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Gut Microbiota and Mitochondrial Dysfunction in Autism: Clinical Correlations and Future Directions
Gut Microbiota and Mitochondrial Dysfunction in Autism: Clinical Correlations and Future Directions
Autism spectrum disorder (ASD) is a multifactorial, neuro-psychiatric, and neurodevelopmental illness possessing impaired ...
Exploring Green-Synthesized Silver Nanoparticles in Neurodegeneration: a Systematic Review of Cholinesterase Enzyme Interactions
Exploring Green-Synthesized Silver Nanoparticles in Neurodegeneration: a Systematic Review of Cholinesterase Enzyme Interactions
Neurodegenerative disorders, particularly Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington&#...
Redox Perturbation in Cadmium-Mediated Hypothalamic, Pituitary, and Testicular Impairment and Protective Effects of Zinc in Rats Is Accompanied by Modulation of Tryptophan Catabolism Enzyme/Protein
Redox Perturbation in Cadmium-Mediated Hypothalamic, Pituitary, and Testicular Impairment and Protective Effects of Zinc in Rats Is Accompanied by Modulation of Tryptophan Catabolism Enzyme/Protein
Cadmium (Cd) is a toxic heavy metal found in the environment from natural (volcanic eruptions) and industrial sources, inc...
Plumbagin Ameliorate 5-Fluorouracil-Induced Cognitive Impairment in Adult Zebrafish: and Evidences
Plumbagin Ameliorate 5-Fluorouracil-Induced Cognitive Impairment in Adult Zebrafish: and Evidences
Chemotherapy is a crucial part of cancer treatment, but it has been linked to a set of cognitive impairments. 5-Fluorourac...
Lipid Metabolic Mediators Bridge Ischemic Heart Disease and Amyotrophic Lateral Sclerosis
Lipid Metabolic Mediators Bridge Ischemic Heart Disease and Amyotrophic Lateral Sclerosis
While epidemiological studies have linked cardiovascular disease (CVD) and amyotrophic lateral sclerosis (ALS), the causal...
Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits
Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits
The long-term effects of non-convulsive status epilepticus (NCSE) and their mechanisms in the brain remain largely unknown...
Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer’s Disease: Insights from a Diverse Latin American Cohort
Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer’s Disease: Insights from a Diverse Latin American Cohort
Alzheimer’s disease (AD) is characterized by an insidious onset and complex pathophysiology, necessitating the devel...
Mechanistic Investigation of TSPO-Mediated Dysregulation of Mitochondrial Copper Homeostasis in Microglia and its Role in Perioperative Neurocognitive Disorders
Mechanistic Investigation of TSPO-Mediated Dysregulation of Mitochondrial Copper Homeostasis in Microglia and its Role in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorders (PND) are common complications in elderly surgical patients; their mechanisms remai...
In Vitro Analysis of TWEAK/Fn14 Axis in the Blood–Brain Barrier Models during Oxygen–Glucose Deprivation and Reoxygenation
In Vitro Analysis of TWEAK/Fn14 Axis in the Blood–Brain Barrier Models during Oxygen–Glucose Deprivation and Reoxygenation
Upregulation of tumor necrosis factor-like weak apoptosis-inducing factor (TWEAK) and its receptor fibroblast growth facto...
Gastrodin Ameliorates Pain-Depression Comorbidity through SIRT3-Dependent Alleviation of Oxidative Stress and Promotion of Mitochondrial Biogenesis
Gastrodin Ameliorates Pain-Depression Comorbidity through SIRT3-Dependent Alleviation of Oxidative Stress and Promotion of Mitochondrial Biogenesis
Neuropathic pain (NP) and depression frequently co-occur, creating a complex clinical challenge with limited therapeutic o...
P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke
P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke
Secondary damage in remote brain regions following ischemic stroke significantly worsens patient outcomes, yet its underly...
Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflammation and Disease Activity in Multiple Sclerosis
Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflammation and Disease Activity in Multiple Sclerosis
Serum miRNA-155 and TREM2 levels were investigated as potential non-invasive indicators. In this case–control study,...
