Adams WK, Levesque DL, Cocker PJ et al (2020) Decreased motor impulsivity following chronic lithium treatment in male rats is associated with reduced levels of pro-inflammatory cytokines in the orbitofrontal cortex. Brain Behav Immun 89:339–349. https://doi.org/10.1016/j.bbi.2020.07.018
Alcocer-Gómez E, de Miguel M, Casas-Barquero N et al (2014) NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun 36:111–117. https://doi.org/10.1016/j.bbi.2013.10.017
Alcocer-Gómez E, Casas-Barquero N, Williams MR et al (2017) Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in major depressive disorder. Pharmacol Res 121:114–121. https://doi.org/10.1016/J.PHRS.2017.04.028
Alvarez Retuerto AI, Cantor RM, Gleeson JG et al (2008) Association of common variants in the Joubert syndrome gene (AHI1) with autism. Hum Mol Genet 17:3887–3896. https://doi.org/10.1093/HMG/DDN291
Article CAS PubMed Central Google Scholar
Amann-Zalcenstein D, Avidan N, Kanyas K et al (2006) (2006) AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia. Eur J Hum Genet 1410(14):1111–1119. https://doi.org/10.1038/sj.ejhg.5201675
Barbisan F, Azzolin VF, Teixeira CF, et al (2017) Xanthine-catechin mixture enhances lithium-induced anti-inflammatory response in activated macrophages in vitro. Biomed Res Int 2017. https://doi.org/10.1155/2017/4151594
Brambilla P, Bellani M, Isola M et al (2014) Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia. Transl Psychiatry 4:e406–e406. https://doi.org/10.1038/tp.2014.46
Article CAS PubMed Central Google Scholar
Cade JF (1949) Lithium salts in the treatment of psychotic excitement. Med J Aust 2:349–352. https://doi.org/10.1080/j.1440-1614.1999.06241.x
Carvalho AF, Firth J, Vieta E (2020) Bipolar disorder. N Engl J Med 383:58–66. https://doi.org/10.1056/NEJMRA1906193
Chen CJ, Kono H, Golenbock D et al (2007) Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 13:851–856. https://doi.org/10.1038/NM1603
Chou YH, Hsieh WC, Chen LC et al (2016) Association between the serotonin transporter and cytokines: implications for the pathophysiology of bipolar disorder. J Affect Disord 191:29–35. https://doi.org/10.1016/J.JAD.2015.10.056
Corponi F, Bonassi S, Vieta E et al (2019) Genetic basis of psychopathological dimensions shared between schizophrenia and bipolar disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 89:23–29. https://doi.org/10.1016/J.PNPBP.2018.08.023
de Baumont A, Maschietto M, Lima L et al (2015) Innate immune response is differentially dysregulated between bipolar disease and schizophrenia. Schizophr Res 161:215–221. https://doi.org/10.1016/J.SCHRES.2014.10.055
Di Paolo NC, Shayakhmetov DM (2016) Interleukin 1α and the inflammatory process. Nat Immunol 17:906–913. https://doi.org/10.1038/NI.3503
Article PubMed Central Google Scholar
Dixon-Salazar T, Silhavy JL, Marsh SE et al (2004) Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria. Am J Hum Genet 75:979–987. https://doi.org/10.1086/425985
Article CAS PubMed Central Google Scholar
Dong H, Zhang X, Dai X et al (2014) Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation 11:140. https://doi.org/10.1186/s12974-014-0140-4
Article CAS PubMed Central Google Scholar
Elliott EI, Sutterwala FS (2015) Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev 265:35–52. https://doi.org/10.1111/IMR.12286
Article CAS PubMed Central Google Scholar
Fries GR, Walss-Bass C, Bauer ME, Teixeira AL (2019) Revisiting inflammation in bipolar disorder. Pharmacol Biochem Behav 177:12–19. https://doi.org/10.1016/j.pbb.2018.12.006
Groß O, Yazdi AS, Thomas CJ et al (2012) Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36:388–400. https://doi.org/10.1016/J.IMMUNI.2012.01.018
He Y, Hara H, Núñez G (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 41:1012–1021. https://doi.org/10.1016/J.TIBS.2016.09.002
Article CAS PubMed Central Google Scholar
Himmerich H, Bartsch S, Hamer H et al (2014) Modulation of cytokine production by drugs with antiepileptic or mood stabilizer properties in anti-CD3- and anti-Cd40-stimulated blood in vitro. Oxid Med Cell Longev 2014. https://doi.org/10.1155/2014/806162
