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Single-Cell Transcriptomics Identifies a Pivotal Role of SPHK1 Macrophage-Driven Inflammation in Mechanism of Aortic Dissection and Highlights SPHK1 as a Therapeutic Target
Single-Cell Transcriptomics Identifies a Pivotal Role of SPHK1 Macrophage-Driven Inflammation in Mechanism of Aortic Dissection and Highlights SPHK1 as a Therapeutic Target
Macrophages are a key heterogeneous cell population involved in the pathogenesis and progression of acute aortic dissectio...
Adipose-Derived Proinflammatory Visfatin Promotes Vascular Calcification via TLR4 and is Suppressed by Empagliflozin
Adipose-Derived Proinflammatory Visfatin Promotes Vascular Calcification via TLR4 and is Suppressed by Empagliflozin
Vascular calcification, a common complication of metabolic diseases such as diabetes and obesity, is closely associated wi...
Dendritic Cells Derived MMP9 Fuels Sepsis-Induced Cardiac Dysfunction Through JNK/AP1 Driven Pro-Inflammatory Cytokine and Nitric Oxide Storm
Dendritic Cells Derived MMP9 Fuels Sepsis-Induced Cardiac Dysfunction Through JNK/AP1 Driven Pro-Inflammatory Cytokine and Nitric Oxide Storm
Metalloproteinase9 is an important inflammatory mediator, but its contribution to sepsis-induced myocardial dysfunction (S...
The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions
The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions
Neutrophils incubated on ICAM-1- or fibrinogen- coated plates produced histamine in response to fMLP indicating that hista...
C7ORF41 Alleviates Ferroptosis Via the Keap1/Nrf2/HO-1 Axis in Endotoxin-Associated Acute Kidney Injury
C7ORF41 Alleviates Ferroptosis Via the Keap1/Nrf2/HO-1 Axis in Endotoxin-Associated Acute Kidney Injury
Endotoxin-associated acute kidney injury (EA-AKI) is a critical complication in intensive care units. Ferroptosis, an iron...
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP
C-reactive protein (CRP) is a highly conserved pentraxin, synthesized primarily in the liver, and is widely recognized as ...
HAPLN1 Exhibits Dual Effects: Facilitating Extracellular Matrix Restoration while Enhancing Inflammatory Mediator Production in Arthritic Chondrocytes
HAPLN1 Exhibits Dual Effects: Facilitating Extracellular Matrix Restoration while Enhancing Inflammatory Mediator Production in Arthritic Chondrocytes
Hyaluronan and proteoglycan link protein 1 (HAPLN1) secreted by fibroblast-like synoviocytes (FLSs) plays a critical role ...
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice
Ferroptosis is closely associated with the various pathological manifestations of asthma. This study aimed to explore the ...
Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil Elastase
Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil Elastase
It is suggested that neutrophil adhesion to P-selectin (P-sel) on activated platelet can induce P-sel shedding, however, t...
The Role of CCL11-CCR3 Induced Mitochondrial Dysfunction and Oxidative Stress in Cognitive Impairment in Early-onset Schizophrenia: Insights from Preclinical Studies
The Role of CCL11-CCR3 Induced Mitochondrial Dysfunction and Oxidative Stress in Cognitive Impairment in Early-onset Schizophrenia: Insights from Preclinical Studies
Abnormal cytokine expression has been implicated as a potential contributor to neurodegeneration. This study aimed to inve...
Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium
Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium
Macrophages play a significant role in the repair of endometrial injuries. While large peritoneal macrophages (LPMs) have ...
Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M
Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M
There is a recognized longitudinal association between serum nitrogen oxides levels and disease activity in lupus nephriti...
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of
Mutations in the WFS1 gene, encoding wolframin (WFS1), are known to cause endoplasmic reticulum (ER) stress and lead to Wo...
Inflammatory Association between Periodontal Disease and Systemic Health
Inflammatory Association between Periodontal Disease and Systemic Health
Periodontitis is an oral disease that affects almost half of the adult population in United States. The complex relationsh...
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4
Hypertension serves as a major contributing factor to various cardiovascular disorders, including heart failure. Ferroptos...
Inactivated R0179 Inhibits -Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis
Inactivated R0179 Inhibits -Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis
This study aims to explore the mechanism by which heat-inactivated Bacillus subtilis (B. subtilis) R0179 modulates the TLR...
Neutrophil Heterogeneity in Airway Inflammatory Diseases
Neutrophil Heterogeneity in Airway Inflammatory Diseases
Neutrophils, the most abundant circulating leukocytes in humans, play key roles in infection and inflammation. The lungs r...
