Alfaro-Ruiz R, Martín-Belmonte A, Aguado C, Moreno-Martínez AE, Fukazawa Y, Luján R (2024) Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology. Biol Res 57(1):56. https://doi.org/10.1186/s40659-024-00537-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen BL, Taatjes DJ (2015) The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol 16(3):155–166. https://doi.org/10.1038/nrm3951

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartoli M, Palermo S, Stanziano M, Cipriani GE, Leotta D, Valentini MC, Amanzio M (2020) Reduced self-awareness following a combined polar and paramedian bilateral thalamic infarction. A possible relationship with SARS-CoV-2 risk of contagion? Front Psycho 11:570160. https://doi.org/10.3389/fpsyg.2020.570160

Article  Google Scholar 

Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R’Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH (2022) APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature 611(7937):769–779. https://doi.org/10.1038/s41586-022-05439-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bor Tekdemir Z, Seckin AI, Kacar T, Yilmaz E, Bekiroglu S (2020) Evaluation of structural, biological, and functional similarity of biosimilar granulocyte colony stimulating factor to its reference product. Pharm Res 37(11):215. https://doi.org/10.1007/s11095-020-02932-7

Article  CAS  PubMed  Google Scholar 

Bourgeron T (2007) The possible interplay of synaptic and clock genes in autism spectrum disorders. Cold Spring Harb Symp Quant Biol 72:645–654. https://doi.org/10.1101/sqb.2007.72.020

Article  CAS  PubMed  Google Scholar 

Cevher MA, Shi Y, Li D, Chait BT, Malik S, Roeder RG (2014) Reconstitution of active human core mediator complex reveals a critical role of the MED14 subunit. Nat Struct Mol Biol 21(12):1028–1034. https://doi.org/10.1038/nsmb.2914

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collaborators GDF (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet Public Health 7(2):e105–e125. https://doi.org/10.1016/s2468-2667(21)00249-8

Article  Google Scholar 

Davies NM, Howe LJ, Brumpton B, Havdahl A, Evans DM, Davey Smith G (2019) Within family Mendelian randomization studies. Hum Mol Genet 28(R2):R170-r179. https://doi.org/10.1093/hmg/ddz204

Article  CAS  PubMed  Google Scholar 

Ehtewish H, Mesleh A, Ponirakis G, De la Fuente A, Parray A, Bensmail I, Abdesselem H, Ramadan M, Khan S, Chandran M, Ayadathil R, Elsotouhy A, Own A, Al Hamad H, Abdelalim EM, Decock J, Alajez NM, Albagha O, Thornalley PJ, Arredouani A, Malik RA, El-Agnaf OMA (2023) Blood-based proteomic profiling identifies potential biomarker candidates and pathogenic pathways in dementia. Int J Mol Sci. https://doi.org/10.3390/ijms24098117

Article  PubMed  PubMed Central  Google Scholar 

Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, Gunnarsdottir K, Helgason A, Oddsson A, Halldorsson BV, Jensson BO, Zink F, Halldorsson GH, Masson G, Arnadottir GA, Katrinardottir H, Juliusson K, Magnusson MK, Magnusson OT, Fridriksdottir R, Saevarsdottir S, Gudjonsson SA, Stacey SN, Rognvaldsson S, Eiriksdottir T, Olafsdottir TA, Steinthorsdottir V, Tragante V, Ulfarsson MO, Stefansson H, Jonsdottir I, Holm H, Rafnar T, Melsted P, Saemundsdottir J, Norddahl GL, Lund SH, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53(12):1712–1721. https://doi.org/10.1038/s41588-021-00978-w

Article  CAS  PubMed  Google Scholar 

Freeman OJ, Mallucci GR (2016) The UPR and synaptic dysfunction in neurodegeneration. Brain Res 1648(Pt B):530–537. https://doi.org/10.1016/j.brainres.2016.03.029

