The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia

Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei JJ (2019) Endometriosis. Endocr Rev 40(4):1048–1079. https://doi.org/10.1210/er.2018-00242

Article  PubMed  PubMed Central  Google Scholar 

Pašalić E, Tambuwala MM, Hromić-Jahjefendić A (2023) Endometriosis: classification, pathophysiology, and treatment options. Pathol Res Pract 251:154847. https://doi.org/10.1016/j.prp.2023.154847

Article  CAS  PubMed  Google Scholar 

Allaire C, Bedaiwy MA, Yong PJ (2023) Diagnosis and management of endometriosis. Can Med Assoc J 195(10):E363–E371. https://doi.org/10.1503/cmaj.220637

Article  Google Scholar 

Crump J, Suker A, White L (2024) Endometriosis: a review of recent evidence and guidelines. Aust J Gen Pract 53(1–2):11–18. https://doi.org/10.31128/AJGP/04-23-6805

Trapero C, Vidal A, Fernández-Montolí ME, Coroleu B, Tresserra F, Barri P, Gómez de Aranda IG, Sévigny J, Ponce J, Matias-Guiu X, Martín-Satué M (2019) Impaired expression of ectonucleotidases in ectopic and eutopic endometrial tissue is in favor of ATP accumulation in the tissue microenvironment in endometriosis. Int J Mol Sci 20(22):5532. https://doi.org/10.3390/ijms20225532

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ecco JC, Soares AA, da Silva KET, Ansolin V, Sousa Silva GV, Silva RE, DT, (2025) Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation-a review of current literature. Inflamm Res 74(1):58. https://doi.org/10.1007/s00011-025-02023-6

Article  CAS  PubMed  Google Scholar 

Schrader J (2022) Ectonucleotidases as a bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock. Purinergic Signal 18:193–198. https://doi.org/10.1007%2Fs11302-022-09862-6

Liu JP, Liu SC, Hu SQ, Lu JF, Wu CL, Hu DX, Zhang WJ (2023) ATP ion channel P2X purinergic receptors in inflammation response. Biomed Pharmacother 158:114205. https://doi.org/10.1016/j.biopha.2022.114205

Article  CAS  PubMed  Google Scholar 

Taylor HS, Kotlyar AM, Flores VA (2021) Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397(10276):839–852. https://doi.org/10.1016/S0140-6736(21)00389-5

Article  CAS  PubMed  Google Scholar 

Vercellini P, Salmeri N, Somigliana E, Piccini M, Caprara F, Viganò P, De Matteis S (2024) Müllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation/implantation and the embryonic remnants/celomic metaplasia pathogenic theories: a systematic review and meta-analysis. Hum Reprod 39(7):1460–1470. https://doi.org/10.1093/humrep/deae086

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang T, De Carolis C, Man GCW, Wang CC (2018) The link between immunity, autoimmunity, and endometriosis: a literature update. Autoimmun Rev 17(10):945–955. https://doi.org/10.1016/j.autrev.2018.03.017

Article  CAS  PubMed  Google Scholar 

Wei Y, Liang Y, Lin H, Dai Y, Yao S (2020) Autonomic nervous system and inflammation interaction in? Endometriosis-associated pain J Neuroinflammation 17:80. https://doi.org/10.1186/s12974-020-01752-1

Article  PubMed  Google Scholar 

Atkins HM, Bharadwaj MS, Cox AO, Furdui CM, Appt SE, Caudell DL (2019) Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol 17:70. https://doi.org/10.1186/s12958-019-0513-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toniyan KA, Malkov AA, Biryukov NS, Gorbacheva EY, Boyarintsev VV, Ogneva IV (2024) The cellular respiration of endometrial biopsies from patients with various forms of endometriosis. Int J Mol Sci 25(7):3680. https://doi.org/10.3390/ijms25073680

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H (1870) Chang X (2023) Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages. Biochim Biophys Acta Mol Basis Dis 1:166895. https://doi.org/10.1016/j.bbadis.2023.166895

Article  CAS  Google Scholar 

Burnstock G, Campbell G, Satchell D, Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40(4):668–688. https://doi.org/10.1111/j.1476-5381.1970.tb10646.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burnstock G, Satchell DG, Smythe A (1972) A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species. Br J Pharmacol 46(2):234–242. https://doi.org/10.1111/j.1476-5381.1972.tb06868.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509–581

CAS  PubMed  Google Scholar 

Burnstock G (2012) Targeting the visceral purinergic system for pain control. Curr Opin Pharmacol 12(1):80–86. https://doi.org/10.1016/j.coph.2011.10.008

Article  CAS  PubMed  Google Scholar 

Zimmermann H (2021) History of ectonucleotidases and their role in purinergic signaling. Biochem Pharmacol 187:114322. https://doi.org/10.1016/j.bcp.2020.114322

Article  CAS  PubMed  Google Scholar 

Soares AA, dos Santos HM, Domann KN, Alves NPR, Böhm BR, Haack CM, Pretto KP, Guimarães ES, Rocha GF, de Paula IR, de Alcântara Guimarães LE, de Ávila Pessoa HC, Rodrigues RD, Dalagnol AMK, da Cunha MLV, de Resende e Silva DT, (2024) Purines and purinergic receptors in primary tumors of the central nervous system. Purinergic Signal. https://doi.org/10.1007/s11302-024-10053-8

Article  PubMed  PubMed Central  Google Scholar 

Timperi E, Barnaba V (2021) CD39 Regulation and functions in T cells. Int J Mol Sci 22(15):8068. https://doi.org/10.3390/ijms22158068

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giuliani AL, Sarti AC, Di Virgilio F (2019) Extracellular nucleotides and nucleosides as signaling molecules. Immunol Lett 205:16–24. https://doi.org/10.1016/j.imlet.2018.11.006

Article  CAS  PubMed  Google Scholar 

Spinaci A, Buccioni M, Dal Ben D, Marucci G, Volpini R, Lambertucci C (2021) P2X3 Receptor ligands: structural features and potential therapeutic applications. Front Pharmacol 12:653561. https://doi.org/10.3389/fphar.2021.653561

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krajewski JL (2020) P2X3-containing receptors as targets for the treatment of chronic pain. Neurotherapeutics 17(3):826–838. https://doi.org/10.1007/s13311-020-00934-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parke S, Gude K, Roth K, Messina F (2024) Efficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study. BMC Womens Health 24:353. ‌https://doi.org/10.1186/s12905-024-03188-8

Ding S, Zhu L, Tian Y, Zhu T, Huang X, Zhang X (2017) P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS ONE 12(9):e0184647. https://doi.org/10.1371/journal.pone.0184647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aliagas E, Vidal A, Torrejón-Escribano B, del Rosario TM, Ponce J, de Aranda IG, Sévigny J, Condom E, Martín-Satué M (2013) Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. Purinergic Signal 9:227–237. https://doi.org/10.1007/s11302-012-9345-0

Article  CAS  PubMed  Google Scholar 

Boggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A, Lalitkumar PG, Gemzell-Danielsson K (2016) Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form. Sci Rep 6:33811. https://doi.org/10.1038/srep33811

Article  CAS  PubMed 

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