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Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare osteolytic tumor composed of mononuclear stromal cells, macrophages, and osteocl...
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
Resistance to cisplatin-based chemotherapy limits the clinical benefit to some bladder cancer patients, and understanding ...
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
Acute injury and secondary injury caused by traumatic brain injury (TBI) seriously threaten the health of patients. The pu...
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary malignant neoplasm exhibiting a high mortality rate. Taxifolin is a naturally ...
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its c...
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Imatinib resistance is a major obstacle to the successful treatment of gastrointestinal stromal tumors (GIST). Long non-co...
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with ora...
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique cas...
The dual role of PTPN22 in immune modulation and transplantation tolerance
The dual role of PTPN22 in immune modulation and transplantation tolerance
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, et al. Identification of substrates of human protein-tyrosine p...
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
Autophagy, a cellular degradation process involving the formation and clearance of autophagosomes, is mediated by autophag...
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
We previously examined the antitumor effects of short interfering RNA nanoparticles targeting mammalian target of rapamyci...
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health cha...
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke, and the neuroprotective effects of nimodipine following SAH...
Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa
Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa
Human cancer cell lines have an essential role in cancer research, but only authentic cell lines should be used as biologi...
Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model
Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model
Solitary fibrous tumor/Hemangiopericytoma (SFT/HPC) is a rare subtype of soft tissue sarcoma harboring NAB2–STAT6 ge...
Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach
Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach
Type 2 Diabetes Mellitus (T2DM) accounts for more than 90% of total diabetes mellitus cases all over the world. Obesity an...
Delivery of microRNA-423-5p by exosome from adipose-derived stem/stromal cells inhibits DVL3 to potentiate autologous fat graft survival through adipogenesis and inflammatory response
Delivery of microRNA-423-5p by exosome from adipose-derived stem/stromal cells inhibits DVL3 to potentiate autologous fat graft survival through adipogenesis and inflammatory response
Autologous fat grafting represents a reconstructive technique but is limited by unstable graft retention. Based on existin...
Cell replacement therapy with stem cells in multiple sclerosis, a systematic review
Cell replacement therapy with stem cells in multiple sclerosis, a systematic review
Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system...
Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression
Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression
Nucleoporin 93 (NUP93) is an important component of the nuclear pore complex, exhibiting pro-tumorigenic properties in som...
LINC00941: a novel player involved in the progression of human cancers
LINC00941: a novel player involved in the progression of human cancers
LINC00941, also known as lncRNA-MUF, is an intergenic non-coding RNA located on chromosome 12p11.21. It actively participa...
Estrogen receptor- and progesterone receptor-positive breast tumors have higher mRNA levels of NR3C1 and ZBTB16, with implications in prognosis for luminal A subtype
Estrogen receptor- and progesterone receptor-positive breast tumors have higher mRNA levels of NR3C1 and ZBTB16, with implications in prognosis for luminal A subtype
Prekovic S, Chalkiadakis T, Roest M, Roden D, Lutz C, Schuurman K, Opdam M, Hoekman L, Abbott N, Tesselaar T, Wajahat M, D...
Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke
Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke
Promising preclinical stroke research has not yielded meaningful and significant success in clinical trials. This lack of ...
Human dental pulp stem cells have comparable abilities to umbilical cord mesenchymal stem/stromal cells in regulating inflammation and ameliorating hepatic fibrosis
Human dental pulp stem cells have comparable abilities to umbilical cord mesenchymal stem/stromal cells in regulating inflammation and ameliorating hepatic fibrosis
Hepatic fibrosis, also called cirrhosis, have wide prevalence worldwide for long yeas. Recently, many treatments for liver...
Establishment and characterization of a novel hilar cholangiocarcinoma cell line, CBC3T-1
Establishment and characterization of a novel hilar cholangiocarcinoma cell line, CBC3T-1
Cholangiocarcinoma (CCA) is a group of malignant heterogeneous cancer arising from the biliary tree. The tumor is characte...
Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue
Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue
Pulmonary arterial hypertension (PAH) is a chronic disease thatultimately progresses to right-sided heart failure and deat...
CTLA-4 and ovarian cancer residual tumors: the dark side of debulking surgery
CTLA-4 and ovarian cancer residual tumors: the dark side of debulking surgery
Conflict of interest The authors declare that they have no ...
The interferon-stimulated genes are plausibly a primary genetic locus for genetically enabling hyperinflammatory and autoimmune diseases and lymphocyte exhaustion
The interferon-stimulated genes are plausibly a primary genetic locus for genetically enabling hyperinflammatory and autoimmune diseases and lymphocyte exhaustion
Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, Xu Y, Tian Z. Functional exhaustion of antiviral lymphocytes in COVID-19 pat...
Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target
Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target
Receptor tyrosine kinases (RTKs) serve as molecular targets for the development of novel personalized therapies in many ma...
Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights
Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights
According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of g...
Establishment and characterization of a recurrent malignant peripheral nerve sheath tumor cell line: RsNF
Establishment and characterization of a recurrent malignant peripheral nerve sheath tumor cell line: RsNF
Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive and recurrent soft tissue sarcoma. It most commonly...
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