Article  CAS  PubMed  Google Scholar 

Gao X, Li Q, Chen G, He H, Ma Y (2020) MAGEA3 promotes proliferation and suppresses apoptosis in cervical cancer cells by inhibiting the KAP1/p53 signaling pathway. Am J Transl Res 12(7):3596–3612

CAS  PubMed  PubMed Central  Google Scholar 

Gao YF, Jin TY, Chen Y, Ding YH (2023) No causal genetic relationships between atrial fibrillation and vascular dementia: a bidirectional Mendelian randomization study. Front Cardiovas Med 10:1071574. https://doi.org/10.3389/fcvm.2023.1071574

Article  CAS  Google Scholar 

Garcia-Bonilla L, Racchumi G, Murphy M, Anrather J, Iadecola C (2015) Endothelial CD36 contributes to postischemic brain injury by promoting neutrophil activation via CSF3. J Neurosci 35(44):14783–14793. https://doi.org/10.1523/jneurosci.2980-15.2015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaspar L, Howald C, Popadin K, Maier B, Mauvoisin D, Moriggi E, Gutierrez-Arcelus M, Falconnet E, Borel C, Kunz D, Kramer A, Gachon F, Dermitzakis ET, Antonarakis SE, Brown SA (2017) The genomic landscape of human cellular circadian variation points to a novel role for the signalosome. Elife. https://doi.org/10.7554/eLife.24994

Article  PubMed  PubMed Central  Google Scholar 

Gómez Ravetti M, Rosso OA, Berretta R, Moscato P (2010) Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus’ gene expression profiles in Alzheimer’s disease. PLoS ONE 5(4):e10153. https://doi.org/10.1371/journal.pone.0010153

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife. https://doi.org/10.7554/eLife.34408

Article  PubMed  PubMed Central  Google Scholar 

Hu WT, Howell JC, Ozturk T, Gangishetti U, Kollhoff AL, Hatcher-Martin JM, Anderson AM, Tyor WR (2019) CSF cytokines in aging, multiple sclerosis, and dementia. Front Immunol 10:480. https://doi.org/10.3389/fimmu.2019.00480

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, Zhao J, Lin Z, Wang Y, Peng H, Zhao H, Wan X, Yang C (2022) Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proc Natl Acad Sci USA 119(28):e2106858119. https://doi.org/10.1073/pnas.2106858119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang I, Choi YS, Jeon MY, Jeong S (2010) NF-κB p65 represses β-catenin-activated transcription of cyclin D1. Biochem Biophys Res Commun 403(1):79–84. https://doi.org/10.1016/j.bbrc.2010.10.118

Article  CAS  PubMed  Google Scholar 

Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P (2011) SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1. Cell 147(7):1601–1614. https://doi.org/10.1016/j.cell.2011.11.028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito J, Nagayasu Y, Miura Y, Yokoyama S, Michikawa M (2014) Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1. Brain Res 1570:1–12. https://doi.org/10.1016/j.brainres.2014.04.037

Article  CAS  PubMed  Google Scholar 

Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, Li Y, Li Y, Zhu M, Jiao H, Song Y, Shi Y, Zhang H, Gong M, Wei C, Tang Y, Fang B, Guo D, Wang F, Zhou A, Chu C, Zuo X, Yu Y, Yuan Q, Wang W, Li F, Shi S, Yang H, Zhou C, Liao Z, Lv Y, Li Y, Kan M, Zhao H, Wang S, Yang S, Li H, Liu Z, Wang Q, Qin W, Jia J (2020) Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet Public Health 5(12):e661–e671. https://doi.org/10.1016/s2468-2667(20)30185-7

Article  PubMed  Google Scholar 

LaConte LE, Chavan V, Liang C, Willis J, Schonhense EM, Schoch S, Mukherjee K (2016) CASK stabilizes neurexin and links it to liprin-alpha in a neuronal activity-dependent manner. Cell Mol Life Sci 73(18):3599–3621. https://doi.org/10.1007/s00018-016-2183-4

Article  CAS  PubMed  PubMed Central