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Fear generalization modulated by shock intensity and protein synthesis inhibitor
Fear generalization modulated by shock intensity and protein synthesis inhibitor
Maladaptive fear responses, including sensitized threat reactions and overgeneralization, contribute to anxiety disorders ...
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
G-protein biased mu-opioid receptor (MOR) agonists have been reported to exhibit superior therapeutic windows compared to ...
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Alcohol consumption despite negative consequences is a core symptom of Alcohol Use Disorder. In animal models, this is stu...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mech...
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
Prenatal maternal immune activation (MIA) is an etiological risk factor for schizophrenia in offspring. Recently, parvalbu...
SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting
SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting
Psychostimulants, such as amphetamine (AMPH) and methylphenidate (MPH), non-selectively elevate extracellular concentratio...
Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring
Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring
The prevalence of newborns exposed to medications for opioid use disorder (MOUD), such as methadone or buprenorphine, duri...
Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task
Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task
Alcohol-intoxication is implicated in negative social behaviours, however the mechanisms underlying this relationship are ...
Seeking under threat of adversity: assessing control over reward pursuit in rats
Seeking under threat of adversity: assessing control over reward pursuit in rats
Substance use disorder (SUD) is a chronic relapsing brain disorder that is characterised by loss of control over substance...
Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior
Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior
Adolescent inhalant use is an understudied and undertreated disorder, particularly in females. Chronic exposure to inhalan...
Substance use disorder severity is associated with sensitivity to effort-related decision-making constraints
Substance use disorder severity is associated with sensitivity to effort-related decision-making constraints
Several studies have reported associations between substance use and effort-related decision making, or the degree to whic...
Safety and efficacy of dasotraline for patients with attention deficit/hyperactivity disorder: a systematic review and meta-analysis of 1594 patients including GRADE qualifications
Safety and efficacy of dasotraline for patients with attention deficit/hyperactivity disorder: a systematic review and meta-analysis of 1594 patients including GRADE qualifications
Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder. It is one of the most common men...
Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies
Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies
Major depressive disorder (MDD) is a common and serious psychiatric disorder associated with significant morbidity. There ...
Working memory processes and the histamine-3 receptor in schizophrenia: a [11C]MK-8278 PET-fMRI study
Working memory processes and the histamine-3 receptor in schizophrenia: a [11C]MK-8278 PET-fMRI study
Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclin...
Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug
Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug
The positive reinforcing effects of alcohol (ethanol) drive repetitive use and contribute to alcohol use disorder (AUD). E...
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
While morphine has important therapeutic value it is also one of the most widely abused drugs in the world. As a newly dis...
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, persona...
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
In bipolar disorder (BD), immunological factors play a role in the pathogenesis and treatment of the illness. Studies show...
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
Screening novel medications for alcohol use disorder (AUD) requires models that are both efficient and ecologically-valid....
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner
Ischemic stroke still ranks as the most fatal disease worldwide. Blood-brain barrier (BBB) is a promising therapeutic targ...
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
Cigarette smoking is one of the leading preventable causes of premature death worldwide. There is evidence in the literatu...
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
Alcohol use disorder (AUD) is a debilitating physiological and psychiatric disorder which affects individuals globally. Th...
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
Win-paired stimuli can promote risk taking in experimental gambling paradigms in both rats and humans. We previously demon...
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
Relapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seekin...
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
Substance use disorders (SUDs) rank among the most severely debilitating psychiatric conditions. Among others, decreased r...
Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
Both animal and human studies, though limited, showed that multi-strain probiotic supplementation may reduce the number of...
Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats
Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats
Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the r...
Liraglutide ameliorates delirium-like behaviors of aged mice undergoing cardiac surgery by mitigating microglia activation via promoting mitophagy
Liraglutide ameliorates delirium-like behaviors of aged mice undergoing cardiac surgery by mitigating microglia activation via promoting mitophagy
Postoperative delirium (POD) is a prevalent complication in cardiac surgery patients, particularly the elderly, with neuro...
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