Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study

Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke 24(1):35–41. https://doi.org/10.1161/01.str.24.1.35

Article  PubMed  Google Scholar 

Analitis A, Katsouyanni K, Biggeri A, Baccini M, Forsberg B, Bisanti L, Kirchmayer U, Ballester F, Cadum E, Goodman PG, Hojs A, Sunyer J, Tiittanen P, Michelozzi P (2008) Effects of cold weather on mortality: results from 15 European cities within the PHEWE project. Am J Epidemiol 168(12):1397–1408. https://doi.org/10.1093/aje/kwn266

Article  CAS  PubMed  Google Scholar 

Berges IM, Seale G, Ostir GV (2011) Positive affect and pain ratings in persons with stroke. Rehabil Psychol 56(1):52–57. https://doi.org/10.1037/a0022683

Article  PubMed  PubMed Central  Google Scholar 

Boehm JK, Kubzansky LD (2012) The heart’s content: the association between positive psychological well-being and cardiovascular health. Psychol Bull 138(4):655–691. https://doi.org/10.1037/a0027448

Article  PubMed  Google Scholar 

Boltwood MD, Taylor CB, Burke MB, Grogin H, Giacomini J (1993) Anger report predicts coronary artery vasomotor response to mental stress in atherosclerotic segments. Am J Cardiol 72(18):1361–1365. https://doi.org/10.1016/0002-9149(93)90180-k

Article  CAS  PubMed  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Braunwald E (1998) Unstable angina: an etiologic approach to management. Circulation 98(21):2219–2222. https://doi.org/10.1161/01.cir.98.21.2219

Article  CAS  PubMed  Google Scholar 

Burgess S, Thompson SG (2015) Multivariable mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol 181(4):251–260. https://doi.org/10.1093/aje/kwu283

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37(7):658–665. https://doi.org/10.1002/gepi.21758

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Foley CN, Zuber V (2018) Inferring causal relationships between risk factors and outcomes from genome-wide association study data. Annu Rev Genomics Hum Genet 19:303–327. https://doi.org/10.1146/annurev-genom-083117-021731

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chida Y, Steptoe A (2008) Positive psychological well-being and mortality: a quantitative review of prospective observational studies. Psychosom Med 70(7):741–756. https://doi.org/10.1097/PSY.0b013e31818105ba

Article  PubMed  Google Scholar 

Collaborators GBDS (2021) Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol 20(10):795–820. https://doi.org/10.1016/S1474-4422(21)00252-0

Article  Google Scholar 

Craske MG, Rauch SL, Ursano R, Prenoveau J, Pine DS, Zinbarg RE (2009) What is an anxiety disorder? Depress Anxiety 26(12):1066–1085. https://doi.org/10.1002/da.20633

Article  PubMed  Google Scholar 

Edmondson D, Newman JD, Whang W, Davidson KW (2013) Emotional triggers in myocardial infarction: do they matter? Eur Heart J 34(4):300–306. https://doi.org/10.1093/eurheartj/ehs398

Article  PubMed  Google Scholar 

Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M (2022) Cardiac risk factors for stroke: a comprehensive Mendelian randomization study. Stroke 53(4):e130–e135. https://doi.org/10.1161/STROKEAHA.121.036306

Article  PubMed  Google Scholar 

Gross C, Hen R (2004) The developmental origins of anxiety. Nat Rev Neurosci 5(7):545–552. https://doi.org/10.1038/nrn1429

Article  CAS  PubMed  Google Scholar 

Guiraud V, Amor MB, Mas JL, Touze E (2010) Triggers of ischemic stroke: a systematic review. Stroke 41(11):2669–2677. https://doi.org/10.1161/STROKEAHA.110.597443

Article  PubMed  Google Scholar 

Hackett RA, Poole L, Hunt E, Panagi L, Steptoe A (2019) Loneliness and biological responses to acute stress in people with type 2 diabetes. Psychophysiology 56(6):e13341. https://doi.org/10.1111/psyp.13341

Article  PubMed  PubMed Central  Google Scholar 

Kotlega D, Golab-Janowska M, Masztalewicz M, Ciecwiez S, Nowacki P (2016) The emotional stress and risk of ischemic stroke. Neurol Neurochir Pol 50(4):265–270. https://doi.org/10.1016/j.pjnns.2016.03.006

Article  PubMed  Google Scholar 

Lambiase MJ, Kubzansky LD, Thurston RC (2015) Positive psychological health and stroke risk: the benefits of emotional vitality. Health Psychol 34(10):1043–1046. https://doi.org/10.1037/hea0000228

Article  PubMed  Google Scholar 

Li H, Xia N (2020) The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness. Redox Biol 37:101585. https://doi.org/10.1016/j.redox.2020.101585

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Q, Li R, Wang L, Yin P, Wang Y, Yan C, Ren Y, Qian Z, Vaughn MG, McMillin SE, Hay SI, Naghavi M, Cai M, Wang C, Zhang Z, Zhou M, Lin H, Yang Y (2021) Temporal trend and attributable risk factors of stroke burden in China, 1990–2019: an analysis for the global burden of disease study 2019. Lancet Public Health 6(12):e897–e906. https://doi.org/10.1016/S2468-2667(21)00228-0

Article  PubMed  PubMed Central  Google Scholar 

Mittleman MA, Mostofsky E (2011) Physical, psychological and chemical triggers of acute cardiovascular events: preventive strategies. Circulation 124(3):346–354. https://doi.org/10.1161/CIRCULATIONAHA.110.968776

Article  PubMed  PubMed Central  Google Scholar 

Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE (1995) Triggering of acute myocardial infarction onset by episodes of anger. Determinants of myocardial infarction onset study investigators. Circulation 92(7):1720–1725. https://doi.org/10.1161/01.cir.92.7.1720

Article  CAS  PubMed  Google Scholar 

Muller JE, Tofler GH, Stone PH (1989) Circadian variation and triggers of onset of acute cardiovascular disease. Circulation 79(4):733–743. https://doi.org/10.1161/01.cir.79.4.733

Article  CAS  PubMed  Google Scholar 

Muller JE, Kaufmann PG, Luepker RV, Weisfeldt ML, Deedwania PC, Willerson JT (1997) Mechanisms precipitating acute cardiac events: review and recommendations of an NHLBI workshop. National heart, lung, and blood institute. Mechanisms precipitating acute cardiac events participants. Circulation 96(9):3233–3239. https://doi.org/10.1161/01.cir.96.9.3233

Article  CAS  PubMed  Google Scholar 

O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A, Weimar C, Wang X, Yusuf S (2010) Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 376(9735):112–123. https://doi.org/10.1016/S0140-6736(10)60834-3

Article  PubMed  Google Scholar 

Ostir GV, Markides KS, Peek MK, Goodwin JS (2001) The association between emotional well-being and the incidence of stroke in older adults. Psychosom Med 63(2):210–215. https://doi.org/10.1097/00006842-200103000-00003

Article  CAS  PubMed  Google Scholar 

Peng K, Li Y, Adegboro AA, Wanggou S, Li X (2023) Mood swings are causally associated with intracranial aneurysm subarachnoid hemorrhage: a Mendelian randomization study. Brain Behav 13(11):e3233. https://doi.org/10.1002/brb3.3233

Article 

Comments (0)

No login
gif