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Platelets from early-stage Alzheimer patients show enhanced amyloid binding, an elevated open canalicular system and sex-specific differences in their activation profile
Platelets from early-stage Alzheimer patients show enhanced amyloid binding, an elevated open canalicular system and sex-specific differences in their activation profile
IntroductionAlzheimer's disease (AD) is associated with neurodegeneration and dementia. Key clinical hallmarksinclude the ...
Gut microbiota 16S rRNA profiling with plasma and urine metabolomics in vestibular migraine
BackgroundVestibular migraine (VM) pathophysiology remains unclear, with research often extrapolating from migraine (M) st...
Hidden diagnoses among patients with double seronegative myasthenia gravis
IntroductionDouble seronegative myasthenia gravis (dSnMG) is defined as myasthenia gravis (MG) without detectable antibodi...
Smartphone-based digital phenotyping for characterizing post-operative recovery in patients undergoing surgery for cervical myelopathy
ObjectiveThis study aimed at investigating the feasibility of using personal smartphones to characterize mobility in patie...
Mapping the cognitive landscape: a pilot study of domain-specific outcomes following frontal lobe resection in children with epilepsy
BackgroundPediatric frontal lobe epilepsy surgery can achieve seizure freedom, but cognitive outcomes are heterogeneous an...
Theta-band EEG functional connectivity during emotional music in disorders of consciousness: wPLI differences between MCS and UWS
BackgroundWith the increasing number of patients with disorders of consciousness (DOC), accurate diagnosis—particularly di...
Exploration of spontaneous brain activity abnormalities in high myopia patients using resting-state fMRI with multiparameter analysis
BackgroundHigh myopia (HM) is a common eye disorder which has become a public health problem globally. Previous neuroimagi...
Clinician and patient perspectives on meaningful Parkinson's disease impacts for digital assessment
BackgroundNovel clinical outcome measures that accurately track Parkinson's disease (PD) progression are required to enhan...
Multimodal MRI reveals structural and functional alterations in thyroid-associated ophthalmopathy
ObjectiveThis study aimed to investigate white matter microstructural damage, spontaneous brain activity, and functional c...
Working memory characteristics in T2DM individuals with MMSE-defined cognitive status: a behavioral study
BackgroundCognitive decline is frequently reported in individuals with type 2 diabetes mellitus (T2DM), and working memory...
Glossography – a computer vision technique for assessing involuntary tongue movements in dyskinesias
We present a novel computer vision approach using DeepLabCut to objectively quantify orofacial dyskinesias in Parkinson’s ...
Novel elbow-forearm support orthosis for post-stroke glenohumeral subluxation: a randomized controlled trial protocol
BackgroundGlenohumeral subluxation (GHS) is a common complication following stroke, with an incidence rate of up to 73% in...
Resting-state fMRI dynamic functional network in young children with Tourette syndrome
IntroductionTourette syndrome (TS) is a neurodevelopmental disorder characterized by involuntary motor and phonic tics, wi...
Transspinal direct current stimulation as targeted therapy to increase motor neuron output and restore inhibition in human spinal cord injury
IntroductionIn this clinical trial, we evaluated changes in the output of motoneurons and spinal inhibitory mechanisms acr...
Elevated fibroblast growth factor 23 levels predict cardiovascular and cerebrovascular events in acute ischaemic stroke patients
BackgroundRecent studies on fibroblast growth factor 23 (FGF23) and acute ischaemic stroke (AIS) have been conducted, but ...
Advancing neuro-ophthalmic diagnostics: a multimodal imaging approach integrating OCT angiography and AI-enhanced MRI for improved visual pathway analysis
IntroductionRecent advancements in neuro-ophthalmology necessitate integrative imaging methodologies to address the struct...
Association of benign paroxysmal positional vertigo with meteorological factors in outpatient: a retrospective analysis
BackgroundWhile previous studies have reported associations between benign paroxysmal positional vertigo (BPPV) and meteor...
Association of motoric cognitive risk syndrome and incident mild cognitive impairment in community-dwelling older adults
BackgroundMotoric cognitive risk syndrome (MCR) has been recognized as a risk factor for dementia, but its role in the tra...
Determinants of accuracy in frame-based stereoelectroencephalography: the role of experience, workflow, and selective use of guiding devices
BackgroundStereoelectroencephalography (sEEG) is an essential diagnostic procedure for patients with drug-resistant epilep...
Identifying knowledge gaps in reproductive health management for women with multiple sclerosis and healthcare professionals: a scoping review
Research indicates that pregnancy does not negatively impact the long-term progression of multiple sclerosis (MS); however...
Unraveling Alzheimer’s disease: insights from single-cell sequencing and spatial transcriptomic
Unraveling Alzheimer’s disease: insights from single-cell sequencing and spatial transcriptomic
1 Introduction Alzheimer’s disease (AD) is the most common form of dementia, affecting millions worldwide, with prevalen...
Trends and hotspots of stereoelectroencephalogram from 2002 to 2023: a bibliometric analysis
Introduction Stereoelectroencephalography (SEEG) is a minimally invasive diagnostic approach used in preoperative evalua...
The prevalence of obstructive sleep apnea-hypopnea syndrome in patients with multiple sclerosis: a systematic review and meta-analysis
1 Introduction The primary cause of non-traumatic neurological dysfunction in young people is multiple sclerosis (MS), a...
TP53 oncogenic variants as prognostic factors in individuals with glioblastoma: a systematic review and meta-analysis
TP53 oncogenic variants as prognostic factors in individuals with glioblastoma: a systematic review and meta-analysis
1 Introduction Glioblastoma stands as the most prevalent and aggressive primary malignant tumor of the central nervous s...
Day 3 neutrophil-to-lymphocyte ratio and its derived indices predict 90-day poor outcomes following mechanical thrombectomy in acute ischemic stroke patients
1 Introduction Acute ischemic stroke (AIS) is a leading cause of mortality and disability worldwide. According to statis...
Mental imagery for addressing mechanisms underlying motor impairments in children with attention deficit hyperactivity disorder (ADHD)
1 ADHD: definitions, etiology and diagnosis Attention deficit hyperactivity disorder (ADHD) is the most common neurodeve...
Individual metabolic brain network abnormalities associated with drug-resistant mTLE vary in surgical outcomes
1 Introduction Drug-resistant mesial temporal lobe epilepsy (DR-MTLE), a predominant form of intractable epilepsy in cli...
Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors associated
1 Introduction Traumatic brain injury (TBI) is one of the leading causes of worldwide mortality, and disability (1, 2). ...
Association between psychiatric disorders and the risk of stroke: a meta-analysis of cohort studies
Introduction By 2019, stroke remained the third leading cause of disability and the second leading cause of death global...
Establishment and evaluation of a carotid artery dissection model in rats
Introduction Cerebral artery dissection (CeAD) represents a major factor causing stroke in young and middle-aged adults....
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