Ahmad F, Sun Q, Patel D, Stommel JM (2019) Cholesterol metabolism: a potential therapeutic target in glioblastoma. Cancers (Basel). https://doi.org/10.3390/CANCERS11020146

Article  PubMed  PubMed Central  Google Scholar 

Ajoolabady A, Bi Y, McClements DJ et al (2022) Melatonin-based therapeutics for atherosclerotic lesions and beyond: focusing on macrophage mitophagy. Pharmacol Res. https://doi.org/10.1016/J.PHRS.2022.106072

Article  PubMed  PubMed Central  Google Scholar 

Asadi M, Taghizadeh S, Kaviani E et al (2022) Caspase-3: structure, function, and biotechnological aspects. Biotechnol Appl Biochem 69:1633–1645. https://doi.org/10.1002/BAB.2233

Article  CAS  PubMed  Google Scholar 

Bahrami A, Liberale L, Reiner Ž et al (2020) Inflammatory biomarkers for cardiovascular risk stratification in familial hypercholesterolemia. Rev Physiol Biochem Pharmacol 177:25–52. https://doi.org/10.1007/112_2020_26/COVER

Article  CAS  PubMed  Google Scholar 

Bano D, Prehn JHM (2018) Apoptosis-inducing factor (AIF) in physiology and disease: the tale of a repented natural born killer. EBioMedicine 30:29–37. https://doi.org/10.1016/J.EBIOM.2018.03.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes-Vélez JA, Aksoy Yasar FB, Hu J (2023) Myelin lipid metabolism and its role in myelination and myelin maintenance. Innov 4:100360. https://doi.org/10.1016/J.XINN.2022.100360

Article  Google Scholar 

Bartekova M, Radosinska J, Jelemensky M, Dhalla NS (2018) Role of cytokines and inflammation in heart function during health and disease. Heart Fail Rev 23:733–758. https://doi.org/10.1007/S10741-018-9716-X

Article  CAS  PubMed  Google Scholar 

Berghoff SA, Spieth L, Saher G (2022) Local cholesterol metabolism orchestrates remyelination. Trends Neurosci 45:272–283. https://doi.org/10.1016/J.TINS.2022.01.001

Article  CAS  PubMed  Google Scholar 

Black SM, Benson BA, Idossa D et al (2011) Protection of porcine endothelial cells against apoptosis with interleukin-4. Xenotransplantation 18:343. https://doi.org/10.1111/J.1399-3089.2011.00678.X

Article  PubMed  PubMed Central  Google Scholar 

Bonvento G, Bolaños JP (2021) Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metab 33:1546–1564. https://doi.org/10.1016/J.CMET.2021.07.006

Article  CAS  PubMed  Google Scholar 

Brahadeeswaran S, Sivagurunathan N, Calivarathan L (2022) Inflammasome signaling in the aging brain and age-related neurodegenerative diseases. Mol Neurobiol 59:2288–2304. https://doi.org/10.1007/S12035-021-02683-5

Article  CAS  PubMed  Google Scholar 

Cao C, Arendash GW, Dickson A et al (2009) Aβ-specific Th2 cells provide cognitive and pathological benefits to Alzheimer’s mice without infiltrating the CNS. Neurobiol Dis 34:63–70. https://doi.org/10.1016/J.NBD.2008.12.015

Article  PubMed  PubMed Central  Google Scholar 

Cavaglia M, Dombrowski SM, Drazba J et al (2001) Regional variation in brain capillary density and vascular response to ischemia. Brain Res 910:81–93. https://doi.org/10.1016/S0006-8993(01)02637-3

Article  CAS  PubMed  Google Scholar 

Chen SY, Chen TF, Lai LC et al (2012) Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer’s disease. J Neuroinflamm 9:1–9. https://doi.org/10.1186/1742-2094-9-21/FIGURES/2_536

Article  CAS  Google Scholar 

Chen YL, Wang LM, Chen Y et al (2016a) Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience 316:178–191. https://doi.org/10.1016/J.NEUROSCIENCE.2015.12.039

