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Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration
Oxysterols, oxidized derivatives of cholesterol, are key modulators of central nervous system (CNS) function. Acting as bo...
T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers
Background and objectivesFMR1 premutation carriers (55–200 CGG repeats) are at risk of developing fragile X-associated tre...
Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations
IntroductionTemporal lobe epilepsy is the most prevalent form of drug-resistant focal epilepsy and is frequently associate...
Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice
Peroxisomes are dynamic organelles that play a crucial role in cellular metabolism, particularly in fatty acid degradation...
Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020–2025)
IntroductionSubstance use disorder (SUD) is a complex neurobiological disorder characterized by the consolidation of malad...
Clinical and genetic determinants of glioblastoma survival: a retrospective study
BackgroundThis study analyzed 57 patients with glioblastoma treated at the General University Hospital of Castellon, Spain...
Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at t...
Lactate and cognition: a dual modulator
Lactate, traditionally regarded as a byproduct of glycolysis, has emerged as a key metabolic substrate and signaling molec...
Notch signaling inhibition attenuates epileptogenesis and hippocampal damage without altering mossy fiber sprouting in adolescent rats post-status epilepticus
BackgroundNotch overactivation and aberrant neurogenesis following status epilepticus (SE) has been identified by our prev...
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer’s disease pathogenesis
IntroductionApolipoprotein E (ApoE), reelin, and several other proteins bind ApoE-receptor 2 (apoER2), distinguished from ...
Integrating neural organoids and AI: increasing the risk of artificial consciousness or medical malpractice?
Neural organoids can be integrated with AI models in various formats, termed AI-NO systems. Neural organoids and AI are ea...
Mediterranean diet and gut microbiota: impact on memory and other cognitive functions: a systematic review
In recent years, there has been growing interest in the study of gut microbiota and its relationship with multiple disease...
Mentorship, memory, and honor: Rita Levi-Montalcini’s legacy and the role of academic recognition in promoting women in science
The contemporary vignette highlights how the mentorship model exemplified by Rita Levi-Montalcini continues to foster scie...
Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-mediated neuroprotection after stroke
IntroductionNeuregulin-1 (NRG-1) is a growth factor that has been investigated for its neuroprotective properties followin...
Retraction: Selected thiadiazine-thione derivatives attenuate neuroinflammation in chronic constriction injury induced neuropathy
A Retraction of the Original Research Article Selected thiadiazine-thione derivatives attenuate neuroinflammation in chron...
TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis
Mislocalization and aggregation of the DNA/RNA binding protein, TDP-43, is seen in most cases of amyotrophic lateral scler...
Polyclonal glycine receptor aAbs: a challenge for personalized epitope characterization
IntroductionPatients with glycine receptor (GlyR) aAbs suffer from various diseases, including stiff-person syndrome (SPS)...
Glycine transport inhibitors for the treatment of chronic pain conditions: the time is ripe for clinical evaluation!
The treatment of chronic pain is -despite intensive research -still challenging, and the outcomes for patients are in many...
Editorial: Neuroglycobiology
Neuroglycobiology sits at the intersection of neuroscience and glycobiology, focusing on how glycans and glycoconjugates s...
Increased nuclear import characterizes aberrant nucleocytoplasmic transport in neurons from patients with spinocerebellar ataxia type 7
1 Introduction Spinocerebellar ataxia type 7 (SCA7) is a hereditary autosomal dominant neurodegenerative disorder charac...
The good, the bad, and the unknown nature of decreased GD3 synthase expression
1 Introduction Gangliosides, complex glycosphingolipids, challenging to investigate with common molecular biology method...
Editorial: Regulators of synapse formation: understanding the molecular mechanisms and its dysregulation in neurodevelopmental disorders
and behavioral functions. This research topic comprises six articles that explore the latest discoveries in the molecular ...
Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons
1 Introduction A unique and fundamental characteristic of the nervous system during development is the ability of neuron...
Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors
Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors
Introduction The intracellular messengers, cyclic AMP (cAMP) and cyclic GMP (cGMP), are involved in the mechanisms of sy...
Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects
Several anti-viral drugs like those used to treat human immunodeficiency virus (HIV) infections have been associated with ...
Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevoflurane
1 Introduction Sevoflurane is an anesthetic widely used in pediatric general anesthesia, whether it is safe to applicati...
Toll-like receptors as a missing link in Notch signaling cascade during neurodevelopment
1 Notch and Toll—structural and signaling features During neurodevelopment, neural progenitor cells (NPCs) settled in th...
TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2
1 Introduction Sleep loss appears common daily and has become a global public health issue. According to the World Healt...
Cell-autonomous action of Slit2 in radial migration of cortical projection neurons
Introduction The cerebral cortex is a highly ordered brain structure with neurons organized into six distinct layers. Th...
Corrigendum: Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer's disease
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