Lopes A, Chammas R, Iyeyasu H (2013) Oncologia para a graduação. Lemar, São Paulo

Leonardi G, Falzone L, Salemi R, Zangh� A, Spandidos D, Mccubrey J, et al. Cutaneous melanoma: from pathogenesis to therapy (Review). Int J Oncol 2018. https://doi.org/10.3892/ijo.2018.4287

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N et al (2022) European consensus-based interdisciplinary guideline for melanoma. Part 1: diagnostics: Update 2022. Eur J Cancer 170:236–55. https://doi.org/10.1016/j.ejca.2022.03.008

Article  PubMed  Google Scholar 

da Silva GB, Yamauchi MA, Zanini D, Bagatini MD (2022) Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling. Purinergic Signal 18:61–81. https://doi.org/10.1007/s11302-021-09821-7

Article  PubMed  CAS  Google Scholar 

Baloghová J, Michalková R, Baranová Z, Mojžišová G, Fedáková Z, Mojžiš J (2023) Spice-derived phenolic compounds: potential for skin cancer prevention and therapy. Molecules 28:6251. https://doi.org/10.3390/molecules28176251

Article  PubMed  PubMed Central  CAS  Google Scholar 

Murai T, Matsuda S (2023) The chemopreventive effects of chlorogenic acids, phenolic compounds in coffee, against inflammation, cancer, and neurological diseases. Molecules 28:2381. https://doi.org/10.3390/molecules28052381

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mahmoud MA, Okda TM, Omran GA, Abd-Alhaseeb MM (2021) Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation. J Appl Biomed 19:202–9. https://doi.org/10.32725/jab.2021.024

Article  PubMed  Google Scholar 

Messeha SS, Zarmouh NO, Asiri A, Soliman KFA (2020) Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. Eur J Pharmacol 885:173419. https://doi.org/10.1016/j.ejphar.2020.173419

Article  PubMed  PubMed Central  CAS  Google Scholar 

Abdelwahab T, Abdelhamed R, Ali E, Mansour N, Abdalla M (2021) Evaluation of silver nanoparticles caffeic acid complex compound as new potential therapeutic agent against cancer incidence in mice. Asian Pacific J Cancer Prev 22:3189–201. https://doi.org/10.31557/APJCP.2021.22.10.3189

Article  CAS  Google Scholar 

Tseng J-C, Wang B-J, Wang Y-P, Kuo Y-Y, Chen J-K, Hour T-C et al (2023) Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells. Phytomedicine 116:154860. https://doi.org/10.1016/j.phymed.2023.154860

Article  PubMed  CAS  Google Scholar 

Chen C, Kuo Y-H, Lin C-C, Chao C-Y, Pai M-H, Chiang EPI et al (2020) Decyl caffeic acid inhibits the proliferation of colorectal cancer cells in an autophagy-dependent manner in vitro and in vivo. PLoS One 15:e0232832. https://doi.org/10.1371/journal.pone.0232832

Article  PubMed  PubMed Central  CAS  Google Scholar 

Caetano AR, Oliveira RD, Celeiro SP, Freitas AS, Cardoso SM, Gonçalves MST et al (2023) Phenolic compounds contribution to portuguese propolis anti-melanoma activity. Molecules 28:3107. https://doi.org/10.3390/molecules28073107

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kichina JV, Maslov A, Kandel ES (2023) PAK1 and therapy resistance in melanoma. Cells 12:2373. https://doi.org/10.3390/cells12192373

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kepp O, Bezu L, Yamazaki T, Di Virgilio F, Smyth MJ, Kroemer G, et al. ATP and cancer immunosurveillance. EMBO J 2021;40. https://doi.org/10.15252/embj.2021108130.