Chemerin Exacerbates Pulmonary Inflammation in Type 2 Diabetes and Infection Comorbidity
Chemerin Exacerbates Pulmonary Inflammation in Type 2 Diabetes and Infection Comorbidity
The adipokine chemerin is increased in the serum of individuals with obesity and type 2 diabetes. Patients with type 2 dia...
Angiotensin-(1–7) Mitigates Progression from Acute Kidney Injury to Chronic Kidney Disease Via Renin-Angiotensin System Modulation in a Murine Model
Angiotensin-(1–7) Mitigates Progression from Acute Kidney Injury to Chronic Kidney Disease Via Renin-Angiotensin System Modulation in a Murine Model
Background. Acute kidney injury (AKI) often progresses to chronic kidney disease (CKD), presenting a significant ...
Identification and Experimental Validation of OS-Related Gene Sets Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data with Machine Learning in Patients with Sepsis
Identification and Experimental Validation of OS-Related Gene Sets Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data with Machine Learning in Patients with Sepsis
Sepsis is a severe organ dysfunction syndrome caused by a dysregulated host response to infection, closely associated with...
Evaluation of Cardiac IL-11 and IL-11Rα Expression During Infection
Evaluation of Cardiac IL-11 and IL-11Rα Expression During Infection
Chagas disease (CD), caused by Trypanosoma cruzi, leads to cardiomyopathy in approximately 20–30% of infected indivi...
Elevated IL-17A-Secreting Regulatory T Cells in Sinonasal Tissues of Chronic Rhinosinusitis with Nasal Polyps
Elevated IL-17A-Secreting Regulatory T Cells in Sinonasal Tissues of Chronic Rhinosinusitis with Nasal Polyps
During nasal polyp (NP) development, activated T cells differentiate into T helper (Th) 1, Th2, and Th17 cells. Additional...
Fecal Microbiota Transplantation Alleviates Airway Inflammation in Asthmatic Rats by Increasing the Level of Short-Chain Fatty Acids in the Intestine
Fecal Microbiota Transplantation Alleviates Airway Inflammation in Asthmatic Rats by Increasing the Level of Short-Chain Fatty Acids in the Intestine
Asthma is a prevalent chronic inflammatory disorder of the respiratory tract that not only manifests with respiratory symp...
Evaluating the Anti-inflammatory Potential of JN-KI3: The Therapeutic Role of PI3Kγ-Selective Inhibitors in Asthma Treatment
Evaluating the Anti-inflammatory Potential of JN-KI3: The Therapeutic Role of PI3Kγ-Selective Inhibitors in Asthma Treatment
Asthma is a chronic airway inflammatory disease of the airways characterized by the involvement of numerous inflammatory c...
UVB Induces Sympathetic Nervous System Activation and Norepinephrine Secretion to Regulate The Skin Color of Mice Through the β2-AR/AP-1 Pathway in Epidermal Keratinocytes
UVB Induces Sympathetic Nervous System Activation and Norepinephrine Secretion to Regulate The Skin Color of Mice Through the β2-AR/AP-1 Pathway in Epidermal Keratinocytes
The aim of this study was to investigate how ultraviolet B (UVB) light regulates AP-1 expression via the β2-adrenergi...
Dnmt3a-mediated DNA Methylation Regulates P. gingivalis-suppressed Cementoblast Mineralization Partially Via Mitochondria-dependent Apoptosis Pathway
Dnmt3a-mediated DNA Methylation Regulates P. gingivalis-suppressed Cementoblast Mineralization Partially Via Mitochondria-dependent Apoptosis Pathway
DNA methyltransferase 3A (Dnmt3a) is an enzyme that catalyzes the de novo methylation of DNA, and plays essential roles in...
Piezo1-Induced Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis
Piezo1-Induced Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis
This study aimed to investigate the role of Piezo1 in nasal epithelial barrier dysfunction in allergic rhinitis (AR) using...
Identification and Construction of a R-loop Mediated Diagnostic Model and Associated Immune Microenvironment of COPD through Machine Learning and Single-Cell Transcriptomics
Identification and Construction of a R-loop Mediated Diagnostic Model and Associated Immune Microenvironment of COPD through Machine Learning and Single-Cell Transcriptomics
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic inflammatory airway disease with high incidence and si...
Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation
Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation
Macrophages exhibit diverse phenotypes depending on environment status, which contribute to physiological and pathological...
Topical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption
Topical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption
Atopic dermatitis (AD) is a multifaceted inflammatory skin condition characterized by the involvement of various cell type...
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