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Investigate sodium orthovanadate molecular mechanisms in diabetes-aggravated ulcerative colitis, focusing on Nrf2/Keap1 antioxidant and NF-κB/IL-6 inflammatory pathways
Investigate sodium orthovanadate molecular mechanisms in diabetes-aggravated ulcerative colitis, focusing on Nrf2/Keap1 antioxidant and NF-κB/IL-6 inflammatory pathways
Ulcerative colitis (UC) is a long-term inflammatory condition affecting the colon’s lining starting from the rectum ...
Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network
Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network
Cryptorchidism is caused by a combination of environmental and genetic variables. This study aimed to identify cryptorchid...
METTL14 mitigates osteoporosis progression by promoting osteogenic differentiation of BMMSCs through improving mitochondrial dysfunction
METTL14 mitigates osteoporosis progression by promoting osteogenic differentiation of BMMSCs through improving mitochondrial dysfunction
Osteoporosis, a prevalent metabolic bone disorder characterized by diminished bone mass and microarchitectural deteriorati...
Fargesin enhances the condition of intervertebral disc degeneration by suppressing BRD4 expression and influencing autophagy in NPCs
Fargesin enhances the condition of intervertebral disc degeneration by suppressing BRD4 expression and influencing autophagy in NPCs
Intervertebral Disc Degeneration (IVDD) stands as the prevalent chronic skeletal muscle degenerative disease and the prima...
The role of microbiota derived metabolites in modulating diabetic inflammation: a systematic review
The role of microbiota derived metabolites in modulating diabetic inflammation: a systematic review
Emerging evidence indicates that gut microbiota-derived metabolites (MDMs) modulate immune and metabolic pathways relevant...
Effect of targeted regulation of miR-499a-5p/integrin β1 by circ_001567 on malignant progression of gastric cancer cells
Effect of targeted regulation of miR-499a-5p/integrin β1 by circ_001567 on malignant progression of gastric cancer cells
To investigate the effect of targeted regulation of miR-499a-5p/integrin β1 (ITGB1) by circ_001567 on malignant progr...
Acupuncture modulates actin homeostasis and promotes myelin sheath regeneration in rat models of intracerebral hemorrhage
Acupuncture modulates actin homeostasis and promotes myelin sheath regeneration in rat models of intracerebral hemorrhage
The relationship between actin dynamics and remyelination after intracerebral hemorrhage (ICH) remains unclear. This study...
The role and mechanism of 3D-printed hydrogel-CGF/PLGA composite polymer in promoting skin burn healing
The role and mechanism of 3D-printed hydrogel-CGF/PLGA composite polymer in promoting skin burn healing
Skin burn healing faces challenges, including delayed wound closure, high infection risk, and scar formation, necessitatin...
Colonic inflammatory response in a D-galactose-induced aging model: elevated IL-1β expression
Colonic inflammatory response in a D-galactose-induced aging model: elevated IL-1β expression
Aging is a long-term and complex process characterized by cellular changes, including cell cycle arrest, increased product...
Identification and validation of GNA15 as a novel diagnostic biomarker in ulcerative colitis
Identification and validation of GNA15 as a novel diagnostic biomarker in ulcerative colitis
Despite advances in transcriptomic profiling, reliable diagnostic biomarkers that accurately reflect disease activity and ...
Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia
Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia
Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and systemic inflammation, often drive...
EpCAM as a novel target of MARCH8: implications for esophageal squamous cell carcinoma progression
EpCAM as a novel target of MARCH8: implications for esophageal squamous cell carcinoma progression
Emerging evidence suggests a crucial role of MARCH8, a membrane-associated RING-E3 ubiquitin ligase, in cancer progression...
Development of metabolic syndrome by increasingly fructose-enriched water in Wistar rats
Development of metabolic syndrome by increasingly fructose-enriched water in Wistar rats
Several studies have shown that excessive fructose consumption increases the risk of developing metabolic syndrome (MS), w...
Histomorphological analysis of the relationship between infection of the gastric mucosa and host immunity strength
Histomorphological analysis of the relationship between infection of the gastric mucosa and host immunity strength
The objective of this study was to investigate the histomorphological characteristics of H. pylori colonization in the gas...
Silencing soluble epoxide hydrolase protects against myocardial ischemia–reperfusion injury through modulation of the YAP signaling pathway and macrophage polarization
Silencing soluble epoxide hydrolase protects against myocardial ischemia–reperfusion injury through modulation of the YAP signaling pathway and macrophage polarization
The objective of this study was to examine the impact of soluble epoxide hydrolase (sEH) on myocardial ischemia–repe...
