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MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
This study demonstrates the effect of the rhodocyanine derivative MKT-077 on the function of isolated mitochondria from mo...
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a multifactorial disorder, with a high socioeconomic impact, characterized by chronic ab...
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
The work is devoted to the mathematical modeling of the regulation of electron and proton transport in the thylakoid membr...
Kinetic Characteristics of Erythrocyte Membrane Acetylcholinesterase in Ground Squirrels During Hibernation and Arousal
Kinetic Characteristics of Erythrocyte Membrane Acetylcholinesterase in Ground Squirrels During Hibernation and Arousal
Hibernation of small mammals is unique in that it consists of bouts—alternating periods of deep hibernation and inte...
Receptor Histidine Kinases in Green Algae: Domain Analysis
Receptor Histidine Kinases in Green Algae: Domain Analysis
In bacteria and some eukaryotes, an important tool to respond to both external and internal signals is a two-component sys...
PCMM Nanomaterials as Multifunctional Bioprobes Studied in Animal Model of
PCMM Nanomaterials as Multifunctional Bioprobes Studied in Animal Model of
Multifunctional nanomaterials which are active in the near infrared (NIR) region and can be physically guided (laser light...
Tardigrade Dsup Protein Protects Human Cells during Proton Radiotherapy
Tardigrade Dsup Protein Protects Human Cells during Proton Radiotherapy
Principles of resistance to physicochemical stresses in extremophile organisms are unique for the development of new prote...
Network Pharmacology and Molecular Docking Analysis of Luteolin from for Drug Target Identification in Age-Related Cardiovascular Diseases
Network Pharmacology and Molecular Docking Analysis of Luteolin from for Drug Target Identification in Age-Related Cardiovascular Diseases
Aging is associated with an increased risk of cardiovascular diseases (CVDs), which are among the leading causes of mortal...
Expression and Purification of Transmembrane Domain of Insulin Receptors for Structural-Dynamic NMR Studies
Expression and Purification of Transmembrane Domain of Insulin Receptors for Structural-Dynamic NMR Studies
Members of the insulin receptor family (InsR, IGF1R, and IRR) play a key role in metabolic regulation, yet the structural ...
Changes in Electrical Properties of Bilayer Lipid Membranes Induced by Colloidal Magnetite (FeO) Nanoparticles in a Static Inhomogeneous Magnetic Field
Changes in Electrical Properties of Bilayer Lipid Membranes Induced by Colloidal Magnetite (FeO) Nanoparticles in a Static Inhomogeneous Magnetic Field
The changes of electrical parameters of azolectin membranes in a static inhomogeneous magnetic field at the one-sided addi...
Effect of DHPR on Functional Properties, Energy, and Ca Metabolism of during Unloading
Effect of DHPR on Functional Properties, Energy, and Ca Metabolism of during Unloading
Dihydropyridine receptors (DHPR) participate in changes of the membrane potential during muscle unloading. We used nifedip...
Using Liposomes Loaded with Fluorescent Dyes to Evaluate the Membranolytic Kinetics of Modular Nanotransporters
Using Liposomes Loaded with Fluorescent Dyes to Evaluate the Membranolytic Kinetics of Modular Nanotransporters
Modular nanotransporters are a drug delivery system developed for targeted cancer treatment. Modular nanotransporters are ...
The IP3-Dependent Signaling Pathway Is Involved in the Regulation of Atrophic Processes in Skeletal Muscles during Their Unloading
The IP3-Dependent Signaling Pathway Is Involved in the Regulation of Atrophic Processes in Skeletal Muscles during Their Unloading
The hypothesis of the relationship between changes in the calcium throughput of dihydropyridine receptors (DHPR) and the a...
Transmembrane Domain of Wild Type Spike Protein from SARS-CoV-2: Cell-Free Expression and Fast Purification for Structural-Dynamic NMR Studies
Transmembrane Domain of Wild Type Spike Protein from SARS-CoV-2: Cell-Free Expression and Fast Purification for Structural-Dynamic NMR Studies
COVID-19 is a rapidly disseminating disease whose causative agent is severe acute respiratory syndrome coronavirus 2 (SARS...
Changes of the Structure and Permeability of Lipid Membranes Caused by Nanoparticles and Pulsed Electromagnetic Effects
Changes of the Structure and Permeability of Lipid Membranes Caused by Nanoparticles and Pulsed Electromagnetic Effects
Studies of structure and permeability changes of biological and biomimetic lipid membranes caused by natural and artificia...
