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Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies
Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive dege...
Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy
Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy
To investigate the relationship between Endoplasmic Reticulum Stress (ERS) and epilepsy, as well as their biological funct...
Polymer-Based Electrochemical Sensors for the Diagnosis of Neurodegenerative Diseases
Polymer-Based Electrochemical Sensors for the Diagnosis of Neurodegenerative Diseases
Acute and chronic neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer’s disease (AD), and...
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson’s Disease
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson’s Disease
Both mitochondrial dysfunction and endoplasmic reticulum stress (ERS) have been implicated in the pathogenesis of Parkinso...
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Cognitive impairment is one of the non-motor symptoms of Parkinson’s disease (PD), which may precede motor impairmen...
Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E/LDLR Double-Knockout Mice
Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E/LDLR Double-Knockout Mice
Hypercholesterolemia (Hch) is a risk factor for cerebrovascular and neurodegenerative diseases, manifesting with symptoms ...
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid plaques, neurofibrillary tangles (...
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Multiple sclerosis (MS) is the consequence of early-onset inflammatory demyelination and progressive neurodegenerative les...
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Although emotional stress and adaptive behavior are known to influence cardiovascular health, direct evidence linking them...
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in glob...
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Postpartum depression (PPD) remains a complex disorder with poorly understood genetic underpinnings. This study systematic...
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
PHF21A is a histone reader protein that recognizes unmethylated H3 lysine 4 and binds to DNA through its AT-hook motif. PH...
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Vascular dementia (VaD) is a prevalent form of dementia caused by cerebrovascular disease, leading to cognitive impairment...
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Alzheimer’s disease (AD) is a leading cause of dementia characterized by neuroinflammation and immune dysregulation....
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease associated with demyelination and microglial activation. Signifi...
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
N6-methyladenosine (m6A) modification is prevalent in the mammalian brain and functions as a significant epigenetic regula...
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating stroke subtype leading to severe sensorimotor dysfunction. Many studies sh...
The Role of Estrogen in Mitochondrial Disease
The Role of Estrogen in Mitochondrial Disease
This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber’s He...
A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury
A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is an emerging biomarker for the detection of acute intracranial pathology followin...
Patch-seq: Advances and Biological Applications
Patch-seq: Advances and Biological Applications
Multimodal analysis of gene-expression patterns, electrophysiological properties, and morphological phenotypes at the sing...
Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures
Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures
Rhythmic regulations are virtually described in all physiological processes, including central nervous system development ...
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Intracranial vascular malformations manifest on a continuum ranging from predominantly arterial to predominantly venous in...
Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
The adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. Thi...
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
Gliomas, including anaplastic gliomas (AG; grade 3) and glioblastomas (GBM; grade 4), are malignant brain tumors associate...
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
The existence of lymphatic vessels or similar clearance systems in the central nervous system (CNS) that transport nutrien...
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
It was found that ischemic stroke (IS) was associated with abnormal platelet activity and thrombosis. However, the potenti...
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
Circular RNA circSKA3 (spindle and kinetochore-related complex subunit 3) has been identified as a prognostic factor in is...
Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling
Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling
Exercise can promote adult neurogenesis and improve symptoms associated with schizophrenia and other mental disorders via ...
Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
Retinal vasoactive intestinal peptide amacrine cells (VIP-ACs) play an important role in various retinal light-mediated pa...
Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Multiple studies have shown that clinical events resulting into neonatal IL-4 over-exposure, such as asthma in early life ...
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