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Glutathione regulates CIA-activated splenic-lymphocytes via NF-κB/MMP-9 and MAPK/PCNA pathways manipulating immune response
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Exploration of immunomodulatory mechanism of caprine Wharton’s jelly derived mesenchymal stem cells
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Metallothionein-1 mitigates the advancement of osteoarthritis by regulating Th17/Treg balance
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Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes
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Evaluation of TNF-α and IFN-γ primed conditioned medium of mesenchymal stem cell in acetic acid-induced mouse model of acute colitis
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Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models
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Netosis and trained immunity in tick-borne diseases: a possible pathogenetic role
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Unveiling the impact of TREM-2+ Macrophages in metabolic disorders
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House dust mite allergen directly activates ILC2 cells via the TLR4 signaling pathway in allergic airway diseases
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IL-10: A Key Regulator and potential therapeutic target in uveitis
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B cell-intrinsic IFN-γ promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice
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Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages
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Drug screening identifies pyrrolidinedithiocarbamate ammonium ameliorating DSS-induced mouse ulcerative colitis via suppressing Th17 differentiation
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Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases
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P2RX1-blocked neutrophils induce CD8+ T cell dysfunction and affect the immune escape of gastric cancer cells
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Berberine shaping the tumor immune landscape via pyroptosis
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Ubiquitination and degradation of MHC-II by Tim-3 inhibits antiviral immunity
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Immunomodulation by galectin-9: Distinct role in T cell populations, current therapeutic avenues and future potential
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The CCL5/CCR5 axis in ulcerative colitis
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Natural killer cell-based therapies in neuroblastoma
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Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Newborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-ut...
Loss of B1 and marginal zone B cells during ovarian cancer
Loss of B1 and marginal zone B cells during ovarian cancer
Immunity evolved not only to resist external challenges but also to serve in an internal, “housekeeping” function that ope...
Differential roles of regulatory T cells in Alzheimer's disease
Differential roles of regulatory T cells in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the major cause of dementia. Progressive memory l...
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Asthma is a chronic respiratory disease that is characterized by airway inflammation and non-specific bronchial hyperrespo...
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Inflammatory bowel disease (IBD) is clinically classified as ulcerative colitis (UC) and Crohn’s disease (CD). Although th...
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein 1/anti-programmed cell death 1 ligand 1 (P...
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
Wiskott-Aldrich syndrome (WAS) is a rare disorder caused by an X-linked genetic mutation that causes immune deficiency and...
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Sarcoidosis is a systemic inflammatory disease with significant morbidity and increased mortality and affects patients of ...
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
Due to the central role in immune surveillance, the antigen peptide hold tremendous promise for treatment modalities in ca...
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
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