Study of Complexation of AED Peptide and Lysine Based Dendrimer with HisArg Spacers
Study of Complexation of AED Peptide and Lysine Based Dendrimer with HisArg Spacers
This study explores the interaction of bioactive AED tripeptide molecules with new lysine-based dendrimer KHR containing s...
Analysis of T-Cell Immune Response and Cross-Immunogenicity of Epitopes
Analysis of T-Cell Immune Response and Cross-Immunogenicity of Epitopes
Whooping cough is a serious illness affecting young children. There are two main types of vaccines for whooping cough: cel...
Modeling the Structure of Myoglobin within the Abelian Higgs Model
Modeling the Structure of Myoglobin within the Abelian Higgs Model
The analysis of multi-atomic systems from the first principles is highly computationally intensive, therefore it requires ...
Modeling the Distribution Kinetics of Charged Drugs in Tumor Cells under Variable Electric Fields Gradients on Mitochondrial and Nuclear Membranes
Modeling the Distribution Kinetics of Charged Drugs in Tumor Cells under Variable Electric Fields Gradients on Mitochondrial and Nuclear Membranes
The distribution of charged cytostatics or photosensitizers (PS) in tumor cells (TC) is an important factor in anticancer ...
Biofilms of MDR (hvKp) Strains Can be Destroyed by Free Fatty Acids Interactions with Bacterial Cell Wall Membranes
Biofilms of MDR (hvKp) Strains Can be Destroyed by Free Fatty Acids Interactions with Bacterial Cell Wall Membranes
Hypervirulent mucoviscus Klebsiella pneumoniae (hvKp) is rapidly emerging as opportunistic pathogens that have a global im...
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Planar lipid bilayers are unique tools designed for modeling cell membranes and electrophysiological studies of ion channe...
Structure and Functions of the OTOP1 Proton Channel
Structure and Functions of the OTOP1 Proton Channel
OTOP1 belongs to the otopetrin family of membrane proteins that form proton channels in cells of diverse types. In mammals...
Role of Membrane H Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Role of Membrane H Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Illuminated giant cells of Characeae produce alternating areas with H+-pump activity and zones of high H+/OH– conduc...
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Neurodegenerative diseases, along with cardiovascular and oncological pathologies, are one of the most acute problems of m...
Influence of Membrane Curvature on the Energy Barrier of Pore Formation
Influence of Membrane Curvature on the Energy Barrier of Pore Formation
Formation of through conducting defects—pores—in the lipid bilayer affects many processes in living cells and ...
Interaction of Albumin with Angiotensin-I-Converting Enzyme According to Molecular Modeling Data
Interaction of Albumin with Angiotensin-I-Converting Enzyme According to Molecular Modeling Data
Human serum albumin (HSA) is an endogenous inhibitor of angiotensin-I-converting enzyme (ACE), which is an integral membra...
Comparison of Spontaneous and Evoked Activity of CA1 Pyramidal Cells and Dentate Gyrus Granule Cells of the Hippocampus at an Increased Extracellular Potassium Concentration
Comparison of Spontaneous and Evoked Activity of CA1 Pyramidal Cells and Dentate Gyrus Granule Cells of the Hippocampus at an Increased Extracellular Potassium Concentration
In this work the effect of changing extracellular potassium concentration ([K+]o) on spontaneous and evoked burst activity...
Rapid Transfer of Photo-Released Protons from Water to Lipid Membrane
Rapid Transfer of Photo-Released Protons from Water to Lipid Membrane
The transport of protons between the membrane boundary and water can be hindered by the presence of a high potential barri...
Positive Effect of YB-1 and Mesenchymal Stromal Cells on Primary Hippocampal Culture under Conditions of ACE2 Receptor Blockade
Positive Effect of YB-1 and Mesenchymal Stromal Cells on Primary Hippocampal Culture under Conditions of ACE2 Receptor Blockade
Despite the fact that the current situation with COVID-19 incidence is not an emergency, new strains of SARS-CoV-2 coronav...
Cationic and Ionizable Amphiphiles Based on Dihexadecyl Ester of -Glutamic Acid for Liposomal Transport of RNA
Cationic and Ionizable Amphiphiles Based on Dihexadecyl Ester of -Glutamic Acid for Liposomal Transport of RNA
Various RNAs are among the most promising and actively developed therapeutic agents for the treatment of tumors, infectiou...
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