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Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways
Multiple pathogenic processes contribute to cerebral ischemia–reperfusion injury (CIRI); however, their relative imp...
Resveratrol's Multifaceted Potential in Alzheimer’s Disease: Insights from Preclinical and Clinical Evidence
Resveratrol's Multifaceted Potential in Alzheimer’s Disease: Insights from Preclinical and Clinical Evidence
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques...
Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus
Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus
The signal transduction and communication between adipose tissue–secreted adipokines and the central nervous system ...
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit hyperactivity disorders, schiz...
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism ...
Knock-out of Tpm4.2/Actin Filaments Alters Neuronal Signaling, Neurite Outgrowth, and Behavioral Phenotypes in Mice
Knock-out of Tpm4.2/Actin Filaments Alters Neuronal Signaling, Neurite Outgrowth, and Behavioral Phenotypes in Mice
Tropomyosins (Tpm) are master regulators of actin dynamics through forming co-polymers with filamentous actin. Despite the...
Using Blood-Based Biomarkers to Facilitate the Diagnosis of Alzheimer’s Disease: Insights from a Novel Pyroptosis-Associated Molecular Signature Model
Using Blood-Based Biomarkers to Facilitate the Diagnosis of Alzheimer’s Disease: Insights from a Novel Pyroptosis-Associated Molecular Signature Model
Alzheimer’s disease (AD) stands as the primary reason for aging-related dementia and is swiftly becoming recognized ...
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerat...
Investigating Hippocampal Lateralization: Effects of Nickel on Neurobiological, AchE Activity, and Neurobehavioral Changes in the Wistar Rats
Investigating Hippocampal Lateralization: Effects of Nickel on Neurobiological, AchE Activity, and Neurobehavioral Changes in the Wistar Rats
Nickel (Ni) is a heavy metal that is widely distributed in the environment and has harmful effects on human health, especi...
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Urtica dioica L. (U. dioica; Family Urticaceae) has been utilized since ancient times, both as a nutritional source and fo...
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
Komagataella pastoris is a promising probiotic for modulating the microbiota-gut-brain axis, and growing evidence has demo...
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
ZJQ-3F regulates synaptic dysfunction in the cortex and hippocampus of APP/PS1/Tau transgenic mice. (A) The expression of ...
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastr...
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Alzheimer’s disease (AD), which is known for causing cognitive decline and significant synaptic dysfunction, continu...
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
The microtubule-associated protein tau plays a central role in neurodegenerative diseases, called tauopathies, but the mec...
Mendelian Randomization in Conjunction with WGCNA Was Employed to Investigate the Potential Role of the Liver-Brain Axis in the Pathogenesis of Hepatocellular Carcinoma and Alzheimer’s Disease
Mendelian Randomization in Conjunction with WGCNA Was Employed to Investigate the Potential Role of the Liver-Brain Axis in the Pathogenesis of Hepatocellular Carcinoma and Alzheimer’s Disease
Alzheimer’s disease (AD) and hepatocellular carcinoma (HCC) are prevalent age-related diseases. While the gut-liver-...
Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Depression is a common psychological disease with high morbidity and mortality. Recently, the involvement of synaptic plas...
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Cannabis is an annual herb of the genus Cannabis, with a history of medical use going back thousands of years. However, it...
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since ...
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
The most prevalent form of dementia, Alzheimer’s disease (AD) is a chronic illness that is on the rise among the ger...
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resultin...
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Wilson disease, a rare genetic disorder resulting from mutations in the ATP7B gene disrupts copper metabolism, leading to ...
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Targeting the non-nuclear estrogen receptor (ER) signaling has been postulated as novel therapeutic strategy for central n...
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonom...
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
The aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood br...
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Intestinal microfold cells (M cells) play a critical role in the immune response of the intestinal mucosa by actively taki...
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Iron is widely linked with the onset and development of Parkinson’s disease (PD). Accumulation of iron induces free ...
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide...
CircTrim37 Ameliorates Intracerebral Hemorrhage Outcomes by Modulating Microglial Polarization via the miR-30c-5p/SOCS3 Axis
CircTrim37 Ameliorates Intracerebral Hemorrhage Outcomes by Modulating Microglial Polarization via the miR-30c-5p/SOCS3 Axis
Circular RNAs (circRNAs) have been progressively recognized as critical regulators in the pathology and pathophysiology of...
A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis
A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis
Radiotherapy for head and neck tumors can lead to a severe complication known as radiation-induced brain injury (RIBI). Ho...
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