Yuan Q, Chen R, Zheng X, Meng M, Kao Y, Liu J, et al. Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway. Mol Med Rep. 2017;16(2):1551–8.

Article  CAS  PubMed  Google Scholar 

Wu C, Chen Y, Wang Y, Xu C, Cai Y, Zhang R, et al. The m6A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway. Mol Cell Biochem. 2024;479(6):1391–400.

Article  CAS  PubMed  Google Scholar 

Katsumata Y, Shinmura K, Sugiura Y, Tohyama S, Matsuhashi T, Ito H, et al. Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. Hypertension. 2014;63(1):80–7.

Article  CAS  PubMed  Google Scholar 

Wang L, Qi H, Tang Y, Shen HM. Post-translational modifications of key machinery in the control of mitophagy. Trends Biochem Sci. 2020;45(1):58–75.

Article  PubMed  Google Scholar 

Liu X, Ge J, Chen C, Shen Y, Xie J, Zhu X, et al. FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4–2/Nav15 complex formation. Cell Death Disease. 2021;12(1):25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Enchev RI, Schulman BA, Peter M. Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol. 2015;16(1):30–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hjerpe R, Thomas Y, Kurz T. NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway. J Mol Biol. 2012;421(1):27–9.

Article  CAS  PubMed  Google Scholar 

Rabut G, Peter M. Function and regulation of protein neddylation. EMBO Rep. 2008;9(10):969–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lz A, Wz B, Ysc D, Lj A. Protein neddylation and its alterations in human cancers for targeted therapy. Cell Signal. 2018;44:92–102.

Article  Google Scholar 

Zhou L, Jiang Y, Luo Q, Li L, Jia L. Neddylation: a novel modulator of the tumor microenvironment. Mol Cancer. 2019;18(1):77.

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Morgan MA, Sun Y. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal. 2014;21(17):2383–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, et al. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010;122(21):2170–82.

Article  PubMed  PubMed Central  Google Scholar 

Andérica-Romero AC, Hernández-Damián J, Vázquez-Cervantes GI, Torres I, Pedraza-Chaverri J. The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation. Redox Biol. 2016;8:341–7.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Cui J, Zhao F, Yang L, Xu X, Shi Y, et al. Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1. Redox Biol. 2021;46:102114. https://doi.org/10.1016/j.redox.2021.102114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leng S, Huang W, Chen Y, Yang Y, Feng D, Liu W, et al. SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. Cell Death Differ. 2021;28(12):3329–43. https://doi.org/10.1038/s41418-021-00821-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jia K, Cheng H, Ma W, Zhuang L, Li H, Li Z, et al. RNA helicase DDX5 maintains cardiac function by regulating CamkIIδ alternative splicing. Circulation. 2024;150(14):1121–39.

Article  CAS  PubMed  Google Scholar 

Chang L, Chai X, Chen P, Cao J, Xie H, Zhu J. miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5. Int J Mol Med. 2019;43(1):143–54.

CAS  PubMed  Google Scholar 

Kim JS, Choi J, Shin MS, Kim M, Seo EJ, An M, et al. Do advance directive attitudes and perceived susceptibility and end-of-life life-sustaining treatment preferences between patients with heart failure and cancer differ? PLoS ONE. 2020;15(9):e0238567.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nedvedova I, Kolar D, Neckar J, Kalous M, Pravenec M, Šilhavý J, et al. Cardioprotective regimen of adaptation to chronic hypoxia diversely alters myocardial gene expression in SHR and SHR-mtBN Conplastic Rat Strains. Front Endocrinol. 2019;22:809. https://doi.org/10.3389/fendo.2018.00809.

Article  Google Scholar 

Xie P, Peng Z, Chen Y, Li H, Zhang L. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Cell Res. 2020;31(3):291–311.

Article  PubMed  PubMed Central  Google Scholar 

Asa B, Kkc D. SIRT1: Regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356–60.

Article  Google Scholar 

Soni SK, Basu P, Singaravel M, Sharma R, Reiter RJ. Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1. Cell Mol Life Sci. 2021;78(6):2503–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Y, Cui H, Zhang Y, Yu P, Li Y, Wu D, et al. W Fu Inonotusobliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress. Mole Med Rep. 2021;23(1):1.

Google Scholar 

Kane AE, Sinclair DA. Sirtuins and NAD(+) in the development and treatment of metabolic and cardiovascular diseases. Circ Res A J Am Heart Assoc. 2018;123(7):868–85.

CAS  Google Scholar 

Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, et al. A role for the NAD-dependent deacetylase Sirti in the regulation of autophagy. Proc Nat Acad Sci USA. 2008;105(9):3374–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan SH, Hung CH, Shih JY, Chu PM, Cheng YH, Lin HC, et al. SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease. Redox Biol. 2017;13:301–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rookyard AW, Paulech J, Thyssen S, Liddy KA, Puckeridge M, Li DK, et al. A global profile of reversible and irreversible cysteine redox post-translational modifications during myocardial ischemia/reperfusion injury and antioxidant intervention. Antioxid Redox Signal. 2021;34(1):11–31. https://doi.org/10.1089/ars.2019.7765.

Article  CAS  PubMed  Google Scholar 

Gao J, Shao K, Chen X, Li Z, Liu Z, Yu Z, et al. The involvement of post-translational modifications in cardiovascular pathologies: focus on SUMOylation, neddylation, succinylation, and prenylation. J Mol Cell Cardiol. 2020;138:49–58. https://doi.org/10.1016/j.yjmcc.2019.11.146.

Article  CAS  PubMed  Google Scholar 

Barghout SH, Schimmer AD. E1 enzymes as therapeutic targets in cancer. Pharmacol Rev. 2020;73(1):1–58.

Article  Google Scholar 

Shukla M, Chinchalongporn V, Govitrapong P. Melatonin prevents neddylation dysfunction in Aβ42-Exposed SH-SY5Y neuroblastoma cells by regulating the amyloid precursor protein- binding protein 1 pathway. Curr Alzheimer Res. 2020;17(5):446–59.

Article  CAS  PubMed  Google Scholar 

Kamitani T, Kito K, Nguyen HP, Yeh ETH. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem. 1997;272(45):28557–62.

Article