Liu Q, Li R, Yang W et al (2021) Role of neuroglia in neuropathic pain and depression. Pharmacol Res 174:105957–105957. https://doi.org/10.1016/j.phrs.2021.105957

Article  CAS  Google Scholar 

Cohen SP, Vase L, Hooten WM (2021) Chronic pain: an update on burden, best practices, and new advances. Lancet 397(10289):2082–2097. https://doi.org/10.1016/S0140-6736(21)00393-7

Article  PubMed  Google Scholar 

Meda RT, Nuguru SP, Rachakonda S et al (2022) Chronic pain-induced depression: a review of prevalence and management. Cureus 14(8):e28416. https://doi.org/10.7759/cureus.28416

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Liu S, Zhu X et al (2019) Hippocampal PKR/NLRP1 inflammasome pathway is required for the depression-like behaviors in rats with neuropathic pain. Neuroscience 412:16–28. https://doi.org/10.1016/j.neuroscience.2019.05.025

Article  CAS  PubMed  Google Scholar 

Dellarole A, Morton P, Brambilla R et al (2014) Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. Brain Behav Immun 41:65–81. https://doi.org/10.1016/j.bbi.2014.04.003

Article  CAS  PubMed  Google Scholar 

Li DY, Liu L, Liu DQ, Zhang LQ, Zhou YQ, Mei W (2025) Mitochondrial calcium overload contributes to mechanical allodynia in neuropathic pain via inducing mitochondrial dynamic imbalance. Int Immunopharmacol 158:114863. https://doi.org/10.1016/j.intimp.2025.114863

Article  CAS  PubMed  Google Scholar 

Shen J, Xie P, Wang J et al (2024) Nlrp6 protects from corticosterone-induced NSPC ferroptosis by modulating RIG-1/MAVS-mediated mitophagy. Redox Biol 73:103196. https://doi.org/10.1016/j.redox.2024.103196

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abad C, Pinal-Fernandez I, Guillou C et al (2024) IFNγ causes mitochondrial dysfunction and oxidative stress in myositis. Nat Commun 15(1):5403. https://doi.org/10.1038/s41467-024-49460-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verma A, Azhar G, Zhang X et al (2023) P. gingivalis -LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci. https://doi.org/10.3390/ijms24020950

Article  PubMed  PubMed Central  Google Scholar 

Khanna A, Acharjee P et al (2019) Mitochondrial SIRT3 and neurodegenerative brain disorders. J Chem Neuroanat 95:43–53. https://doi.org/10.1016/j.jchemneu.2017.11.009

Park JH, Burgess JD, Faroqi AH et al (2020) Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway. Mol Neurodegener 15(1):5. https://doi.org/10.1186/s13024-019-0349-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui C, Liu M-H, Mou J et al (2023) Identification of hub genes in neuropathic pain-induced depression. Curr Bioinform 18(10):817–829. https://doi.org/10.2174/1574893618666230614093416

Article  CAS  Google Scholar 

Xiao G, Tang R, Yang N et al (2023) Review on pharmacological effects of gastrodin. Arch Pharm Res 46(9–10):744–770. https://doi.org/10.1007/s12272-023-01463-0

Article  CAS  PubMed  Google Scholar 

Wang X, Zhang B, Li X et al (2021) Mechanisms underlying gastrodin alleviating vincristine-induced peripheral neuropathic pain. Front Pharmacol 12:744663. https://doi.org/10.3389/fphar.2021.744663

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Qin S, Yang Z et al (2024) Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice. Behav Brain Res 465:114968. https://doi.org/10.1016/j.bbr.2024.114968

Article  CAS  PubMed  Google Scholar 

Zuo HJ, Wang PX, Ren XQ et al (2024) Gastrodin regulates PI3K/AKT-Sirt3 signaling pathway and proinflammatory mediators in activated microglia. Mol Neurobiol 61(5):2728–2744. https://doi.org/10.1007/s12035-023-03743-8

Article  CAS  PubMed  Google Scholar 

Guo J, Zhang XL, Bao ZR et al (2021) Gastrodin regulates the Notch signaling pathway and Sirt3 in activated microglia in cerebral hypoxic-ischemia neonatal rats and in activated BV-2 microglia. Neuromol Med 23(3):348–362. https://doi.org/10.1007/s12017-020-08627-x

