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MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleos...
T follicular regulatory cells keep B cell-directed autoreactivity in check
T follicular regulatory cells keep B cell-directed autoreactivity in check
The immune system well illustrates the need for balance between aggression and tolerance: mechanisms ...
Complement(ing) the microbiome in infants through breastmilk
Complement(ing) the microbiome in infants through breastmilk
Breastfeeding has a major impact on the health of infants. In a recent study published in Cell, Xu et...
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
We thank Xiaomin Li and Jianlin Lei for technical support during EM image acquisition. We thank the Tsinghua University Br...
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1)...
Treating insomnia with 40 Hz light flicker
A new study published in Cell Research reports that 40 Hz light flicker induces a somnogenic effect m...
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Neural signals can significantly influence cancer prognosis. However, how cancer cells may proactively modulate the nervou...
Metabolic engineering of the paclitaxel anticancer drug
Metabolic engineering of the paclitaxel anticancer drug
In a recently published Science article, Jiang et al. unraveled a couple of missing enzymes achieving...
Publisher Correction: Sanofi-Cell Research outstanding paper award of 2022
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Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Blockade of the PD-L1/PD-1 pathway in combination of IL-2 therapy appears to yield synergistic anti-t...
A precision counterstrike on central nervous system autoimmunity
A precision counterstrike on central nervous system autoimmunity
Autoantibodies targeting the N-methyl-D-aspartate receptor (NMDAR) induce debilitating neuropsychiatr...
Sanofi-Cell Research outstanding paper award of 2022
Sanofi-Cell Research outstanding paper award of 2022
We are pleased to announce the winners of the 2022 Sanofi-Cell Research Outstanding Research Article ...
Rpd3S meets the nucleosome
Rpd3S meets the nucleosome
Two recent reports in Cell Research present cryo-electron microscopy structures of the Rpd3S HDAC com...
Flooding plant apoplast through water and solute channels
Flooding plant apoplast through water and solute channels
Inducing water-soaking symptoms is a key early step during the pathogenesis of many fungal, oomycete,...
Decoding Golgiphagy: selective recycling under stress
Decoding Golgiphagy: selective recycling under stress
In a recent study, Hickey et al. use quantitative proteomics to show that ER-phagy and Golgiphagy are...
Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex
Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex
We thank the Cryo-EM Center at University of Science and Technology of China for the support of cryo-EM data collection. T...
Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes
Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes
RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive ...
Human SIDT1 mediates dsRNA uptake via its phospholipase activity
Human SIDT1 mediates dsRNA uptake via its phospholipase activity
Author notesThese authors contributed equally: Cai-Rong Sun, Da Xu, Fengrui Yang.Authors and AffiliationsSchool of Life Sc...
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity
In the nematode Caenorhabditis elegans, the systemic RNA interference defective protein 1 (SID-1) plays a...
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The u...
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a totipotent embryo, which gives rise to ...
Time and place: mapping human prenatal macrophages across tissues
Time and place: mapping human prenatal macrophages across tissues
In a recent Cell paper, Wang et al. characterized human immune cells at the single-cell level across 19 t...
Hematopoietic memory of severe COVID-19 infection
Hematopoietic memory of severe COVID-19 infection
A new study describes that individuals who recovered from severe coronavirus disease-19 (COVID-19) exhibi...
SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion
SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion
Reported recently in Cell , Chen et al. identify a novel membrane-ba...
An idle PHGDH takes control of cell fate
An idle PHGDH takes control of cell fate
Multifunctional metabolites are widely involved in physiological and pathological processes as signaling ...
Humanizing pig kidneys via chimeric complementation
Humanizing pig kidneys via chimeric complementation
An ultimate goal in stem cell research is to use induced pluripotent stem cells (iPSCs) to generate trans...
Structural basis for activation and filamentation of glutaminase
Structural basis for activation and filamentation of glutaminase
Glutaminase catalyzes the first step of glutamine metabolism, converting glutamine to glutamate, which en...
Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme
Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme
Histone deacetylases (HDACs) are evolutionally conserved enzymes that remove acetyl modifications from hi...
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states b...
Learning human liver biology in humanized mice
Learning human liver biology in humanized mice
A new study describes development of a chimeric mouse liver repopulated with nearly all human hepatic cel...
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