Agoglia AE, Holstein SE, Small AT, Spanos M, Burrus BM, Hodge CW (2017) Comparison of the adolescent and adult mouse prefrontal cortex proteome. PLoS One 12:e0178391. https://doi.org/10.1371/journal.pone.0178391
Article CAS PubMed PubMed Central Google Scholar
Bissen D, Foss F, Acker-Palmer A (2019) AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking. Cell Mol Life Sci 76:2133–2169. https://doi.org/10.1007/s00018-019-03068-7
Article CAS PubMed PubMed Central Google Scholar
Camp MC, Feyder M, Ihne J, Palachick B, Hurd B, Karlsson RM, Noronha B, Chen YC, Coba MP, Grant SG, Holmes A (2011) A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference. Addict Biol 16:428–39. https://doi.org/10.1111/j.1369-1600.2010.00282.x
Article CAS PubMed Google Scholar
Cannady R, Fisher KR, Durant B, Besheer J, Hodge CW (2013) Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement. Addict Biol 18:54–65. https://doi.org/10.1111/adb.12000
Article CAS PubMed Google Scholar
Cannady R, Fisher KR, Graham C, Crayle J, Besheer J, Hodge CW (2017) Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner. Addict Biol 22:652–664. https://doi.org/10.1111/adb.12357
Article CAS PubMed Google Scholar
Crabbe JC, Harris RA, Koob GF (2011) Preclinical studies of alcohol binge drinking. Ann N Y Acad Sci 1216:24–40. https://doi.org/10.1111/j.1749-6632.2010.05895.x
Article CAS PubMed PubMed Central Google Scholar
Faccidomo S, Besheer J, Stanford PC, Hodge CW (2009a) Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology (Berl) 204:135–47. https://doi.org/10.1007/s00213-008-1444-9
Article CAS PubMed Google Scholar
Faccidomo S, Besheer J, Stanford PC, Hodge CW (2009b) Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK 1/2, but not JNK, MAP kinase pathway. Psychopharmacology 204:135–147. https://doi.org/10.1007/s00213-008-1444-9
Article CAS PubMed PubMed Central Google Scholar
Faccidomo S, Salling MC, Galunas C, Hodge CW (2015) Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice. Psychopharmacology (Berl) 232:3417–30. https://doi.org/10.1007/s00213-015-3993-z
Article CAS PubMed Google Scholar
Faccidomo S, Swaim KS, Saunders BL, Santanam TS, Taylor SM, Kim M, Reid GT, Eastman VR, Hodge CW (2018) Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice. Psychopharmacology (Berl) 235:1681–1696. https://doi.org/10.1007/s00213-018-4870-3
Article CAS PubMed Google Scholar
Faccidomo S, Holstein SE, Santanam TS, Saunders BL, Swaim KS, Reid GT, O’Neill C, Eastman VR, Hodge CW (2020) Pharmacological inhibition of glycogen synthase kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3beta, protein interacting with C kinase and GluA2 protein expression in the reward pathway of male C57BL/6J mice. Behav Pharmacol 31:15–26. https://doi.org/10.1097/FBP.0000000000000501
Article CAS PubMed PubMed Central Google Scholar
Faccidomo S, Cogan ES, Hon OJ, Hoffman JL, Saunders BL, Eastman VR, Kim M, Taylor SM, McElligott ZA, Hodge CW (2021) Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration. Addict Biol 26:e13049. https://doi.org/10.1111/adb.13049
Article CAS PubMed Google Scholar
Faccidomo S, Eastman VR, Santanam TS, Swaim KS, Taylor SM, Hodge CW (2025) Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity. Front Behav Neurosci 18:1498201. https://doi.org/10.3389/fnbeh.2024.1498201
Article PubMed PubMed Central Google Scholar
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW (2024) Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug. Psychopharmacology (Berl). https://doi.org/10.1007/s00213-024-06740-4
Hodge CW, Samson HH, Haraguchi M (1992) Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding. Pharmacol Biochem Behav 43:249–54. https://doi.org/10.1016/0091-3057(92)90665-3
Article CAS PubMed Google Scholar
Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO (1999) Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. Nat Neurosci 2:997–1002. https://doi.org/10.1038/14795
Article CAS PubMed Google Scholar
Hodge CW, Raber J, McMahon T, Walter H, Sanchez-Perez AM, Olive MF, Mehmert K, Morrow AL, Messing RO (2002) Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cε. J Clin Investig 110:1003–1010
CAS PubMed PubMed Central Google Scholar
Hodge CW, Kelley SP, Bratt AM, Iller K, Schroeder JP, Besheer J (2004) 5-HT(3A) receptor subunit is required for 5-HT3 antagonist-induced reductions in alcohol drinking. Neuropsychopharmacology 29:1807–13. https://doi.org/10.1038/sj.npp.1300498
Article CAS PubMed Google Scholar
Hodge CW, Miles MF, Sharko AC, Stevenson RA, Hillmann JR, Lepoutre V, Besheer J, Schroeder JP (2006) The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology (Berl) 183:429–38. https://doi.org/10.1007/s00213-005-0217-y
Article CAS PubMed Google Scholar
Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW (2019) Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer’s disease. Int Rev Neurobiol 148:169–230. https://doi.org/10.1016/bs.irn.2019.10.017
Article PubMed PubMed Central Google Scholar
Hoffman JL, Faccidomo S, Saunders BL, Taylor SM, Kim M, Hodge CW (2021) Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein gamma-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res 45:1424–1435. https://doi.org/10.1111/acer.14639
Article CAS PubMed PubMed Central Google Scholar
Hoffman JL, Faccidomo SP, Taylor SM, DeMiceli KG, May AM, Smith EN, Whindleton CM, Hodge CW (2023) Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein gamma-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice. Psychopharmacology (Berl) 240:1261–1273. https://doi.org/10.1007/s00213-023-06365-z
Article CAS PubMed Google Scholar
Holmes A, Spanagel R, Krystal JH (2013) Glutamatergic targets for new alcohol medications. Psychopharmacology (Berl) 229:539–54. https://doi.org/10.1007/s00213-013-3226-2
Article CAS PubMed Google Scholar
Hopf FW, Mangieri RA (2018) Do alcohol-related AMPA-type glutamate receptor adaptations promote intake?. In: Grant K. LD (ed) The neuropharmacology of alcohol Handb Exp Pharmacol Springer, Cham, pp 157–186. https://doi.org/10.1007/164_2018_105
Hyman SE (2005) Addiction: a disease of learning and memory. Am J Psychiatry 162:1414–22. https://doi.org/10.1176/appi.ajp.162.8.1414
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565–98. https://doi.org/10.1146/annurev.neuro.29.051605.113009
Article CAS PubMed Google Scholar
Jackson AC, Nicoll RA (2011) The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits. Neuron 70:178–99. https://doi.org/10.1016/j.neuron.2011.04.007
Article CAS PubMed PubMed Central Google Scholar
Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS (2010a) Hippocampal AMPA receptor gating controlled by both TARP an
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