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Prediction of structural variation
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Protein language models for predicting drug–target interactions: Novel approaches, emerging methods, and future directions
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Modeling Boltzmann-weighted structural ensembles of proteins using artificial intelligence–based methods
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From part to whole: AI-driven progress in fragment-based drug discovery
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Deep learning for RNA structure prediction
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Chromatin domains in the cell: Phase separation and condensation
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Editorial overview: Catalysis and regulation (2024): Conformational dynamics of RNA and kinase signaling
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A structural perspective on enzymes and their catalytic mechanisms
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Deciphering driving forces of biomolecular phase separation from simulations
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Recent advances in AI-driven protein-ligand interaction predictions
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Machine learning methods to study sequence–ensemble–function relationships in disordered proteins
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Leveraging protein structural information to improve variant effect prediction
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Language models for protein design
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Allosteric modulation of protein–protein interactions in signal transduction with Nanobodies
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Rational design of cyclic peptides, with an emphasis on bicyclic peptides
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Super-resolving chromatin in its own terms: Recent approaches to portray genomic organization
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Structural insights into the recognition of native nucleosomes by pioneer transcription factors
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Mechanistic insights into INO80-type chromatin remodelers
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Atomistic molecular dynamics simulations of intrinsically disordered proteins
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Raman spectroscopy and imaging of protein droplet formation and aggregation
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How the ribosome shapes cotranslational protein folding
How the ribosome shapes cotranslational protein folding
During protein synthesis, the growing nascent peptide chain moves inside the polypeptide exit tunnel of the ribosome from ...
Regulation of tau by peptidyl-prolyl isomerases
Regulation of tau by peptidyl-prolyl isomerases
Tau is an intrinsically disordered protein found abundantly in axons, where it binds to microtubules. Since tau is a centr...
Commonly asked questions about transcriptional activation domains
Commonly asked questions about transcriptional activation domains
KeywordsTranscriptionTranscription factorCoactivatorRNA polymerase IIActivation domainTransactivation domainTranscriptiona...
Integrative approaches for characterizing protein dynamics: NMR, CryoEM, and computer simulations
Integrative approaches for characterizing protein dynamics: NMR, CryoEM, and computer simulations
Proteins are the major components of the molecular machinery that keep cells and organisms alive, performing their tasks i...
Understanding the heterogeneity intrinsic to protein folding
Understanding the heterogeneity intrinsic to protein folding
Volume 84, February 2024, 102738Author links open overlay panel, AbstractRelating the native fold of a protein to its amin...
Dynamics and interactions of intrinsically disordered proteins
Dynamics and interactions of intrinsically disordered proteins
It has been 25 years since the concept of intrinsically disordered proteins (IDPs) was proposed [1]. IDPs with intrinsical...
Cryo-electron ptychography: Applications and potential in biological characterisation
Cryo-electron ptychography: Applications and potential in biological characterisation
There is a clear need for developments in characterisation techniques that provide detailed information about structure–fu...
Automated pipelines for rapid evaluation during cryoEM data acquisition
Automated pipelines for rapid evaluation during cryoEM data acquisition
In recent years, cryo-electron microscopy (cryoEM), especially single particle analysis, has experienced an increase in po...
Protein disaggregation machineries in the human cytosol
Protein disaggregation machineries in the human cytosol
The process of folding is a seminal event in the life of a protein, converting a newly synthesized polypeptide into the fu...
Artificial intelligence-driven antimicrobial peptide discovery
Artificial intelligence-driven antimicrobial peptide discovery
Antimicrobial resistance, fueled by antibiotic overuse that drives the emergence of resistant strains, is recognized as a ...
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