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Association Between miRNAs and the Diagnosis, Prognosis, and Recurrence of Patients with Meningioma: A Systematic Review
Association Between miRNAs and the Diagnosis, Prognosis, and Recurrence of Patients with Meningioma: A Systematic Review
To evaluate the diagnostic, prognostic, and recurrence-related roles of microRNAs (miRNAs) in meningioma based on expressi...
A Subset of Circulating Hemocytes Expresses Genes Indicating Neural Precursor Identity
A Subset of Circulating Hemocytes Expresses Genes Indicating Neural Precursor Identity
Adult neurogenesis in crayfish has been shown to require progenitors from an external source linked with the hematopoietic...
CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care
CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care
Intracranial infections remain a major neurocritical care challenge, causing high mortality and long-term deficits despite...
Decoding Alzheimer's Disease One Cell Class at a Time
Decoding Alzheimer's Disease One Cell Class at a Time
Multimodal imaging-based on single-cell genomics and spatial transcriptomics has shed new light on the taxonomy of genetic...
Early HMGB1 Inhibition Reduces Hippocampal Injury During Adolescence in a Young Mouse Model of Radiation-Induced Brain Injury
Early HMGB1 Inhibition Reduces Hippocampal Injury During Adolescence in a Young Mouse Model of Radiation-Induced Brain Injury
Radiotherapy is a primary treatment for childhood malignant brain tumors. However, it often leads to radiation-induced bra...
Repurposing Imeglimin for Chemotherapy-Induced Cognitive Impairment: Targeting Mitochondrial Dysfunction and Neuroinflammation
Repurposing Imeglimin for Chemotherapy-Induced Cognitive Impairment: Targeting Mitochondrial Dysfunction and Neuroinflammation
Chemotherapy-induced cognitive impairment, known as chemo brain, is a severe side effect of cancer treatment that may caus...
HDAC Inhibition Reshapes Splicing of Synaptic Plasticity-Related Genes and Neural Network Dynamics
HDAC Inhibition Reshapes Splicing of Synaptic Plasticity-Related Genes and Neural Network Dynamics
Alternative splicing (AS) serves as a fundamental mechanism governing proteomic diversity in brain cells throughout develo...
Immunometabolism Reframes Alzheimer’s Disease: From Systemic Dysmetabolism to Glial Rewiring
Immunometabolism Reframes Alzheimer’s Disease: From Systemic Dysmetabolism to Glial Rewiring
Alzheimer’s disease (AD) is increasingly recognized as a disorder of dysregulated immunometabolism at the neurovascu...
Entorhinal Cholecystokinin in Alzheimer’s Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model
Entorhinal Cholecystokinin in Alzheimer’s Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. The entorhi...
Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis
Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis
Alzheimer disease (AD), first described by Alzheimer and Perusini in the early twentieth century, is a devastating neurode...
Regional Molecular Diversity in Chronic Spinal Cord Injury
Regional Molecular Diversity in Chronic Spinal Cord Injury
The development of next generation cellular and acellular therapies for regenerative repair of the injured spinal cord wil...
Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation
Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation
The retina—an extension of the central nervous system—contains microglia that survey and respond to injury or ...
Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies
Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive dege...
Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy
Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy
To investigate the relationship between Endoplasmic Reticulum Stress (ERS) and epilepsy, as well as their biological funct...
Polymer-Based Electrochemical Sensors for the Diagnosis of Neurodegenerative Diseases
Polymer-Based Electrochemical Sensors for the Diagnosis of Neurodegenerative Diseases
Acute and chronic neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer’s disease (AD), and...
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson’s Disease
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson’s Disease
Both mitochondrial dysfunction and endoplasmic reticulum stress (ERS) have been implicated in the pathogenesis of Parkinso...
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Cognitive impairment is one of the non-motor symptoms of Parkinson’s disease (PD), which may precede motor impairmen...
Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E/LDLR Double-Knockout Mice
Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E/LDLR Double-Knockout Mice
Hypercholesterolemia (Hch) is a risk factor for cerebrovascular and neurodegenerative diseases, manifesting with symptoms ...
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid plaques, neurofibrillary tangles (...
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Multiple sclerosis (MS) is the consequence of early-onset inflammatory demyelination and progressive neurodegenerative les...
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Although emotional stress and adaptive behavior are known to influence cardiovascular health, direct evidence linking them...
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in glob...
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Postpartum depression (PPD) remains a complex disorder with poorly understood genetic underpinnings. This study systematic...
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
PHF21A is a histone reader protein that recognizes unmethylated H3 lysine 4 and binds to DNA through its AT-hook motif. PH...
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Vascular dementia (VaD) is a prevalent form of dementia caused by cerebrovascular disease, leading to cognitive impairment...
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Alzheimer’s disease (AD) is a leading cause of dementia characterized by neuroinflammation and immune dysregulation....
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease associated with demyelination and microglial activation. Signifi...
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
N6-methyladenosine (m6A) modification is prevalent in the mammalian brain and functions as a significant epigenetic regula...
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating stroke subtype leading to severe sensorimotor dysfunction. Many studies sh...
The Role of Estrogen in Mitochondrial Disease
The Role of Estrogen in Mitochondrial Disease
This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber’s He...
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