Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus

Engin A (2017) The definition and prevalence of obesity and metabolic syndrome. Adv Exp Med Biol 960:1–17. https://doi.org/10.1007/978-3-319-48382-5_1

Article  CAS  PubMed  Google Scholar 

Obesity and overweight. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 21 Jul 2024

Neto A, Fernandes A, Barateiro A (2023) The complex relationship between obesity and neurodegenerative diseases: an updated review. Front Cell Neurosci 17:1294420. https://doi.org/10.3389/fncel.2023.1294420

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dementia. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/dementia. Accessed 21 Jul 2024

Tobeh NS, Bruce KD (2023) Emerging Alzheimer’s disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions. Front Aging Neurosci 15:1259012. https://doi.org/10.3389/fnagi.2023.1259012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R-Y et al (2022) TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Mol Neurodegener 17(1):40. https://doi.org/10.1186/s13024-022-00542-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu TM, Kanoski SE (2014) Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Front Aging Neurosci 6:88. https://doi.org/10.3389/fnagi.2014.00088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soczynska JK et al (2011) Mood disorders and obesity: understanding inflammation as a pathophysiological nexus. Neuromolecular Med 13(2):93–116. https://doi.org/10.1007/s12017-010-8140-8

Article  CAS  PubMed  Google Scholar 

Kim JY, Barua S, Jeong YJ, Lee JE (2020) Adiponectin: the potential regulator and therapeutic target of obesity and Alzheimer’s disease. Int J Mol Sci. https://doi.org/10.3390/ijms21176419

Article  PubMed  PubMed Central  Google Scholar 

Bettinetti-Luque M et al (2024) Adipose tissue as a therapeutic target for vascular damage in Alzheimer’s disease. Br J Pharmacol 181(6):840–878. https://doi.org/10.1111/bph.16243

Article  CAS  PubMed  Google Scholar 

Bender AC, Austin AM, Grodstein F, Bynum JPW (2017) Executive function, episodic memory, and Medicare expenditures. Alzheimers Dement 13(7):792–800. https://doi.org/10.1016/j.jalz.2016.12.013

Article  PubMed  Google Scholar 

Costache AD et al (2023) Inflammatory pathways in overweight and obese persons as a potential mechanism for cognitive impairment and earlier onset Alzeihmer’s dementia in the general population: a narrative review. Biomedicines. https://doi.org/10.3390/biomedicines11123233

Article  PubMed  PubMed Central  Google Scholar 

Diamond A (2013) Executive functions. Annu Rev Psychol 64:135–168. https://doi.org/10.1146/annurev-psych-113011-143750

Article  PubMed  Google Scholar 

Cristofori I, Cohen-Zimerman S, Grafman J (2019) Executive functions. Handb Clin Neurol 163:197–219. https://doi.org/10.1016/B978-0-12-804281-6.00011-2

Article  PubMed  Google Scholar 

Dias BF, Rezende LO, Malloy-Diniz LF, de Paula JJ (2018) Relationship between visuospatial episodic memory, processing speed and executive function: are they stable over a lifespan? Arq Neuropsiquiatr 76(2):89–92. https://doi.org/10.1590/0004-282X20170186

Article  PubMed  Google Scholar 

Friedman NP, Robbins TW (2022) The role of prefrontal cortex in cognitive control and executive function. Neuropsychopharmacology 47(1):72–89. https://doi.org/10.1038/s41386-021-01132-0

Article  PubMed  Google Scholar 

Abellán-Martínez M, Castellanos López MÁ, Delgado-Losada ML, Yubero R, Paúl N, Unturbe FM (2019) Executive control on memory test performance across life: test of memory strategies. Span J Psychol 22:E50. https://doi.org/10.1017/sjp.2019.47

Article  PubMed  Google Scholar 

Cui Y, Tang T-Y, Lu C-Q, Ju S (2022) Insulin resistance and cognitive impairment: evidence from neuroimaging. J Magn Reson Imaging 56(6):1621–1649. https://doi.org/10.1002/jmri.28358

Article  PubMed  Google Scholar 

Scaduto P et al (2023) Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change. Acta Neuropathol 145(3):303–324. https://doi.org/10.1007/s00401-022-02526-0

Article  PubMed  Google Scholar 

Kim DW, Glendining KA, Grattan DR, Jasoni CL (2016) Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology 157(6):2229–2242. https://doi.org/10.1210/en.2016-1014

Article  CAS  PubMed  Google Scholar 

Banks WA, Farr SA, Morley JE (2006) The effects of high fat diets on the blood-brain barrier transport of leptin: failure or adaptation? Physiol Behav 88(3):244–248. https://doi.org/10.1016/j.physbeh.2006.05.037

Article  CAS  PubMed  Google Scholar 

Duquenne M et al (2021) Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function. Nat Metab 3:1071–1090. https://doi.org/10.1038/s42255-021-00432-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martelli D, Brooks VL (2023) Leptin increases: physiological roles in the control of sympathetic nerve activity, energy balance, and the hypothalamic-pituitary-thyroid axis. Int J Mol Sci. vol 24, no 3, https://doi.org/10.3390/ijms24032684

Prickett C, Brennan L, Stolwyk R (2015) Examining the relationship between obesity and cognitive function: a systematic literature review. Obes Res Clin Pract 9(2):93–113. https://doi.org/10.1016/j.orcp.2014.05.001

Article  PubMed  Google Scholar 

Miller AL, Lee HJ, Lumeng JC (2015) Obesity-associated biomarkers and executive function in children. Pediatr Res 77:143–147. https://doi.org/10.1038/pr.2014.158

Article  PubMed  Google Scholar 

Smith E, Hay P, Campbell L, Trollor JN (2011) A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment. Obes Rev 12(9):740–755. https://doi.org/10.1111/j.1467-789X.2011.00920.x

Article  CAS  PubMed  Google Scholar 

Nguyen JCD, Killcross AS, Jenkins TA (2014) Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci 8:375. https://doi.org/10.3389/fnins.2014.00375

Article  PubMed  PubMed Central  Google Scholar 

Hawkins MAW et al (2021) Baseline associations between biomarkers, cognitive function, and self-regulation indices in the Cognitive and Self-regulatory Mechanisms of Obesity Study. Obes Sci Pract 7(6):669–681. https://doi.org/10.1002/osp4.537

Article  PubMed  PubMed Central  Google Scholar 

Holden KF, Lindquist K, Tylavsky FA, Rosano C, Harris TB, Yaffe K (2009) Serum leptin level and cognition in the elderly: findings from the health ABC study. Neurobiol Aging 30:1483–1489. https://doi.org/10.1016/j.neurobiolaging.2007.11.024

Article  CAS  PubMed  Google Scholar 

Tucsek Z et al (2014) Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer’s disease. J Gerontol A Biol Sci Med Sci 69(10):1212–1226. https://doi.org/10.1093/gerona/glt177

Article  CAS  PubMed  Google Scholar 

Macaluso F et al (2022) Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection. J Clin Endocrinol Metab 107(3):e1126–e1135. https://doi.org/10.1210/clinem/dgab759

Article  PubMed 

Comments (0)

No login
gif