L. extracts attenuate polycystic ovarian syndrome in letrozole treated female Wistar rats through modulation of iNOS, COX-2, IL-1β and TNF-α
L. extracts attenuate polycystic ovarian syndrome in letrozole treated female Wistar rats through modulation of iNOS, COX-2, IL-1β and TNF-α
Polycystic ovary syndrome (PCOS) is a prevalent endocrine abnormality affecting the women of child bearing age. PCOS marke...
polysaccharides alleviate atopic dermatitis in vivo and in vitro through inhibition of inflammation and mitochondrial dysfunction
polysaccharides alleviate atopic dermatitis in vivo and in vitro through inhibition of inflammation and mitochondrial dysfunction
Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by immune dysregulation and oxidative stress. Curren...
extract as prebiotic and as probiotic intervention mitigated histological changes in DNCB-induced colitis via GLP-1/Nrf2/NF-κB axis regulation
extract as prebiotic and as probiotic intervention mitigated histological changes in DNCB-induced colitis via GLP-1/Nrf2/NF-κB axis regulation
Ulcerative colitis is a debilitating inflammatory bowel disorder characterized by epithelial damage, oxidative stress, and...
Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis
Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis
Bladder cancer (BC), a leading urogenital malignancy with high mortality, lacks effective early biomarkers. Connexin 43 (C...
CEP78 regulates the proliferation and angiogenesis of endothelial cells by mediating microtubule stabilization via p150glued
CEP78 regulates the proliferation and angiogenesis of endothelial cells by mediating microtubule stabilization via p150glued
Angiogenesis, the sprouting of neovasculature from established vessels, is an essential biological process for wound heali...
Nature’s shield: ginseng as a neuroprotective agent against titanium dioxide nanoparticle exposure
Nature’s shield: ginseng as a neuroprotective agent against titanium dioxide nanoparticle exposure
Titanium dioxide nanoparticles (TiO₂-NPs) are widely used in various industries due to their unique properties. Howe...
Dihydromyricetin protects hippocampal neurons in sepsis-associated encephalopathy by reducing ER stress-mediated apoptosis and inflammation
Dihydromyricetin protects hippocampal neurons in sepsis-associated encephalopathy by reducing ER stress-mediated apoptosis and inflammation
Sepsis-associated encephalopathy (SAE) involves hippocampal dysfunction and cognitive deficits, but its underlying mechani...
Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis
Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis
As a common chronic disease, endometriosis (EMs) affects nearly 10% of women of childbearing age, may cause other complica...
Hippo signaling pathway in human testis and seminoma: anticancer effect of verteporfin on human seminoma TCam-2 cells
Hippo signaling pathway in human testis and seminoma: anticancer effect of verteporfin on human seminoma TCam-2 cells
Seminoma and embryonal carcinoma are among the most common germ cell tumors. Verteporfin, a YAP-TEAD inhibitor, has emerge...
Immunohistochemical examination of CD163 and TROP2 expression levels in ovarian endometriosis
Immunohistochemical examination of CD163 and TROP2 expression levels in ovarian endometriosis
Endometriosis is described as an estrogen-associated, chronic, inflammatory disorder characterized by ectopic endometrial ...
NLRP3 promotes NK cell-mediated cytotoxicity and inhibits colorectal cancer development via the NKG2D signaling pathway
NLRP3 promotes NK cell-mediated cytotoxicity and inhibits colorectal cancer development via the NKG2D signaling pathway
Colorectal cancer progression involves tumor metastasis and immune evasion, with the NOD-like receptor family, pyrin domai...
Prenatal and pubertal exposure to ethinylestradiol induces Long-Term stromal and epithelial changes in the gerbil dorsal prostate
Prenatal and pubertal exposure to ethinylestradiol induces Long-Term stromal and epithelial changes in the gerbil dorsal prostate
17α-Ethinylestradiol (EE2) is a synthetic estrogen derived from 17β-estradiol and widely used in oral contracept...
Ephrin-B1 and EphB4 expression and localization in steroidogenic cells of mouse adrenal gland
Ephrin-B1 and EphB4 expression and localization in steroidogenic cells of mouse adrenal gland
Erythropoietin-producing hepatocellular (Eph) receptors and their ligands ephrin are membrane-bound molecules that modulat...
Voacangine targeting of PI3K/Akt/ERK via the knockdown of inflammation in DEN-induced liver cancer: in vivo and in silico approach
Voacangine targeting of PI3K/Akt/ERK via the knockdown of inflammation in DEN-induced liver cancer: in vivo and in silico approach
Hepatocellular carcinoma (HCC) is a type of primary liver cancer characterized by inflammation and liver damage. It is a s...
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway
Chronic kidney disease (CKD) is an epidemic with higher cardiovascular risk, and this pathology involves renal injury and ...
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