An, X., He, J., Xie, P., Li, C., Xia, M., Guo, D., et al. (2024). The effect of tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer’s disease. Free Radical Biology and Medicine, 224, 685–706. https://doi.org/10.1016/j.freeradbiomed.2024.09.021

Article  CAS  PubMed  Google Scholar 

Bao, C., Ma, Q., Ying, X., Wang, F., Hou, Y., Wang, D., et al. (2025). Histone lactylation in macrophage biology and disease: From plasticity regulation to therapeutic implications. EBioMedicine, 111, 105502. https://doi.org/10.1016/j.ebiom.2024.105502

Article  CAS  PubMed  Google Scholar 

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., et al. (2022). New insights into the genetic etiology of alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436. https://doi.org/10.1038/s41588-022-01024-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellouze, S., Baillat, G., Buttigieg, D., de la Grange, P., Rabouille, C., & Haase, G. (2016). Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons. Molecular Neurodegeneration, 11(1), Article 43. https://doi.org/10.1186/s13024-016-0111-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowden, J., Davey Smith, G., & Burgess, S. (2015). Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression. International Journal of Epidemiology, 44(2), 512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Burgess, S., & Thompson, S. G. (2011). Avoiding bias from weak instruments in Mendelian randomization studies. International Journal of Epidemiology, 40(3), 755–764. https://doi.org/10.1093/ije/dyr036

Article  PubMed  Google Scholar 

Burgess, S., Bowden, J., Fall, T., Ingelsson, E., & Thompson, S. G. (2017). Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants. Epidemiology (Cambridge, Mass.), 28(1), 30–42. https://doi.org/10.1097/ede.0000000000000559

Article  PubMed  Google Scholar 

Chen, J., Liu, Z., Yue, Z., Tan, Q., Yin, H., Wang, H., et al. (2025). EP300-mediated H3K18la regulation of METTL3 promotes macrophage ferroptosis and atherosclerosis through the m6A modification of SLC7A11. Biochimica et Biophysica Acta - General Subjects, 1869(9), 130838. https://doi.org/10.1016/j.bbagen.2025.130838

Article  CAS  PubMed  Google Scholar 

Cheng, J., & Zhao, H. (2024). NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells. Molecular Brain, 17(1), 81. https://doi.org/10.1186/s13041-024-01156-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng, Z., Huang, H., Li, M., & Chen, Y. (2024). Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells. IScience, 27(1), 108645. https://doi.org/10.1016/j.isci.2023.108645

Article  CAS  PubMed  Google Scholar 

Chia, R., Sabir, M. S., Bandres-Ciga, S., Saez-Atienzar, S., Reynolds, R. H., Gustavsson, E., et al. (2021). Genome sequencing analysis identifies new loci associated with lewy body dementia and provides insights into its genetic architecture. Nature Genetics, 53(3), 294–303. https://doi.org/10.1038/s41588-021-00785-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davey Smith, G., & Hemani, G. (2014). Mendelian randomization: Genetic anchors for causal inference in epidemiological studies. Human Molecular Genetics, 23(R1), R89–98. https://doi.org/10.1093/hmg/ddu328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies, N. M., Holmes, M. V., & Davey Smith, G. (2018). Reading Mendelian randomisation studies: A guide, glossary, and checklist for clinicians. BMJ (Clinical Research Ed.), 362, k601. https://doi.org/10.1136/bmj.k601

Article  PubMed  Google Scholar 

Greco, M. F., Minelli, C., Sheehan, N. A., & Thompson, J. R. (2015). Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Statistics in Medicine, 34(21), 2926–2940. https://doi.org/10.1002/sim.6522

Article  Google Scholar 

Guo, S., Zhu, W., Bian, Y., Li, Z., Zheng, H., Li, W., et al. (2024). Developing diagnostic biomarkers for Alzheimer’s disease based on histone lactylation-related gene. Heliyon, 10(18), Article e37807. https://doi.org/10.1016/j.heliyon.2024.e37807

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong, W., Zeng, X., Wang, H., Tan, X., Tian, Y., Hu, H., et al. (2024). PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis. Pharmacological Research, 205, 107228. https://doi.org/10.1016/j.phrs.2024.107228

Article  CAS  PubMed  Google Scholar 

Huang, H., Wang, S., Xia, H., Zhao, X., Chen, K., Jin, G., et al. (2024). Lactate enhances NMNAT1 lactylation to sustain nuclear NAD(+) salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions. Cancer Letters, 588, Article 216806. https://doi.org/10.1016/j.canlet.2024.216806

Article  CAS  PubMed  Google Scholar 

Jiao, Y., Ji, F., Hou, L., Lv, Y., & Zhang, J. (2024). Lactylation-related gene signature for prognostic prediction and immune infiltration analysis in breast cancer. Heliyon, 10(3), e24777. https://doi.org/10.1016/j.heliyon.2024.e24777

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., et al. (2023). FinnGen provides genetic insights from a well-phenotyped isolated population. Nature, 613(7944), 508–518. https://doi.org/10.1038/s41586-022-05473-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, Y., Wang, Y., Ke, Y., Zhao, Q., Fan, J., & Chen, Y. (2025). Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation. Frontiers in Cardiovascular Medicine, 12, 1567310. https://doi.org/10.3389/fcvm.2025.1567310

Article  PubMed  PubMed Central  Google Scholar 

Mi, J., Zhao, L., Shen, Y., Mo, S., & Kuang, Y. (2025). PFKP lactylation promotes the ovarian cancer progression through targeting PTEN. Biochemical Genetics, 63(6), 5294–5311. https://doi.org/10.1007/s10528-024-10990-4

Article  CAS  PubMed  Google Scholar 

Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., et al. (2021). Alzheimer’s disease. Lancet, 397(10284), 1577–1590. https://doi.org/10.1016/s0140-6736(20)32205-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, T., Zhou, Z., Xiang, T., Suo, Y., Shi, X., Li, Y., et al. (2024). Cytoskeleton dysfunction of motor neuron in spinal muscular atrophy. Journal of Neurology, 272(1), 19. https://doi.org/10.1007/s00415-024-12724-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slob, E. A. W., & Burgess, S. (2020). A comparison of robust Mendelian randomization methods using summary data. Genetic Epidemiology, 44(4), 313–329. https://doi.org/10.1002/gepi.22295

Article  PubMed  PubMed Central  Google Scholar 

Song, F., Hou, C., Huang, Y., Liang, J., Cai, H., Tian, G., et al. (2024). Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia. Cellular Signalling, 120, 111228. https://doi.org/10.1016/j.cellsig.2024.111228

Article  CAS  PubMed  Google Scholar 

Tian, Q., Li, J., Wu, B., Pang, Y., He, W., Xiao, Q., et al. (2025). APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci184656

Article  PubMed  PubMed Central  Google Scholar 

Tsukihara, S., Akiyama, Y., Shimada, S., Hatano, M., Igarashi, Y., Taniai, T., et al. (2025). Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer. Oncogene, 44(11), 724–738. https://doi.org/10.1038/s41388-024-03243-6