholar
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z (2021) Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis. Biochim Biophys Acta (BBA)-Mol Basis Dis 1867(12):166204. https://doi.org/10.1016/j.bbadis.2021.166204
Comhair SA, Erzurum SC (2010) Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 12(1):93–124. https://doi.org/10.1089/ars.2008.2425
Article CAS PubMed PubMed Central Google Scholar
Conrad M, Angeli JPF, Vandenabeele P, Stockwell BR (2016) Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discovery 15(5):348–366. https://doi.org/10.1038/nrd.2015.6
Article CAS PubMed Google Scholar
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042
Article CAS PubMed PubMed Central Google Scholar
Du Y, Guo Z (2022) Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discovery 8(1):501. https://doi.org/10.1038/s41420-022-01297-7
Article CAS PubMed PubMed Central Google Scholar
Fan J, Jiang T, He D (2023) Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases. Front Immunol 14:1120519. https://doi.org/10.3389/fimmu.2023.1120519
Article CAS PubMed PubMed Central Google Scholar
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O’Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180–1191. https://doi.org/10.1038/ncb3064
Article CAS PubMed Google Scholar
Gan S, Lin L, Chen Z, Zhang H, Tang H, Yang C, Li J, Li S, Yao L (2024) Ferroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model. Exp Cell Res 438(1):114029. https://doi.org/10.1016/j.yexcr.2024.114029
Article CAS PubMed Google Scholar
Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X (2016) Ferroptosis is an autophagic cell death process. Cell Res 26(9):1021–1032. https://doi.org/10.1038/cr.2016.95
Article CAS PubMed PubMed Central Google Scholar
Gao R, Kalathur RKR, Coto-Llerena M, Ercan C, Buechel D, Shuang S, Piscuoglio S, Dill MT, Camargo FD, Christofori G, Tang F (2021) YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis. EMBO molecular medicine 13(12):e14351. https://doi.org/10.15252/emmm.202114351
Article CAS PubMed PubMed Central Google Scholar
Guo L, Hu C, Yao M, Han G (2023) Mechanism of sorafenib resistance associated with ferroptosis in HCC. Front Pharmacol 14:1207496. https://doi.org/10.3389/fphar.2023.1207496
Article CAS PubMed PubMed Central Google Scholar
Guo D, Cai S, Deng L, Xu W, Fu S, Lin Y, Jiang T, Li Q, Shen Z, Zhang JJM (2025) Ferroptosis in pulmonary disease and lung cancer: molecular mechanisms, crosstalk regulation, and therapeutic strategies. MedComm 6(3):e70116. https://doi.org/10.1002/mco2.70116
Article CAS PubMed PubMed Central Google Scholar
Hassannia B, Vandenabeele P, Vanden Berghe T (2019) Targeting ferroptosis to iron out cancer. Cancer Cell 35(6):830–849. https://doi.org/10.1016/j.ccell.2019.04.002
Article CAS PubMed Google Scholar
He S, Sharpless NE (2017) Senescence in health and disease. Cell 69(6):1000–1011. https://doi.org/10.1016/j.cell.2017.05.015
Hirschhorn T, Stockwell BR (2019) The development of the concept of ferroptosis. Free Radical Biol Med 133:130–143. https://doi.org/10.1016/j.freeradbiomed.2018.09.043
Homma T, Kobayashi S, Conrad M, Konno H, Yokoyama C, Fujii J (2021) Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide 115:34–43. https://doi.org/10.1016/j.niox.2021.07.003
Article CAS PubMed Google Scholar
Huang C, Freter C (2015) Lipid metabolism, apoptosis and cancer therapy. Int J Mol Sci 16(1):924–949. https://doi.org/10.3390/ijms16010924
Article CAS PubMed PubMed Central Google Scholar
Huang LL, Liao XH, Sun H, Jiang X, Liu Q, Zhang L (2019) Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis. J Cell Mol Med 23(6):4153–4164. https://doi.org/10.1111/jcmm.14302
Article CAS PubMed PubMed Central Google Scholar
Imai H, Nakagawa Y (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radical Biol Med 34(2):145–169.
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