Vultaggio-Poma V, Falzoni S, Salvi G, Giuliani AL, Di Virgilio F (2022) Signalling by extracellular nucleotides in health and disease. Biochimica et Biophysica Acta (BBA) Mol Cell Res 1869:119237. https://doi.org/10.1016/j.bbamcr.2022.119237

Article  CAS  Google Scholar 

Savio LEB, Leite-Aguiar R, Alves VS, Coutinho-Silva R, Wyse ATS (2021) Purinergic signaling in the modulation of redox biology. Redox Biol 47:102137. https://doi.org/10.1016/j.redox.2021.102137

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakamura H, Takada K (2021) Reactive oxygen species in cancer: current findings and future directions. Cancer Sci 112:3945–3952. https://doi.org/10.1111/cas.15068

Article  PubMed  PubMed Central  CAS  Google Scholar 

da Silva JLG, Viana AR, Passos DF, Krause LMF, Miron VV, Schetinger MRC et al (2023) Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells. Purinergic Signal 19:633–650. https://doi.org/10.1007/s11302-022-09909-8

Article  PubMed  CAS  Google Scholar 

Ijaz S, Iqbal J, Abbasi BA, Ullah Z, Yaseen T, Kanwal S et al (2023) Rosmarinic acid and its derivatives: current insights on anticancer potential and other biomedical applications. Biomed Pharmacother 162:114687. https://doi.org/10.1016/j.biopha.2023.114687

Article  PubMed  CAS  Google Scholar 

Azhar MDK, Anwar S, Hasan GM, Shamsi A, Islam A, Parvez S et al (2023) Comprehensive insights into biological roles of rosmarinic acid: implications in diabetes, cancer and neurodegenerative diseases. Nutrients 15:4297. https://doi.org/10.3390/nu15194297

Article  PubMed  PubMed Central  CAS  Google Scholar 

Osakabe N (2003) Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 25:549–557. https://doi.org/10.1093/carcin/bgh034

Article  CAS  Google Scholar 

Huang L, Chen J, Quan J, Xiang D (2021) Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis. Bioengineered 12:3065–3076. https://doi.org/10.1080/21655979.2021.1941699

Article  PubMed  PubMed Central  CAS  Google Scholar 

Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15–31. https://doi.org/10.1016/j.immuni.2017.06.020

Article  PubMed  CAS  Google Scholar 

Strassheim D, Verin A, Batori R, Nijmeh H, Burns N, Kovacs-Kasa A et al (2020) P2Y purinergic receptors, endothelial dysfunction, and cardiovascular diseases. Int J Mol Sci 21:6855. https://doi.org/10.3390/ijms21186855

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alam M, Ahmed S, Elasbali AM, Adnan M, Alam S, Hassan MdI, et al. Therapeutic implications of caffeic acid in cancer and neurological diseases. Front Oncol 2022;12. https://doi.org/10.3389/fonc.2022.860508.

Kudugunti SK, Vad NM, Whiteside AJ, Naik BU, Yusuf MohdA, Srivenugopal KS et al (2010) Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines. Chem Biol Interact 188:1–14. https://doi.org/10.1016/j.cbi.2010.05.018

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pelinson LP, Assmann CE, Palma TV, da Cruz IBM, Pillat MM, Mânica A et al (2019) Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells. Mol Biol Rep 46:2085–2092. https://doi.org/10.1007/s11033-019-04658-1

Article  PubMed  CAS  Google Scholar 

Kimsa-Dudek M, Synowiec-Wojtarowicz A, Krawczyk A, Kosowska A, Kimsa-Furdzik M, Francuz T (2022) The apoptotic effect of caffeic or chlorogenic acid on the C32 cells that have simultaneously been exposed to a static magnetic field. Int J Mol Sci 23:3859. https://doi.org/10.3390/ijms23073859

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anwar J, Spanevello RM, Pimentel VC, Gutierres J, Thomé G, Cardoso A et al (2013) Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats. Food Chem Toxicol 56:459–466. https://doi.org/10.1016/j.fct.2013.02.030

Article  PubMed  CAS  Google Scholar 

Tao DL, Tassi Yunga S, Williams CD, McCarty OJT (2021) Aspirin and antiplatelet treatments in cancer. Blood 137:3201–3211.