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Establishment and characterization of a novel patient-derived -rearranged anaplastic large-cell lymphoma model PTCL-S1
Establishment and characterization of a novel patient-derived -rearranged anaplastic large-cell lymphoma model PTCL-S1
Anaplastic large-cell lymphoma (ALCL) accounts for 15% of all peripheral T-cell lymphomas globally and can be further divi...
Activated PLK1 promotes the migration and invasion of polyploid giant cancer cells with daughter cells via β-catenin/STAT3 signaling pathway
Activated PLK1 promotes the migration and invasion of polyploid giant cancer cells with daughter cells via β-catenin/STAT3 signaling pathway
The abundance of polyploid giant cancer cells (PGCCs) is correlated with malignant tumor progression. PGCCs divide asymmet...
Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis
Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis
Metastatic colorectal cancer is one of the most critical causes of cancer-related dead in patients suffering this type of ...
Palmatine inhibits colorectal cancer proliferation and metastasis by regulating miR-363-3p/AURKA axis
Palmatine inhibits colorectal cancer proliferation and metastasis by regulating miR-363-3p/AURKA axis
Colorectal cancer, a prevalent digestive system malignancy, is characterized by a high incidence, low early detection rate...
Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis
Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis
Diffuse large B-cell lymphoma (DLBCL) is a malignant tumor and research on its therapeutic targets has received increasing...
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and...
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by articular cartilage degeneration and synovial ...
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision re...
Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1
Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1
Cholangiocarcinoma (CCA) is a highly heterogeneous primary malignant tumor of the biliary tract. Intrahepatic and extrahep...
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Lung adenocarcinoma (LUAD) continues to be a major contributor to cancer-related deaths due to its aggressive nature and r...
The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma
The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma
Thyroid transcription factor-1 (TTF-1) is a lineage-specific marker for lung adenocarcinoma (LUAD), whereas the relatively...
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin has been reported to have increased expression w...
Collagen alpha-5(IV) chain activation by nuclear factor 1/C promotes nasopharyngeal carcinoma progression
Collagen alpha-5(IV) chain activation by nuclear factor 1/C promotes nasopharyngeal carcinoma progression
The expression of collagen receptors by cancer cells serves a vital function in the regulation of cell behavior. These rec...
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Most drug discovery studies use 2D cell cultures and animal models for screening new chemical entities (NCEs), which often...
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme, and a growing body...
Regulatory T cells in cancer anti-PD-(L)1 therapy
Regulatory T cells in cancer anti-PD-(L)1 therapy
Regulatory T cell (Treg) immunome profile and targets in antiprogrammed cell death-1 (PD-1)/programmed cell death-ligand 1...
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
Intestinal failure-associated liver disease (IFALD) is a life-threatening complication of short bowel syndrome (SBS), char...
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
miR-487a-3p shows the potential of modulating adipose-derived stem cells (ADSCs) differentiation. This study aimed to inve...
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare osteolytic tumor composed of mononuclear stromal cells, macrophages, and osteocl...
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
Resistance to cisplatin-based chemotherapy limits the clinical benefit to some bladder cancer patients, and understanding ...
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
Acute injury and secondary injury caused by traumatic brain injury (TBI) seriously threaten the health of patients. The pu...
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary malignant neoplasm exhibiting a high mortality rate. Taxifolin is a naturally ...
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its c...
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Imatinib resistance is a major obstacle to the successful treatment of gastrointestinal stromal tumors (GIST). Long non-co...
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with ora...
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique cas...
The dual role of PTPN22 in immune modulation and transplantation tolerance
The dual role of PTPN22 in immune modulation and transplantation tolerance
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, et al. Identification of substrates of human protein-tyrosine p...
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
Autophagy, a cellular degradation process involving the formation and clearance of autophagosomes, is mediated by autophag...
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
We previously examined the antitumor effects of short interfering RNA nanoparticles targeting mammalian target of rapamyci...
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health cha...
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