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Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway
Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway
The growth of human pulmonary arterial smooth muscle cells (hPASMCs) is one of the key contributors to vascular remodeling...
Chebulagic acid targets FBXO38 to enhance natural killer cell-mediated anti-tumor immunity in lung adenocarcinoma
Chebulagic acid targets FBXO38 to enhance natural killer cell-mediated anti-tumor immunity in lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most prevalent and aggressive form of non-small cell lung cancer. Natural compounds have g...
Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway
Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway
Ethambutol (EMB)-induced optic neuropathy (EON) is a clinical concern. Ferroptosis, involving iron and toxic reactive oxyg...
Hsa_circ_0003176: a key player in the m6A modification-mediated regulation of autophagy and glycolysis in cisplatin-resistant non-small cell lung cancer
Hsa_circ_0003176: a key player in the m6A modification-mediated regulation of autophagy and glycolysis in cisplatin-resistant non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, with poor prognosis largely a...
The Hippo pathway in cardiac fibrosis: mechanisms and therapeutic prospects
The Hippo pathway in cardiac fibrosis: mechanisms and therapeutic prospects
Cardiac fibrosis is a prevalent pathological feature in the progression of various cardiovascular diseases, including hear...
Construction of a risk model based on exosome-related genes predict clinical prognosis and therapeutic response and revealing as a promising target in colorectal cancer
Construction of a risk model based on exosome-related genes predict clinical prognosis and therapeutic response and revealing as a promising target in colorectal cancer
Various exosome-derived proteins have been reported to play essential roles in regulating colorectal cancer progression an...
The interplay between circadian rhythm components and apoptosis in health and disease
The interplay between circadian rhythm components and apoptosis in health and disease
In humans, circadian rhythm regulates the expression of numerous protein-coding genes across nearly all cell types, playin...
Conditioned medium from human adipose-derived mesenchymal stromal cells can modulate cell migration and morphology of keratinocytes in vitro
Conditioned medium from human adipose-derived mesenchymal stromal cells can modulate cell migration and morphology of keratinocytes in vitro
The regenerative ability of the skin is orchestrated by different types of cells, including mesenchymal stromal cells (MSC...
SIRT1 reduced DDX5 neddylation to attenuate myocardial ischemia/reperfusion injury
SIRT1 reduced DDX5 neddylation to attenuate myocardial ischemia/reperfusion injury
SIRT1 exhibited a protective role in myocardial ischemia/reperfusion injury (MI/RI), but the related mechanisms remained u...
The role of macrophages in peritoneal dialysis-associated peritoneal fibrosis
The role of macrophages in peritoneal dialysis-associated peritoneal fibrosis
The peritoneum is the largest and most complex serous membrane in the body belonging to the category of semi-permeable mem...
Establishment and characterization of a novel sinonasal adenosquamous carcinoma cell line, TC717, with a high tumor mutational burden
Establishment and characterization of a novel sinonasal adenosquamous carcinoma cell line, TC717, with a high tumor mutational burden
We established and characterized a novel human sinonasal adenosquamous carcinoma (ASC) cell line, TC717, derived from a 64...
5-Azacytidine induces sensory hair cell marker expression in human inner ear cells
5-Azacytidine induces sensory hair cell marker expression in human inner ear cells
Adult human inner ear hair cells have extremely limited regenerative ability, and the inaccessibility of human inner ear t...
MKRN2 enhances hepatocellular carcinoma proliferation through the p38 MAPK pathway
MKRN2 enhances hepatocellular carcinoma proliferation through the p38 MAPK pathway
Elucidating the molecular mechanisms underlying hepatocellular carcinoma (HCC) pathogenesis is crucial for the development...
DKK1 exacerbates dental pulp inflammation: insights from RNA-sequencing analysis
DKK1 exacerbates dental pulp inflammation: insights from RNA-sequencing analysis
Dickkopf-related protein 1 (DKK1) has been implicated in several inflammatory diseases; however, its role in pulpitis rema...
The sialyltransferase ST3GAL1 mediates MUCL1 sialylation to exacerbate breast cancer progression
The sialyltransferase ST3GAL1 mediates MUCL1 sialylation to exacerbate breast cancer progression
Breast cancer is highly heterogeneous and involves complex molecular mechanisms, posing significant therapeutic challenges...
Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway
Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway
Doxorubicin (DOX) is a commonly prescribed chemotherapeutic regimen, but its practice is challenged by cardiotoxicity risk...
Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone
Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a locally aggressive osteolytic bone tumor characterized by recurrent mutation in the H...
Femtosecond label-free imaging evaluates the metabolism of mesenchymal stromal cells
Femtosecond label-free imaging evaluates the metabolism of mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) hold significant promise in regenerative medicine, yet their clinical application is hind...
Unveiling TNFRSF19: a novel tumor suppressor targeting endoplasmic reticulum stress and LGR5/Wnt/β-catenin in cervical cancer
Unveiling TNFRSF19: a novel tumor suppressor targeting endoplasmic reticulum stress and LGR5/Wnt/β-catenin in cervical cancer
TNF Receptor Superfamily Member 19 (TNFRSF19) has been implicated in the advancement of several types of cancer. However, ...
Rolled amniotic membrane for practical vascular graft development: a scoping review
Rolled amniotic membrane for practical vascular graft development: a scoping review
Small-diameter vascular grafts remain a clinical challenge due to thrombosis, stenosis, and poor long-term patency of synt...
Establishment and characterization of a novel patient-derived -rearranged anaplastic large-cell lymphoma model PTCL-S1
Establishment and characterization of a novel patient-derived -rearranged anaplastic large-cell lymphoma model PTCL-S1
Anaplastic large-cell lymphoma (ALCL) accounts for 15% of all peripheral T-cell lymphomas globally and can be further divi...
Activated PLK1 promotes the migration and invasion of polyploid giant cancer cells with daughter cells via β-catenin/STAT3 signaling pathway
Activated PLK1 promotes the migration and invasion of polyploid giant cancer cells with daughter cells via β-catenin/STAT3 signaling pathway
The abundance of polyploid giant cancer cells (PGCCs) is correlated with malignant tumor progression. PGCCs divide asymmet...
Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis
Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis
Metastatic colorectal cancer is one of the most critical causes of cancer-related dead in patients suffering this type of ...
Palmatine inhibits colorectal cancer proliferation and metastasis by regulating miR-363-3p/AURKA axis
Palmatine inhibits colorectal cancer proliferation and metastasis by regulating miR-363-3p/AURKA axis
Colorectal cancer, a prevalent digestive system malignancy, is characterized by a high incidence, low early detection rate...
Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis
Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis
Diffuse large B-cell lymphoma (DLBCL) is a malignant tumor and research on its therapeutic targets has received increasing...
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and...
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by articular cartilage degeneration and synovial ...
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision re...
Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1
Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1
Cholangiocarcinoma (CCA) is a highly heterogeneous primary malignant tumor of the biliary tract. Intrahepatic and extrahep...
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Lung adenocarcinoma (LUAD) continues to be a major contributor to cancer-related deaths due to its aggressive nature and r...
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