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Divergent outcomes of delta 9 – tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice
Divergent outcomes of delta 9 – tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice
The increasing exposure to delta 9-tetrahydrocannabinol (THC) in youth sparks concerns about disruption of ongoing neurode...
Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study
Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study
Depression is associated with numerous metabolic pathway abnormalities, and several studies have suggested a link between ...
Chemogenetic activation of medial prefrontal cortex projections to the nucleus accumbens shell suppresses cocaine-primed reinstatement in EcoHIV infected mice
Chemogenetic activation of medial prefrontal cortex projections to the nucleus accumbens shell suppresses cocaine-primed reinstatement in EcoHIV infected mice
HIV is highly comorbid with cocaine use disorder (CUD). Relapse is a major challenge in the treatment of CUD, and people l...
Effect of genetic deletion of nociceptin/orphanin FQ receptors on spatial and associative memory in rats
Effect of genetic deletion of nociceptin/orphanin FQ receptors on spatial and associative memory in rats
A growing body of evidence suggests that the N/OFQ-NOP receptor system modulates learning and memory in rodents, with NOP ...
Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice
Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice
Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, ...
Post-methamphetamine working memory decline predicts relapse vulnerability in rats and is rescued by mGlu3 receptor activation
Post-methamphetamine working memory decline predicts relapse vulnerability in rats and is rescued by mGlu3 receptor activation
Widespread methamphetamine (meth) misuse remains a worldwide public health issue that lacks effective clinical treatment. ...
The impact of anti-craving medication on cue reactivity and abstinence in patients undergoing alcohol detoxification: some preliminary evidence from a retrospective event-related potentials study
The impact of anti-craving medication on cue reactivity and abstinence in patients undergoing alcohol detoxification: some preliminary evidence from a retrospective event-related potentials study
While medications such as acamprosate, baclofen, or naltrexone have shown promising effects in the treatment of alcohol us...
Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats
Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats
Alcohol use disorder (AUD) remains a major public health challenge, yet effective pharmacotherapies are limited. As such, ...
96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like use
96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like use
Methamphetamine is a psychostimulant with significant public health implications. Chronic methamphetamine use is linked to...
Effects of acute alcohol administration on endocannabinoids and relation to subjective effects
Effects of acute alcohol administration on endocannabinoids and relation to subjective effects
Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective ef...
The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction
The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction
Nicotine and cigarette/tobacco use continue to be a prevalent public health issue worldwide. The transition to nicotine ad...
ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO-induced panic behavior
ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO-induced panic behavior
There is a connection between respiratory pathologies and panic disorder, since episodes of hypercapnia can trigger anxiet...
Attentional bias in young adult tobacco cigarette smokers and e-cigarette users: an eye-tracking study
Attentional bias in young adult tobacco cigarette smokers and e-cigarette users: an eye-tracking study
Attentional bias (AB) is a key behavioural feature known to contribute to the maintenance of tobacco use; however, little ...
Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review
Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review
Postnatal neurogenesis is the process of new nerve cell formation that occurs after birth. The disruption of the neurogene...
Methylphenidate leads to disruptions in rest/wake patterns after discontinuation
Methylphenidate leads to disruptions in rest/wake patterns after discontinuation
Children with attention-deficit/hyperactivity disorder (ADHD) experience more sleep problems than their peers. As stimulan...
The effects of orally ingested Delta-9-Tetrahydrocannabinol on drivers’ hazard perception and risk-taking behaviours: A within-subjects study of medicinal cannabis users
The effects of orally ingested Delta-9-Tetrahydrocannabinol on drivers’ hazard perception and risk-taking behaviours: A within-subjects study of medicinal cannabis users
Medicinal cannabis use is increasing worldwide, yet its impacts on driving safety in frequent users are not clearly unders...
Virtual reality environmental enrichment effects on heart rate variability in healthy volunteers
Virtual reality environmental enrichment effects on heart rate variability in healthy volunteers
Environmental enrichment (EE) is a nonpharmacological approach widely used in preclinical studies and only recently applie...
Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC
Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC
Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studie...
Methylphenidate (Ritalin) does not improve exam performance in an experimental setting
Methylphenidate (Ritalin) does not improve exam performance in an experimental setting
Surveys indicate that about 10–20% of students use medicinal drugs to improve their exam performance. Whether these ...
Fear generalization modulated by shock intensity and protein synthesis inhibitor
Fear generalization modulated by shock intensity and protein synthesis inhibitor
Maladaptive fear responses, including sensitized threat reactions and overgeneralization, contribute to anxiety disorders ...
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
G-protein biased mu-opioid receptor (MOR) agonists have been reported to exhibit superior therapeutic windows compared to ...
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Alcohol consumption despite negative consequences is a core symptom of Alcohol Use Disorder. In animal models, this is stu...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mech...
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
Prenatal maternal immune activation (MIA) is an etiological risk factor for schizophrenia in offspring. Recently, parvalbu...
SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting
SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting
Psychostimulants, such as amphetamine (AMPH) and methylphenidate (MPH), non-selectively elevate extracellular concentratio...
Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring
Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring
The prevalence of newborns exposed to medications for opioid use disorder (MOUD), such as methadone or buprenorphine, duri...
Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task
Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task
Alcohol-intoxication is implicated in negative social behaviours, however the mechanisms underlying this relationship are ...
Seeking under threat of adversity: assessing control over reward pursuit in rats
Seeking under threat of adversity: assessing control over reward pursuit in rats
Substance use disorder (SUD) is a chronic relapsing brain disorder that is characterised by loss of control over substance...
Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior
Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior
Adolescent inhalant use is an understudied and undertreated disorder, particularly in females. Chronic exposure to inhalan...
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