Synergistic Efficacy of Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway
Synergistic Efficacy of Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway
Mesenchymal stem cells (MSCs)–based therapy has received considerable research attention for its anti-inflammatory p...
Offers Vagus-Dependent Neuroprotection Against Parkinson’s Disease
Offers Vagus-Dependent Neuroprotection Against Parkinson’s Disease
Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration and increasingly associated with gut mic...
Up-regulated miR-4443 Holds Diagnostic Significance for Parkinson’s Disease and may be Involved in Neuroinflammation
Up-regulated miR-4443 Holds Diagnostic Significance for Parkinson’s Disease and may be Involved in Neuroinflammation
Parkinson’s disease (PD) is a widespread neurodegenerative disorder. MicroRNAs (miRNAs) have emerged as crucial regu...
VKORC1L1 Downregulation Induced Vitamin K Cycle Disorder Exacerbates Neuronal Ferroptosis After Spinal Cord Injury
VKORC1L1 Downregulation Induced Vitamin K Cycle Disorder Exacerbates Neuronal Ferroptosis After Spinal Cord Injury
Ferroptosis contributes significantly to neuronal loss and functional decline after spinal cord injury (SCI). Emerging evi...
Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review
Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review
Spinal cord injuries (SCI) are associated with significant physical and economic burdens on individuals and healthcare sys...
4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory
4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory
mRNA translational repression by eukaryotic initiation factor 4E-binding proteins (4E-BPs), plays a critical role in synap...
Ptbp2 Alleviates Neuroinflammation and Blood–brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke
Ptbp2 Alleviates Neuroinflammation and Blood–brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke
Damage following ischemic stroke is worsened by microglial activation and subsequent neuroinflammation. Polypyrimidine tra...
Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects
Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects
Gulf War Illness (GWI) is a chronic, multi-system condition affecting a substantial proportion of veterans deployed during...
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways
Multiple pathogenic processes contribute to cerebral ischemia–reperfusion injury (CIRI); however, their relative imp...
Resveratrol's Multifaceted Potential in Alzheimer’s Disease: Insights from Preclinical and Clinical Evidence
Resveratrol's Multifaceted Potential in Alzheimer’s Disease: Insights from Preclinical and Clinical Evidence
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques...
Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus
Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus
The signal transduction and communication between adipose tissue–secreted adipokines and the central nervous system ...
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit hyperactivity disorders, schiz...
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism ...
Knock-out of Tpm4.2/Actin Filaments Alters Neuronal Signaling, Neurite Outgrowth, and Behavioral Phenotypes in Mice
Knock-out of Tpm4.2/Actin Filaments Alters Neuronal Signaling, Neurite Outgrowth, and Behavioral Phenotypes in Mice
Tropomyosins (Tpm) are master regulators of actin dynamics through forming co-polymers with filamentous actin. Despite the...
Using Blood-Based Biomarkers to Facilitate the Diagnosis of Alzheimer’s Disease: Insights from a Novel Pyroptosis-Associated Molecular Signature Model
Using Blood-Based Biomarkers to Facilitate the Diagnosis of Alzheimer’s Disease: Insights from a Novel Pyroptosis-Associated Molecular Signature Model
Alzheimer’s disease (AD) stands as the primary reason for aging-related dementia and is swiftly becoming recognized ...
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerat...
Investigating Hippocampal Lateralization: Effects of Nickel on Neurobiological, AchE Activity, and Neurobehavioral Changes in the Wistar Rats
Investigating Hippocampal Lateralization: Effects of Nickel on Neurobiological, AchE Activity, and Neurobehavioral Changes in the Wistar Rats
Nickel (Ni) is a heavy metal that is widely distributed in the environment and has harmful effects on human health, especi...
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Urtica dioica L. (U. dioica; Family Urticaceae) has been utilized since ancient times, both as a nutritional source and fo...
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