Xiao Fan

Present address: Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, USA

These authors contributed equally: Xiao Fan, Jiaofeng Chen.

Department of Molecular Biology, Princeton University, Princeton, NJ, USA

Xiao Fan

Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

Jiaofeng Chen & Nieng Yan

Institute of Bio-Architecture and Bio-Interactions (IBABI), Shenzhen Medical Academy of Research and Translation, Guangming District, Shenzhen, Guangdong, China

Xiaoshuang Huang, Yuzhen Xie, Nieng Yan & Jian Huang

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China

Zhanfeng Hou & Zigang Li

Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China

Zigang Li

Institute of Chemical Biology, Shenzhen Bay Laboratory, Guangming District, Shenzhen, Guangdong, China

Nieng Yan

N.Y., J.H. and X.F. conceived the project. X.F., J.C., X.H., Z.H., Y.X., Z.L., N.Y. and J.H. designed experiments; X.F. and J.H. performed all experiments related to cryo-EM studies, including protein expression and purification; Z.H. conducted experiments related to peptide toxin synthesis; X.H. and Y.X. prepared clones for electrophysiology; J.C. carried out experiments related to electrophysiology; X.F., J.C., X.H., Z.H., Y.X., Z.L., N.Y. and J.H. analyzed data; X.F., J.H. and N.Y. wrote the manuscript with input from all authors. All authors approved the final manuscript.

Correspondence to Nieng Yan or Jian Huang.