Hung Y-Y, Huang K-W, Kang H-Y et al (2016) Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder. Psychopharmacology 233:1707–1714. https://doi.org/10.1007/s00213-015-4087-7
Ingason A, Sigmundsson T, Steinberg S et al (2007) Support for involvement of the AHI1 locus in schizophrenia. Eur J Hum Genet 15:988–991. https://doi.org/10.1038/SJ.EJHG.5201848
Ingason A, Giegling I, Cichon S et al (2010) A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Hum Mol Genet 19:1379–1386. https://doi.org/10.1093/HMG/DDQ009
Article CAS PubMed Central Google Scholar
Jones SA, Jenkins BJ (2018) Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat Rev Immunol 18:773–789
Kanneganti TD (2015) The inflammasome: firing up innate immunity. Immunol Rev 265:1–5. https://doi.org/10.1111/imr.12297
Article CAS PubMed Central Google Scholar
Khan MS, Ali T, Abid MN et al (2017) Lithium ameliorates lipopolysaccharide-induced neurotoxicity in the cortex and hippocampus of the adult rat brain. Neurochem Int 108:343–354. https://doi.org/10.1016/J.NEUINT.2017.05.008
Kim HK, Andreazza AC, Elmi N et al (2016) Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation. J Psychiatr Res 72:43–50 https://doi.org/10.1016/j.jpsychires.2015.10.015
Knijff EM, Nadine BM, Kupka RW et al (2007) An imbalance in the production of IL-1β and IL-6 by monocytes of bipolar patients: restoration by lithium treatment. Bipolar Disord 9:743–753. https://doi.org/10.1111/j.1399-5618.2007.00444.x
Lancaster MA, Gopal DJ, Kim J et al (2011) Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med 17:726–731. https://doi.org/10.1038/nm.2380
Article CAS PubMed Central Google Scholar
Landén M, Larsson H, Lichtenstein P et al (2021) Respiratory infections during lithium and valproate medication: a within-individual prospective study of 50,000 patients with bipolar disorder. Int J Bipolar Disord 9:4. https://doi.org/10.1186/s40345-020-00208-y
Article CAS PubMed Central Google Scholar
Le Clerc S, Lombardi L, Baune BT et al (2021) HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders. Sci Rep 11:70. https://doi.org/10.1038/S41598-021-97140-7
Lesh TA, Careaga M, Rose DR et al (2018) Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms. J Neuroinflammation 15. https://doi.org/10.1186/S12974-018-1197-2
Leu SJ, Yang YY, Liu HC et al (2017) Valproic acid and lithium meditate anti-inflammatory effects by differentially modulating dendritic cell differentiation and function. J Cell Physiol 232:1176–1186. https://doi.org/10.1002/JCP.25604
Li N, Zhang X, Dong H et al (2016) Lithium ameliorates LPS-induced astrocytes activation partly via inhibition of Toll-like receptor 4 expression. Cell Physiol Biochem 38:714–725. https://doi.org/10.1159/000443028
Li HJ, Gao DS, Li YT et al (2018) Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro. Res Vet Sci 118:288–294. https://doi.org/10.1016/J.RVSC.2018.03.002
Article CAS PubMed Central Google Scholar
Lu SM, Gui B, Dong HQ et al (2015) Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain Res Bull 114:31–41. https://doi.org/10.1016/J.BRAINRESBULL.2015.02.008
Mazgaeen L, Gurung P (2020) Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci 21. https://doi.org/10.3390/IJMS21020379
Murru A, Manchia M, Hajek T et al (2020) Lithium’s antiviral effects: a potential drug for COVID-19 disease? Int J Bipolar Disord 8:1–9. https://doi.org/10.1186/S40345-020-00191-4/METRICS
Nassar A, Azab AN (2014) Effects of lithium on inflammation. ACS Chem Neurosci 5:451–458. https://doi.org/10.1021/cn500038f
Article CAS PubMed Central Google Scholar
Nunes A, Trappenberg T, Alda M (2020) Asymmetrical reliability of the Alda score favours a dichotomous representation of lithium responsiveness. PLoS ONE 15:e0225353. https://doi.org/10.1371/JOURNAL.PONE.0225353
Article CAS PubMed Central Google Scholar
Oliveira J, Busson M, Etain B et al (2014) Polymorphism of Toll-like receptor 4 gene in bipolar disorder. J Affect Disord 152–154:395–402. https://doi.org/10.1016/J.JAD.2013.09.043
Comments (0)