Drp1-Mediated Mitochondrial Fission Is Essential for Chemical-Induced Neuronal Transdifferentiation from Human Primary Fibroblasts

Agnello L, Ciaccio M (2022) Neurodegenerative diseases: from molecular basis to therapy. Int J Mol Sci 23(21):12854

Article  PubMed  PubMed Central  Google Scholar 

Bertholet AM, Delerue T, Millet AM et al (2016) Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity. Neurobiol Dis 90:3–19

Article  CAS  PubMed  Google Scholar 

Borcherding N, Brestoff JR (2023) The power and potential of mitochondria transfer. Nature 623(7986):283–291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castilho RF, Hansson O, Ward MW, Budd SL, Nicholls DG (1998) Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurosci 18(24):10277–10286

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Chan DC (2009) Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases. Hum Mol Genet 18(R2):R169-176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colasante G, Lignani G, Rubio A et al (2015) Rapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming. Cell Stem Cell 17(6):719–734

Article  CAS  PubMed  Google Scholar 

Eura Y, Ishihara N, Yokota S, Mihara K (2003) Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J Biochem 134(3):333–344

Article  CAS  PubMed  Google Scholar 

Fire A, Xu S, Montgomery MK et al (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391(6669):806–811

Article  CAS  PubMed  Google Scholar 

Gao Q, Tian R, Han H et al (2022) PINK1-mediated Drp 1(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission. Signal Transduct Target Ther 7(1):103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghani M, Zohar P, Ujlaki G et al (2024) Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced phosphorylation of ERK1/2 independently of DUSP1 and 6. Front Cell Dev Biol 12:1342741

Article  PubMed  PubMed Central  Google Scholar 

Grunweller A, Hartmann RK (2005) RNA interference as a gene-specific approach for molecular medicine. Curr Med Chem 12(26):3143–3161

Article  CAS  PubMed  Google Scholar 

Haileselassie B, Joshi AU, Minhas PS et al (2020) Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy. J Neuroinflammation 17(1):36

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoque A, Sivakumaran P, Bond ST et al (2018) Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells. Cell Death Discov 4:39

Article  PubMed  PubMed Central  Google Scholar 

Ishihara N, Nomura M, Jofuku A et al (2009) Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 11(8):958–966

Article  CAS  PubMed  Google Scholar 

Kageyama Y, Zhang Z, Roda R et al (2012) Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol 197(4):535–551

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM (1999) C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 4(5):815–826

Article  CAS  PubMed  Google Scholar 

Li H, Chen Y, Jones AF et al (2008) Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci U S A 105(6):2169–2174

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Zuo X, Jing J et al (2015) Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell 17(2):195–203

Article  CAS  PubMed  Google Scholar 

Li Z, Okamoto K, Hayashi Y, Sheng M (2004) The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119(6):873–887

Article  CAS  PubMed  Google Scholar 

Liu Y, Wang J, Sudhof TC, Wernig M (2023) Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression. Nat Protoc 18(10):2954–2974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandal S, Lindgren AG, Srivastava AS, Clark AT, Banerjee U (2011) Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells 29(3):486–495

Article  CAS  PubMed  Google Scholar 

McComish SF, Caldwell MA (2018) Generation of defined neural populations from pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci 373(1750):20170214

Article  PubMed  PubMed Central  Google Scholar 

Olichon A, Emorine LJ, Descoins E et al (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1–3):171–176

Article  CAS  PubMed  Google Scholar 

Prieto J, Leon M, Ponsoda X et al (2016a) Dysfunctional mitochondrial fission impairs cell reprogramming. Cell Cycle 15(23):3240–3250

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prieto J, Leon M, Ponsoda X et al (2016b) Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun 7:11124

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi Z, Huang Z, Xie F, Chen L (2019) Dynamin-related protein 1: a critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. J Cell Physiol 234(7):10032–10046

Article  CAS  PubMed  Google Scholar 

Quintana-Cabrera R, Scorrano L (2023) Determinants and outcomes of mitochondrial dynamics. Mol Cell 83(6):857–876

Article  CAS  PubMed  Google Scholar 

Rastogi A, Joshi P, Contreras E, Gama V (2019) Remodeling of mitochondrial morphology and function: an emerging hallmark of cellular reprogramming. Cell Stress 3(6):181–194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxton WM, Hollenbeck PJ (2012) The axonal transport of mitochondria. J Cell Sci 125(Pt 9):2095–2104

CAS  PubMed  PubMed Central  Google Scholar 

Sesaki H, Adachi Y, Kageyama Y, Itoh K, Iijima M (2014) In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta 1842(8):1179–1185

Article  CAS  PubMed 

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