Article  CAS  PubMed  Google Scholar 

Chen Y, Yin M, Cao X et al (2018) Pro- and anti-inflammatory: effects of high cholesterol diet on aged brain. Aging Dis 9:374. https://doi.org/10.14336/AD.2017.0706

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Zhang X, Millican R et al (2022) Recent progress in in vitro models for atherosclerosis studies. Front Cardiovasc Med. https://doi.org/10.3389/FCVM.2021.790529

Article  PubMed  PubMed Central  Google Scholar 

Ciryam P, Gerzanich V, Simard JM (2023) Interleukin-6 in traumatic brain injury: a Janus-faced player in damage and repair. J Neurotrauma 40:2249–2269. https://doi.org/10.1089/NEU.2023.0135

Article  PubMed  PubMed Central  Google Scholar 

Cochrane A, Albers HJ, Passier R et al (2019) Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology. Adv Drug Deliv Rev 140:68–77. https://doi.org/10.1016/J.ADDR.2018.06.007

Article  CAS  PubMed  Google Scholar 

Collado A, Marques P, Domingo E et al (2019) Novel immune features of the systemic inflammation associated with primary hypercholesterolemia: changes in cytokine/chemokine profile, increased platelet and leukocyte activation. J Clin Med 8:18. https://doi.org/10.3390/JCM8010018

Article  CAS  Google Scholar 

Cui P, Wang S (2019) Application of microfluidic chip technology in pharmaceutical analysis: a review. J Pharm Anal 9:238–247. https://doi.org/10.1016/J.JPHA.2018.12.001

Article  PubMed  Google Scholar 

Czuba E, Steliga A, Lietzau G, Kowiański P (2017) Cholesterol as a modifying agent of the neurovascular unit structure and function under physiological and pathological conditions. Metab Brain Dis 2:1–14

Google Scholar 

DaSilva KA, Brown ME, Westaway D, McLaurin JA (2006) Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology. Neurobiol Dis 23:433–444. https://doi.org/10.1016/J.NBD.2006.03.013

Article  CAS  PubMed  Google Scholar 

de Baat A, Trinh B, Ellingsgaard H, Donath MY (2023) Physiological role of cytokines in the regulation of mammalian metabolism. Trends Immunol 44:613–627. https://doi.org/10.1016/J.IT.2023.06.002

Article  PubMed  Google Scholar 

de Bem AF, Krolow R, Farias HR et al (2021) Animal models of metabolic disorders in the study of neurodegenerative diseases: an overview. Front Neurosci 14:1457

Google Scholar 

de Dios C, Abadin X, Roca-Agujetas V et al (2023) Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis. Transl Neurodegener 12:1–23. https://doi.org/10.1186/S40035-023-00343-3/FIGURES/9

Article  Google Scholar 

de Oliveira J, Hort MA, Moreira ELG et al (2011) Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 197:99–106. https://doi.org/10.1016/J.NEUROSCIENCE.2011.09.009

Article  PubMed  Google Scholar 

De Oliveira J, Moreira ELG, Dos Santos DB et al (2014) Increased susceptibility to amyloid-β-induced neurotoxicity in mice lacking the low-density lipoprotein receptor. J Alzheimer’s Dis 41:43–60. https://doi.org/10.3233/JAD-132228

Article  CAS  Google Scholar 

De Oliveira J, Engel DF, De Paula GC et al (2020a) LDL receptor deficiency does not alter brain amyloid-β levels but causes an exacerbation of apoptosis. J Alzheimers Dis 73:585–596. https://doi.org/10.3233/JAD-190742

Article  CAS  PubMed  Google Scholar 

De Oliveira J, Engel DF, De Paula GC et al (2020b) High cholesterol diet exacerbates blood-brain barrier disruption in lDLr–/– mice: impact on cognitive function. J Alzheimer’s Dis 78:97. https://doi.org/10.3233/JAD-200541

Article  CAS  Google Scholar 

Derecki NC, Cardani AN, Yang CH et al (2010) Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207:1067. https://doi.org/10.1084/JEM.20091419

Article  CAS