Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review

Te Ao B, Brown P, Tobias M, Ameratunga S, Barker-Collo S, Theadom A et al (2014) Cost of traumatic brain injury in New Zealand: evidence from a population-based study. Neurology 83(18):1645–1652

Article  Google Scholar 

James SL, Theadom A, Ellenbogen RG, Bannick MS, Montjoy-Venning W, Lucchesi LR et al (2019) Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 18(1):56–87

Article  Google Scholar 

Ding W, Hu S, Wang P, Kang H, Peng R, Dong Y et al (2022) Spinal cord injury: the global incidence, prevalence, and disability from the Global Burden of Disease Study 2019. Spine 47(21):1532–1540

Article  PubMed  PubMed Central  Google Scholar 

Zhang N, Yin Y, Xu SJ, Wu YP, Chen WS (2012) Inflammation & apoptosis in spinal cord injury. Indian J Med Res 135(3):287–296

CAS  PubMed  PubMed Central  Google Scholar 

Shi Z, Yuan S, Shi L, Li J, Ning G, Kong X et al (2021) Programmed cell death in spinal cord injury pathogenesis and therapy. Cell Prolif 54(3):e12992

Article  PubMed  PubMed Central  Google Scholar 

Liu X, Zhang Y, Wang Y, Qian T (2021) Inflammatory response to spinal cord injury and its treatment. World Neurosurg 155:19–31

Article  PubMed  Google Scholar 

He W, Li Z-q, Gu H-y, Pan Q-l, Lin F-x (2024) Targeted therapy of spinal cord injury: inhibition of apoptosis is a promising therapeutic strategy. Mol Neurobiol 61(7):4222–4239

Article  CAS  PubMed  Google Scholar 

Lin W, Stone S (2020) Unfolded protein response in myelin disorders. Neural Regen Res 15(4):636–645

Article  PubMed  Google Scholar 

Kaufman RJ (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13(10):1211–1233

Article  CAS  PubMed  Google Scholar 

Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397(6716):271–274

Article  CAS  PubMed  Google Scholar 

Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15(10):2025–2039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piperi C, Adamopoulos C, Dalagiorgou G, Diamanti-Kandarakis E, Papavassiliou AG (2012) Crosstalk between advanced glycation and endoplasmic reticulum stress: emerging therapeutic targeting for metabolic diseases. J Clin Endocrinol Metab 97(7):2231–2242

Article  CAS  PubMed  Google Scholar 

Liu M-q, Chen Z, Chen L-x (2016) Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases. Acta Pharmacol Sin 37(4):425–443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valenzuela V, Jackson KL, Sardi SP, Hetz C (2018) Gene therapy strategies to restore ER proteostasis in disease. Mol Ther 26(6):1404–1413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Penas C, Guzman MS, Verdu E, Fores J, Navarro X, Casas C (2007) Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. J Neurochem 102(4):1242–1255

Article  CAS  PubMed  Google Scholar 

Matthew JP, Joanne EM, Patrick MB, Isabelle B, Tammy CH, Cynthia DM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

Google Scholar 

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928

Article  PubMed  PubMed Central  Google Scholar 

Mhairi C, Joanne EM, Amanda S, Srinivasa Vittal K, Sue EB, Simon E et al (2020) Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ 368:l6890

Google Scholar 

Bigford GE, Bracchi-Ricard VC, Nash MS, Bethea JR (2012) Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age. PLoS ONE 7(7):e41073

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang SQ, Tang CL, Sun SQ, Yang C, Xu J, Wang KJ et al (2014) Demyelination initiated by oligodendrocyte apoptosis through enhancing endoplasmic reticulum-mitochondria interactions and Id2 expression after compressed spinal cord injury in rats. CNS Neurosci Ther 20(1):20–31

Article  PubMed  Google Scholar 

Wang JY, Li HYZ, Ren YC, Yao Y, Hu J, Zheng MZ et al (2018) Local delivery of beta-elemene improves locomotor functional recovery by alleviating endoplasmic reticulum stress and reducing neuronal apoptosis in rats with spinal cord injury. Cell Physiol Biochem 49(2):595–609

Article  CAS  PubMed  Google Scholar 

Shi D, He T, Tang W, Li H, Wang C, Zheng M et al (2019) Local application of MDL28170-loaded PCL film improves functional recovery by preserving survival of motor neurons after traumatic spinal cord injury. Neurosci Lett 694:161–167

Article  CAS  PubMed  Google Scholar 

Ohri SS, Bankston AN, Mullins SA, Liu Y, Andres KR, Beare JE et al (2018) Blocking autophagy in oligodendrocytes limits functional recovery after spinal cord injury. J Neurosci 38(26):5900–5912

Article  CAS  Google Scholar 

Ohri SS, Mullins A, Hetman M, Whittemore SR (2018) Activating transcription factor-6 alpha deletion modulates the endoplasmic reticulum stress response after spinal cord injury but does not affect locomotor recovery. J Neurotrauma 35(3):486–491

Article  Google Scholar 

Wu CY, Xu H, Li JF, Hu XL, Wang XY, Huang YJ, et al. Baicalein attenuates pyroptosis and endoplasmic reticulum stress following spinal cord ischemia-reperfusion injury via autophagy enhancement. Frontiers in Pharmacology. 2020;11.

Qi BC, Sun RJ, Rong JS, Peng ZB, Wang YS (2019) Cyclic adenosine phosphate improves functional recovery after spinal cord injury via activating unfolded protein response. Pharmazie 74(2):115–119

CAS  PubMed  Google Scholar 

Zhu Y, Zhang L, Fu R, Gao L, Feng G, Du C et al (2019) The change tendency of endoplasmic reticulum stress associated proteins in rats with spinal cord injury. Am J Transl Res 11(4):1938–1947

CAS  PubMed  PubMed Central  Google Scholar 

Ji Z, Zhou ZL, Hao Q, Zhao L, Cui C, Huang SB et al (2021) Activating transcription factor 6 contributes to functional recovery after spinal cord injury in adult zebrafish. J Mol Neurosci 71(4):734–745

Article  CAS  PubMed  Google Scholar 

Ohri SS, Maddie MA, Zhao YM, Qiu MS, Hetman M, Whittemore SR (2011) Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury. Glia 59(10):1489–1502

Article  PubMed  PubMed Central  Google Scholar 

Wan S, Shi P, Zhang X, Gu C, Fan S (2009) Stronger expression of CHOP and caspase 12 in diabetic spinal cord injury rats. Neurol Res 31(10):1049–1055

Article  CAS  PubMed  Google Scholar 

Dong Y, Yang SS, Fu B, Liu F, Zhou SN, Ding HQ et al (2020) Mechanism of tauroursodeoxycholic acid-mediated neuronal protection after acute spinal cord injury through AKT signaling pathway in rats. Int J Clin Exp Pathol 13(9):2218–2227

CAS  PubMed  PubMed Central  Google Scholar 

Lu X, Lv C, Zhao Y, Wang Y, Li Y, Ji C et al (2022) TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress. Stem Cell Res Ther 13(1):291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Zhang M, Li H, Li G, Jia Z, Sun P et al (2017) Berberine improves motor function recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis via AMPK activation in rats with spinal cord injury. Int J Clin Exp Pathol 10(4):4900–4911

CAS  Google Scholar 

Gu C, Li H, Wang C, Song X, Ding Y, Zheng M et al (2017) Bone marrow mes

Comments (0)

No login
gif