Porter, K. R., Claude, A. & Fullam, E. F. A study of tissue culture cells by electron microscopy. J. Exp. Med. 81, 233–246 (1945).
Article CAS PubMed PubMed Central Google Scholar
Palade, G. Intracellular aspects of the process of protein synthesis. Science 189, 347–358 (1975).
Article CAS PubMed Google Scholar
Csala, M., Bánhegyi, G. & Benedetti, A. Endoplasmic reticulum: a metabolic compartment. FEBS Lett. 580, 2160–2165 (2006).
Article CAS PubMed Google Scholar
Csala, M. et al. Transport and transporters in the endoplasmic reticulum. Biochim. Biophys. Acta 1768, 1325–1341 (2007).
Article CAS PubMed Google Scholar
Jacquemyn, J., Cascalho, A. & Goodchild, R. E. The ins and outs of endoplasmic reticulum-controlled lipid biosynthesis. EMBO Rep. 18, 1905–1921 (2017).
Article CAS PubMed PubMed Central Google Scholar
Walter, P. & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334, 1081–1086 (2011).
Article CAS PubMed Google Scholar
Merksamer, P. I., Trusina, A. & Papa, F. R. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 135, 933–947 (2008).
Article CAS PubMed PubMed Central Google Scholar
Acosta-Alvear, D., Harnoss, J. M., Walter, P. & Ashkenazi, A. Homeostasis control in health and disease by the unfolded protein response. Nat. Rev. Mol. Cell Biol. 26, 193–212 (2025).
Article CAS PubMed Google Scholar
Montero, D., Tachibana, C., Rahr Winther, J. & Appenzeller-Herzog, C. Intracellular glutathione pools are heterogeneously concentrated. Redox Biol. 1, 508–513 (2013).
Article CAS PubMed PubMed Central Google Scholar
Hwang, C., Sinskey, A. J. & Lodish, H. F. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257, 1496–1502 (1992).
Article CAS PubMed Google Scholar
Birk, J. et al. Endoplasmic reticulum: reduced and oxidized glutathione revisited. J. Cell Sci. 126, 1604–1617 (2013).
Piccirella, S. et al. Uncoupled redox systems in the lumen of the endoplasmic reticulum. J. Biol. Chem. 281, 4671–4677 (2006).
Article CAS PubMed Google Scholar
Chen, W. W., Freinkman, E., Wang, T., Birsoy, K. & Sabatini, D. M. Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166, 1324–1337.e11 (2016).
Article CAS PubMed PubMed Central Google Scholar
Abu-Remaileh, M. et al. Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. Science 358, 807–813 (2017).
Article CAS PubMed PubMed Central Google Scholar
Fasimoye, R. et al. Golgi-IP, a tool for multimodal analysis of Golgi molecular content. Proc. Natl Acad. Sci. USA 120, e2219953120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Itzhak, D. N., Tyanova, S., Cox, J. & Borner, G. H. Global, quantitative and dynamic mapping of protein subcellular localization. eLife 5, e16950 (2016).
Article PubMed PubMed Central Google Scholar
Hein, M. Y. et al. Global organelle profiling reveals subcellular localization and remodeling at proteome scale. Cell 188, 1137–1155 (2024).
Aebi, M. N-linked protein glycosylation in the ER. Biochim. Biophys. Acta 1833, 2430–2437 (2013).
Article CAS PubMed Google Scholar
Gerin, I., Veiga-da-Cunha, M., Achouri, Y., Collet, J. F. & Van Schaftingen, E. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. FEBS Lett. 419, 235–238 (1997).
Article CAS PubMed Google Scholar
Martin, C. C. et al. Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. J. Mol. Endocrinol. 29, 205–222 (2002).
Article CAS PubMed Google Scholar
Clarke, J. L. & Mason, P. J. Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity. Arch. Biochem. Biophys. 415, 229–234 (2003).
Article CAS PubMed Google Scholar
van Meer, G., Voelker, D. R. & Feigenson, G. W. Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 9, 112–124 (2008).
Article PubMed PubMed Central Google Scholar
Kim, W. et al. Polyunsaturated fatty acid desaturation is a mechanism for glycolytic NAD+ recycling. Cell Metab. 29, 856–870 (2019).
Article CAS PubMed PubMed Central Google Scholar
Wang, Y. et al. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature 599, 136–140 (2021).
Article CAS PubMed PubMed Central Google Scholar
Kanamori, A. et al. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter. Proc. Natl Acad. Sci. USA 94, 2897–2902 (1997).
Article CAS PubMed PubMed Central Google Scholar
DeNicola, G. M. et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47, 1475–1481 (2015).
Article CAS PubMed PubMed Central Google Scholar
Poet, G. J. et al. Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER. EMBO J. 36, 693–702 (2017).
Article CAS PubMed PubMed Central Google Scholar
Cao, X. et al. The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins. J. Cell Sci. 133, jcs241976 (2020).
Article CAS PubMed PubMed Central Google Scholar
Bloch, J. S. et al. Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc. Natl Acad. Sci. USA 118, e2115435118 (2021).
Article CAS PubMed PubMed Central Google Scholar
Piper, S. J., Johnson, R. M., Wootten, D. & Sexton, P. M. Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using cryo-EM. Chem. Rev. 122, 13989–14017 (2022).
Article CAS PubMed PubMed Central Google Scholar
Wentinck, K., Gogou, C. & Meijer, D. H. Putting on molecular weight: enabling cryo-EM structure determination of sub-100-kDa proteins. Curr. Res. Struct. Biol. 4, 332–337 (2022).
Comments (0)