SCI Abstract

search
+
Post-translational modifications regulating microglial inflammation in central nervous system disorders: a review
Post-translational modifications regulating microglial inflammation in central nervous system disorders: a review
Microglia, the primary immune cells of the central nervous system, play a pivotal role in orchestrating neuroinflammatory ...
Arthritogenicity of CD11b + Gr1 + myeloid cells is dependent on dual specificity phosphatase 6 (DUSP6)
Arthritogenicity of CD11b + Gr1 + myeloid cells is dependent on dual specificity phosphatase 6 (DUSP6)
The dual specificity phosphatase 6 (DUSP6) was recently implicated in autoimmune arthritis pathogenesis. However, it remai...
Regulation of macrophage transcriptional dynamics during acute and chronic wound repair
Regulation of macrophage transcriptional dynamics during acute and chronic wound repair
Wound healing is a complex and tightly controlled physiological process that involves various cell types, among which macr...
LPCAT3—dependent remodeling of the phospholipids and lipid rafts is essential for vascular proinflammatory signaling and the development of atherosclerosis
LPCAT3—dependent remodeling of the phospholipids and lipid rafts is essential for vascular proinflammatory signaling and the development of atherosclerosis
Lysophosphatidyl choline acyltransferase 3 (LPCAT3) is crucially involved in the remodeling of phospholipids in the membra...
The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
Psoriatic disease (PsD) is a chronic systemic inflammatory condition associated with significant cardiometabolic comorbidi...
Transcriptomic profiling reveals a dramatic inflammatory shift in osteal macrophages during colitis-induced osteoporosis
Transcriptomic profiling reveals a dramatic inflammatory shift in osteal macrophages during colitis-induced osteoporosis
Colitis disrupts the intestinal barrier, leading to increased permeability and the translocation of harmful microbial comp...
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis has been associated with an increased risk of atherosclerotic cardiovascular disease; however, its associati...
Novel insights into the effect of sTIM-3 on NLRP3 inflammasome via interacting with ASC
Novel insights into the effect of sTIM-3 on NLRP3 inflammasome via interacting with ASC
T cell immunoglobulin and mucin-domain containing-3 (TIM-3) plays a critical regulatory role in a variety of diseases. Hum...
The OX40-OX40L Co-stimulatory pathway in dermatology: emerging frontiers for therapeutic approaches
The OX40-OX40L Co-stimulatory pathway in dermatology: emerging frontiers for therapeutic approaches
The OX40/OX40L co-stimulatory signaling pathway plays a crucial role in T cell activation, differentiation, expansion, and...
Commentary on “CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1”
Commentary on “CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1”
In Liu’s report, the murine cell line RAW264.7 was used in vitro experimental analysis. The authors demonstrated that knoc...
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke, although arising from microbial infection or environmental heat exposure, converge upon similar pat...
Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1
Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1
Mitogen-activated protein kinase phosphatase-1 (MKP-1) is an anti-inflammatory enzyme whose expression is increased by glu...
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Rosacea is a chronic inflammatory skin disorder characterized by symptoms like itching, redness, and impaired skin barrier...
Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsur...
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Skin lesions in atopic dermatitis (AD) are characterized by elevated levels of both Th1 and Th2 cytokines, along with incr...
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinins, bioactive peptides produced through the proteolytic activity of kallikrein1, are members of the kallikrein-kinin s...
LncRNA TYMSOS stimulates immune escape and the advancement of cervical squamous cell carcinoma by regulating miR-134-5p/KRAS expression
LncRNA TYMSOS stimulates immune escape and the advancement of cervical squamous cell carcinoma by regulating miR-134-5p/KRAS expression
LncRNAs can regulate related miRNAs and participate in the regulation of tumorigenesis, progression, and immune escape in ...
Genetic mechanisms of pollinosis: interactions between genes and environmental factors
Genetic mechanisms of pollinosis: interactions between genes and environmental factors
Pollinosis, or pollen-induced allergic rhinitis, results from complex interactions among genetic susceptibility, environme...
Effects of curcumin and extract on inflammatory biomarkers in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE): a systematic review and meta-analysis of randomized controlled trials
Effects of curcumin and extract on inflammatory biomarkers in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE): a systematic review and meta-analysis of randomized controlled trials
Curcumin and Curcuma longa extract have been proposed as adjunct therapies for autoimmune diseases such as rheumatoid arth...
Serine metabolism in macrophage polarization
Serine metabolism in macrophage polarization
Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of ...
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Atherosclerosis, characterized by abnormal arterial lipid deposition, is an age-dependent inflammatory disease and contrib...
Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
Oncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with up...
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by hyperplastic synovium, pannus formation, immun...
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
Increased O-linked β-N-acetylglucosamine (O-GlcNAc) stimulation has been reported to protect against sepsis associate...
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Sepsis may often result in acute lung injury (ALI), with a high mortality and morbidity. Available evidence indicates that...
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Postoperative cognitive dysfunction (POCD) is a neurological complication occurring after anesthesia and surgery. Neuroinf...
Effects of neutrophil fate on inflammation
Effects of neutrophil fate on inflammation
Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infe...
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
Kidney stones commonly occur with a 50% recurrence rate within 5 years, and can elevate the risk of chronic kidne...
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typi...
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 muta...
Load More
format_indent_increase