Article  CAS  Google Scholar 

Tenorio G, Kulkarni A, Kerr BJ (2012) Resident glial cell activation in response to perispinal inflammation leads to acute changes in nociceptive sensitivity: implications for the generation of neuropathic pain. Pain 154(1):71–81. https://doi.org/10.1016/j.pain.2012.09.008

Article  PubMed  Google Scholar 

Li L, Zou Y, Liu B et al (2022) Correction to “Contribution of the P2X4 receptor in rat hippocampus to the comorbidity of chronic pain and depression.” ACS Chem Neurosci 13(15):2348–2348. https://doi.org/10.1021/acschemneuro.2c00360

Article  CAS  PubMed  Google Scholar 

Zhang H, Weng J, Sun S et al (2022) Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3. Toxicol Appl Pharmacol 452:116179. https://doi.org/10.1016/j.taap.2022.116179

Article  CAS  PubMed  Google Scholar 

Yang R, Shi L, Si H et al (2023) Gallic acid improves comorbid chronic pain and depression behaviors by inhibiting P2X7 receptor-mediated ferroptosis in the spinal cord of rats. ACS Chem Neurosci 14(4):667–676. https://doi.org/10.1021/acschemneuro.2c00532

Article  CAS  PubMed  Google Scholar 

Guo X, Zhao Y, Huang F et al (2020) Effects of transcutaneous auricular vagus nerve stimulation on peripheral and central tumor necrosis factor alpha in rats with depression-chronic somatic pain comorbidity. Neural Plast 2020:1–10. https://doi.org/10.1155/2020/8885729

Article  CAS  Google Scholar 

Saito T, Chen T, Yatsugi H et al (2022) Independent and combined associations of depressive symptoms and sleep disturbance with chronic pain in community-dwelling older adults. PAIN Rep 7(5):e1034. https://doi.org/10.1097/PR9.0000000000001034

Article  PubMed  PubMed Central  Google Scholar 

Marcuzzi A, Skarpsno ES, Nilsen TIL et al (2022) The interplay between multisite pain and insomnia on the risk of anxiety and depression: the HUNT study. BMC psychiatry 22(1):0–0. https://doi.org/10.1186/s12888-022-03762-0

Amanda E, David B (2013) Neuroinflammation and the generation of neuropathic pain. Br J Anaesth 111(1):26–37. https://doi.org/10.1093/bja/aet128

Article  CAS  Google Scholar 

Xuefeng Yu, Ying Hu, Huang W et al (2019) Role of AMPK/SIRT1-SIRT3 signaling pathway in affective disorders in unpredictable chronic mild stress mice. Neuropharmacology 165:107925–107925. https://doi.org/10.1016/j.neuropharm.2019.107925

Article  CAS  Google Scholar 

Qiujing F (2022) Gastrodin attenuates lipopolysaccharide-induced inflammation and oxidative stress, and promotes the osteogenic differentiation of human periodontal ligament stem cells through enhancing sirtuin3 expression. Exp Ther Med 23(4):0–0. https://doi.org/10.3892/etm.2022.11225

Article  CAS  Google Scholar 

Chen Y, Yang H, Wang D-S et al (2024) Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia. Phytomedicine 128:155369–155369. https://doi.org/10.1016/j.phymed.2024.155369

Article  CAS  Google Scholar 

Phan TT, Jayathilake NJ, Lee KP et al (2023) BDNF/TrkB signaling inhibition suppresses astrogliosis and alleviates mechanical allodynia in a partial crush injury model. Exp Neurobiol 32(5):343–353. https://doi.org/10.5607/en23031

Article  PubMed  PubMed Central  Google Scholar 

da Silva MD, Guginski G, Sato KL, Sanada LS, Sluka KA, Santos AR (2020)  Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells. Brain Behav Immun-Health 7:100118. https://doi.org/10.1016/j.bbih.2020.100118

Zhiqiang Lu, Siqi S, Songyi L (2024) The neuroprotective effects of SFGDI on sirtuin 3-related oxidative stress by regulating the Sirt3/SOD/ROS pathway and energy metabolism in BV2 cells. Food Funct 15(12):6692–6704. https://doi.org/10.1039/d4fo01512f

Article  CAS