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GREM1 signaling in cancer: tumor promotor and suppressor?
GREM1 signaling in cancer: tumor promotor and suppressor?
GREMLIN1 (GREM1) is member of a family of structurally and functionally related secreted cysteine knot proteins, which act...
Farewell Springer… Hello Wiley
Farewell Springer… Hello Wiley
Academic publishing is the support for dissemination of research findings that constitute the grounds upon which new orien...
miRNAs as short non-coding RNAs in regulating doxorubicin resistance
miRNAs as short non-coding RNAs in regulating doxorubicin resistance
The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disru...
Use and application of organ-on-a-chip platforms in cancer research
Use and application of organ-on-a-chip platforms in cancer research
Tumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Ex...
Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
Mesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs posse...
GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes r...
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer
Aberrant canonical Wnt signaling is a hallmark of colon cancer. The TP53 tumor suppressor gene is altered in many solid tu...
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
Drug resistance represents a major problem in cancer treatment. Doxorubicin (adriamycin) is an injectable DNA intercalatin...
Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases
Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts that are longer than 200 nucleotides in length. LncRNAs ...
Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
Interleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses ...
Exosomal miR-129 and miR-342 derived from intermittent hypoxia-stimulated vascular smooth muscle cells inhibit the eIF2α/ATF4 axis from preventing calcified aortic valvular disease
Exosomal miR-129 and miR-342 derived from intermittent hypoxia-stimulated vascular smooth muscle cells inhibit the eIF2α/ATF4 axis from preventing calcified aortic valvular disease
This study aims to elucidate the role of miR-129/miR-342 loaded in exosomes derived from vascular smooth muscle cells (VSM...
Dual RNase activity of IRE1 as a target for anticancer therapies
Dual RNase activity of IRE1 as a target for anticancer therapies
The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is...
Expression and function of CCN2-derived circRNAs in chondrocytes
Expression and function of CCN2-derived circRNAs in chondrocytes
Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regener...
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling ...
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
Latroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and relea...
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells
An increasing number of studies have documented atypical protein kinase C isoform ι (PKCι) as an oncoprotein pla...
Role of EGFR and FASN in breast cancer progression
Role of EGFR and FASN in breast cancer progression
Breast cancer (BC) emerged as one of the life-threatening diseases among females. Despite notable improvements made in can...
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths. The five-year relative survival rate for ...
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
G protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular carcinoma ...
The advance of CCN3 in fibrosis
The advance of CCN3 in fibrosis
The extracellular matrix (ECM) is comprised of various extracellular macromolecules, including collagen, enzymes, and glyc...
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells
Enteroaggregative Escherichia coli (EAEC) is an emerging enteric pathogen associated with persistent dia...
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals
Liver fibrosis is an aberrant wound healing response to tissue injury characterized by excessive extracellular matrix depo...
Retraction Note: Long non-coding RNA TP73-AS1 promotes TFAP2B-mediated proliferation, metastasis and invasion in retinoblastoma via decoying of miRNA-874-3p
Retraction Note: Long non-coding RNA TP73-AS1 promotes TFAP2B-mediated proliferation, metastasis and invasion in retinoblastoma via decoying of miRNA-874-3p
Cite this articleWang, L., Wang, C., Wu, T. et al. Retraction Note: Long non-coding RNA TP73-AS1 promotes TFAP2B-mediated ...
Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers
Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers
Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for canc...
The antitumor effects of WNT5A against hematological malignancies
The antitumor effects of WNT5A against hematological malignancies
The bone marrow (BM) microenvironment (niche) is abnormally altered in acute myeloid leukemia (AML), leading to deficient ...
CCNs and other extracellular matrix proteins: an introduction to the special issue
CCNs and other extracellular matrix proteins: an introduction to the special issue
The extracellular matrix (ECM) is a specialized, highly organized and dynamic three-d...
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis
Studies have shown that tripartite motif–containing (TRIM) family proteins function as E3 ubiquitin ligases and play...
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins) family of proteins consists of six ex...
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
Skin primarily comprises a collagen-rich extracellular matrix (ECM) that provides structural and functional support to the...
Structural insights into regulation of CCN protein activities and functions
Structural insights into regulation of CCN protein activities and functions
CCN proteins play important functions during development, in repair mechanisms following tissue injury, as well as in path...
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