Machala M, Procházková J, Hofmanová J, Králiková L, Slavík J, Tylichová Z, Ovesná P, Kozubík A, Vondráček J (2019) Colon Cancer and Perturbations of the Sphingolipid Metabolism. Int J Mol Sci 20(23):6051. https://doi.org/10.3390/ijms20236051

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mehta A, Patel BM (2019) Therapeutic opportunities in colon cancer: Focus on phosphodiesterase inhibitors. Life Sci 230:150–161. https://doi.org/10.1016/j.lfs.2019.05.043

Article  PubMed  CAS  Google Scholar 

Abdelmohsen K, Pullmann P Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol cell 25(4):543–557. https://doi.org/10.1016/j.molcel.2007.01.011

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doller A, Akool ES, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, Eberhardt W (2008) Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cδ elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol Cell Boil 28(8):2608–2625. https://doi.org/10.1128/MCB.01530-07

Article  CAS  Google Scholar 

Doller A, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, Eberhardt W (2007) Protein kinase Cα-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell 18(6):2137–2148. https://doi.org/10.1091/mbc.e06-09-0850

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ghosh JC, Seo JH, Agarwal E, Wang Y, Kossenkov AV, Tang HY, Speicher DW, Altieri DC (2019) Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits. Oncogene 38:6926–6939. https://doi.org/10.1038/s41388-019-0939-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nesci S, Trombetti F, Algieri C, Pagliarani A (2019) A therapeutic role for the F1FO-ATP synthase. SLAS Discov 24(9):893–903. https://doi.org/10.1177/2472555219860448

Article  PubMed  CAS  Google Scholar 

Lee HE, Lee JY, Yang G, Kang HC, Cho YY, Lee HS, Lee JY (2019) Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells. Sci Rep 9(1):12277. https://doi.org/10.1038/s41598-019-48794-x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bergamin LS, Capece M, Salaro E, Sarti AC, Falzoni S, Pereira MS, De Bastiani MA, Scholl JN, Battastini AM, Di Virgilio F (2019) Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth. Oncotarget 10(47):4840–4856. https://doi.org/10.18632/oncotarget.27106

Article  PubMed  PubMed Central  Google Scholar 

Cao Y, Wang X, Li Y, Evers M, Zhang H, Chen X (2019) Extracellular and macropinocytosis internalized ATP work together to induce epithelial–mesenchymal transition and other early metastatic activities in lung cancer. Cancer Cell Int 19:254. https://doi.org/10.1186/s12935-019-0973-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hinman MN, Lou H (2008) Diverse molecular functions of Hu proteins. Cell Mol Life Sci 65:3168–3181. https://doi.org/10.1007/s00018-008-8252-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M (2000) HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 19(10):2340–2350. https://doi.org/10.1093/emboj/19.10.2340

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yam CH, Fung TK, Poon RY (2002) Cyclin A in cell cycle control and cancer. CMLS, Cell Mol Life Sci 59(8):1317–1326. https://doi.org/10.1007/s00018-002-8510-y

Article  PubMed  CAS  Google Scholar 

Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK (2009) Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells. Mol Cancer Res 7(8):1354–1366. https://doi.org/10.1158/1541-7786.MCR-08-0476

Article  PubMed  CAS  Google Scholar 

Lal A, Kawai T, Yang X, Mazan-Mamczarz K, Gorospe M (2005) Antiapoptotic function of RNA-binding protein HuR effected through prothymosin α. EMBO J 24(10):1852–1862. https://doi.org/10.1038/sj.emboj.7600661

Article  PubMed  PubMed Central  CAS  Google Scholar 

Phillips CM, Lima EA, Woodall RT, Brock A, Yankeelov TE (2020) A hybrid model of tumor growth and angiogenesis: In silico experiments. PLoS ONE 15(4):e0231137. https://doi.org/10.1371/journal.pone.0231137

Article  PubMed  PubMed Central  CAS  Google Scholar 

Masuda K, Abdelmohsen K, Gorospe M (2009) RNA-binding proteins implicated in the hypoxic response. J Cell Mol Med 13(9a):2759–2769. https://doi.org/10.1111/j.1582-4934.2009.00842.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Galbán S, Gorospe M (2009) Factors interacting with HIF-1α mRNA: novel therapeutic targets. Curr Pharm Des 15(33):3853–3860. https://doi.org/10.2174/138161209789649376

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Zhao W, Guo Y, Zhang B, Xie Q, Xiang D, Gao J, Wang B, Chen Z (2009) The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis. Oncology 76(6):420–429. https://doi.org/10.1159/000216837

Article  PubMed  CAS  Google Scholar 

Beck C, Schreiber H, Rowley DA (2001) Role of TGF-β in immune-evasion of cancer. Microsc Res Tech 52(4):387–395. https://doi.org/10.1002/1097-0029

Article  PubMed  CAS  Google Scholar 

Soni S, Anand P, Padwad YS (2019) MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression. J Exp Clin Cancer Res 38(1):121. https://doi.org/10.1186/s13046-019-1115-1

Article  PubMed  PubMed Central  Google Scholar 

Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2(3):161–174. https://doi.org/10.1038/nrc745

Article  PubMed  CAS  Google Scholar 

Deryugina EI, Quigley JP (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25(1):9–34. https://doi.org/10.1007/s10555-006-7886-9

Article  PubMed  CAS  Google Scholar 

Takeuchi T, Hisanaga M, Nagao M, Ikeda N, Fujii H, Koyama F, Mukogawa T, Matsumoto H, Kondo S, Takahashi C, Noda M (2004) The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clin Cancer Res 10(16):5572–5579. https://doi.org/10.1158/1078-0432.CCR-03-0656

Article  PubMed  CAS  Google Scholar 

Huwiler A, Akool ES, Aschrafi A, Hamada FM, Pfeilschifter J, Eberhardt W (2003) ATP potentiates interleukin-1β-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR. J Biol Chem 278(51):51758–51769. https://doi.org/10.1074/jbc.M305722200

Article  PubMed  CAS  Google Scholar 

Elsayed AM, Abdelghany TM, Akool el-S, Abdel-Aziz AA, Abdel-Bakky MS (2016) All-trans retinoic acid potentiates cisplatin-induced kidney injury in rats: impact of retinoic acid signaling pathway. Naunyn Schmiedebergs Arch Pharmacol 389(3):327–337. https://doi.org/10.1007/s00210-015-1193-3

Article  PubMed  CAS