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A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures
Human peri-gastrulation is a critical developmental stage, yet challenging to study directly. Stem cell-based embryo model...
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
The endoplasmic reticulum (ER) requires an oxidative environment to support the efficient maturation of secretory and memb...
A lipid-centric view of endocytosis by caveolae
A lipid-centric view of endocytosis by caveolae
Caveolae have long been considered to be an alternative endocytic pathway, with distinct cargoes, but generally similar fu...
The proteomic landscape and temporal dynamics of human and mouse gastruloid development
The proteomic landscape and temporal dynamics of human and mouse gastruloid development
The embryo establishes a body plan and primes itself for organogenesis during gastrulation. As gastrulation is challenging...
Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability
Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selective...
Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour
Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour
Leukaemic stem cells (LSCs) reside in protective bone marrow (BM) niches that promote therapeutic resistance and relapse. ...
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing
Pancreatic ductal adenocarcinomas (PDACs) are aggressive, stroma-rich tumours. They are unresponsive to treatments, and pa...
Somatic mutations distinguish melanocyte subpopulations in human skin
Somatic mutations distinguish melanocyte subpopulations in human skin
Here, to understand the homeostatic mechanisms governing melanocytes, we interrogate the mutational landscapes, gene-expre...
Fusion oncoproteins acquire condensate propensity to initiate tumour formation
Fusion oncoproteins acquire condensate propensity to initiate tumour formation
Gene fusions are potent drivers of cancer, and nuclear condensates are known to have a role in transcription. By creating ...
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection
The ataxia telangiectasia mutated (ATM) kinase orchestrates the early stages of DNA double-strand break repair by promotin...
RNA-binding proteins pull in chromatin loops
RNA-binding proteins pull in chromatin loops
During development as cells exit a pluripotent state, chromatin looping interactions are strengthened, but the mechanism f...
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
Topologically associating domains (TADs) and chromatin architectural loops impact promoter–enhancer interactions, wi...
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
In mammals, chromosome-wide regulatory mechanisms ensure a balance of X-linked gene dosage between males (XY) and females ...
CD160+CD8+ T cells for improved immunotherapy
CD160+CD8+ T cells for improved immunotherapy
A study now indicates that CD160⁺CD8⁺ T cells in patients with colorectal cancer modulate anti-tumour immune r...
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer
The colon exhibits higher propensity for tumour development than ileum. However, the role of immune microenvironment diffe...
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despit...
Tripotency in human pancreas
Research in the mouse indicates that all three pancreas epithelial compartments derive from a single and transient progeni...
Chaperoning RNA into granules
Biomolecular condensate formation requires multivalent interactions and rapid turnover. Stress granules are condensates fo...
Real-time mirroring of therapy
Early assessment of treatment efficacy can be invaluable in cases of aggressive tumours, such as glioblastoma. Logun et al...
Battling Diamond-Blackfan anaemia
Gene therapy strategies against Diamond-Blackfan anaemia (DBA) have been hampered by the multiple and heterogeneous causat...
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Adapting to improve the author experience
Here we discuss approaches to refine our editorial processes.
Mitochondrial protein import stress
Mitochondrial protein import stress
Mitochondria have to import a large number of precursor proteins from the cytosol. Chaperones keep these proteins in a lar...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Gene expression is regulated by multiple epigenetic mechanisms, which are coordinated in development and disease. However,...
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