Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington

Book  Google Scholar 

Anthony JC, Warner LA, Kessler RC (1994) Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey. Exp Clin Psychopharmacol 2:244–268

Article  Google Scholar 

Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Natt D, Mayfield RD, Adermark L, Heilig M (2018) A molecular mechanism for choosing alcohol over an alternative reward. Science 360:1321–1326

Article  PubMed  CAS  Google Scholar 

Belin D, Balado E, Piazza PV, Deroche-Gamonet V (2009) Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats. Biol Psychiatry 65:863–868

Article  PubMed  CAS  Google Scholar 

Belin-Rauscent A, Fouyssac M, Bonci A, Belin D (2016) How preclinical models evolved to resemble the diagnostic criteria of drug addiction. Biol Psychiatry 79:39–46

Article  PubMed  Google Scholar 

Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A (2013) Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature 496:359–362

Article  PubMed  CAS  Google Scholar 

de Jong JW, Meijboom KE, Vanderschuren LJMJ, Adan RA (2013) Low control over palatable food intake in rats is associated with habitual behavior and relapse vulnerability: individual differences. PLoS ONE 8:e74645

Article  PubMed  PubMed Central  Google Scholar 

Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305:1014–1017

Article  PubMed  CAS  Google Scholar 

Dickinson A, Pearce JM (1976) Preference and response suppression under different correlations between shock and a positive reinforcer in rats. Learn Motiv 7:66–85

Article  Google Scholar 

Goldstein RZ, Craig AD, Bechara A, Garavan H, Childress AR, Paulus MP, Volkow ND (2009) The neurocircuitry of impaired insight in drug addiction. Trends Cogn Sci 13:372–380

Article  PubMed  PubMed Central  Google Scholar 

Goltseker K, Hopf FW, Barak S (2018) Advances in behavioral animal models of alcohol use disorder. Alcohol 74:73–82

Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A (2010) Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res 34:1565–1573

Hopf FW, Lesscher HMB (2014) Rodent models for compulsive alcohol intake. Alcohol 48:253–264

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kearns DN, Weiss SJ, Panlilio LV (2002) Conditioned suppression of behavior maintained by cocaine self-administration. Drug Alcohol Depend 65:253–261

Article  PubMed  CAS  Google Scholar 

Lesscher HMB, van Kerkhof LW, Vanderschuren LJMJ (2010) Inflexible and indifferent alcohol drinking in male mice. Alcohol Clin Exp Res 34:1219–1225

Article  PubMed  CAS  Google Scholar 

Limpens JH, Schut EH, Voorn P, Vanderschuren LJ (2014a) Using conditioned suppression to investigate compulsive drug seeking in rats. Drug Alcohol Depend 142:314–324

Article  PubMed  Google Scholar 

Limpens JHW, Damsteegt R, Broekhoven MH, Vanderschuren LJMJ (2014b) Pharmacological inactivation of the prelimbic cortex emulates compulsive cocaine seeking in rats. Brain Res 1628:210–218

Article  PubMed  Google Scholar 

Miles FJ, Everitt BJ, Dickinson A (2003) Oral cocaine seeking by rats: action or habit?. Behav Neurosci 5:927–938

O’Brien CP (2008) Review. Evidence-based treatments of addiction. Philos Trans R Soc Lond B Biol Sci 363:3277–3286

Article  PubMed  PubMed Central  Google Scholar 

Pelloux Y, Everitt BJ, Dickinson A (2007) Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology 194:127–137

Article  PubMed  CAS  Google Scholar 

Robbins TW, Costa RM (2017) Habits. Curr Biol 27:R1200–R1206

Article  PubMed  CAS  Google Scholar 

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW (2013) Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci 16:1094–1100

Article  PubMed  PubMed Central  CAS  Google Scholar 

Spanagel R (2017) Animal models of addiction. Dialogues Clin Neurosci 19:247–258

Article  PubMed  PubMed Central  Google Scholar 

Spoelder M, Hesseling P, Baars AM, Lozeman-van ’t Klooster JG, Rotte MD, Vanderschuren LJMJ, Lesscher HMB (2015) Individual variation in alcohol intake predicts reinforcement, motivation, and compulsive alcohol use in rats. Alcohol Clin Exp Res 39:2427–37

Article  PubMed  CAS  Google Scholar 

Spoelder M, Pol S, Janssen BSG, Baars AM, Vanderschuren LJMJ, Lesscher HMB (2017) Loss of control over alcohol seeking in rats depends on individual vulnerability and duration of alcohol consumption experience. Behav Pharmacol 28:334–344

Article  PubMed  CAS  Google Scholar 

Uhl GR, Grow RW (2004) The burden of complex genetics in brain disorders. Arch Gen Psychiatry 61:223–229

Article  PubMed  Google Scholar 

UNODC (2022) World drug report

van den Brink W (2012) Evidence-based pharmacological treatment of substance use disorders and pathological gambling. Curr Drug Abuse Rev 5:3–31

Article  PubMed  Google Scholar 

Vanderschuren LJ, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305:1017–1019

Article  PubMed  CAS  Google Scholar 

Vanderschuren LJMJ, Minnaard AM, Smeets JAS, Lesscher HMB (2017) Punishment models of addictive behavior. Curr Opin Behav Sci 13:77–84

Article  Google Scholar 

Vanderschuren LJMJ, Ahmed SH (2021) Animal models of the behavioral symptoms of substance use disorders. Cold Spring Harb Perspect Med 11:a040287