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Danicamtiv affected isometric force and cross-bridge kinetics similarly in skinned myocardial strips from male and female rats
Danicamtiv affected isometric force and cross-bridge kinetics similarly in skinned myocardial strips from male and female rats
Myotropes are pharmaceuticals that have recently been developed or are under investigation for the treatment of heart dise...
Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes
Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes
Pyruvate dehydrogenase kinase (PDK), which phosphorylates the pyruvate dehydrogenase complex, regulates glucose metabolism...
Biomechanical evaluation of flash-frozen and cryo-sectioned papillary muscle samples by using sinusoidal analysis: cross-bridge kinetics and the effect of partial Ca2+ activation
Biomechanical evaluation of flash-frozen and cryo-sectioned papillary muscle samples by using sinusoidal analysis: cross-bridge kinetics and the effect of partial Ca2+ activation
We examined the integrity of flash-frozen and cryo-sectioned cardiac muscle preparations (introduced by Feng and Jin, 2020...
Unraveling the bidirectional relationship between muscle inflammation and satellite cells activity: influencing factors and insights
Unraveling the bidirectional relationship between muscle inflammation and satellite cells activity: influencing factors and insights
Inflammation stands as a vital and innate function of the immune system, essential for maintaining physiological homeostas...
Muscle spindle receptors and their impact on Parkinson´s disease and Cerebral Palsy subjects
Muscle spindle receptors and their impact on Parkinson´s disease and Cerebral Palsy subjects
In some neurological conditions, like Parkinson’s disease (PD) and Cerebral Palsy (CP), as well as with ageing, musc...
Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin
Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin
Motor disorders are considered to originate mainly from brain lesions. Placental dysfunction or maternal exposure to a per...
Rbm24-mediated post-transcriptional regulation of skeletal and cardiac muscle development, function and regeneration
Rbm24-mediated post-transcriptional regulation of skeletal and cardiac muscle development, function and regeneration
RNA-binding proteins are critically involved in the post-transcriptional control of gene expression during embryonic devel...
Skeletal muscle of young females under resistance exercise exhibits a unique innate immune cell infiltration profile compared to males and elderly individuals
Skeletal muscle of young females under resistance exercise exhibits a unique innate immune cell infiltration profile compared to males and elderly individuals
Muscle damage resulting from physical activities such as exercise triggers an immune response crucial for tissue repair an...
Methylglyoxal reduces resistance exercise-induced protein synthesis and anabolic signaling in rat tibialis anterior muscle
Methylglyoxal reduces resistance exercise-induced protein synthesis and anabolic signaling in rat tibialis anterior muscle
Resistance exercise provides significant benefits to skeletal muscle, including hypertrophy and metabolic enhancements, su...
ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB
ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB
The muscular dystrophy with myositis (mdm) mouse model results in a severe muscular dystrophy due to an 83-amino-acid dele...
The effects of exercise and mitochondrial transplantation alone or in combination against Doxorubicin-induced skeletal muscle atrophy
The effects of exercise and mitochondrial transplantation alone or in combination against Doxorubicin-induced skeletal muscle atrophy
Doxorubicin (DOX) is a chemotherapy drug used to treat various types of cancer, but it is associated with significant side...
Four phases of a force transient emerge from a binary mechanical system
Four phases of a force transient emerge from a binary mechanical system
Accurate models of muscle contraction are important for understanding both muscle performance and the therapeutics that en...
TAM-associated CASQ1 mutants diminish intracellular Ca2+ content and interfere with regulation of SOCE
TAM-associated CASQ1 mutants diminish intracellular Ca2+ content and interfere with regulation of SOCE
Tubular aggregate myopathy (TAM) is a rare myopathy characterized by muscle weakness and myalgia. Muscle fibers from TAM p...
Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle
Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle
Eccentric contraction (ECC) has been shown to induce leukocyte invasion into skeletal muscle, resulting in muscle inflamma...
IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins
IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins
The proliferation and differentiation of skeletal muscle satellite cells is a complex physiological process involving vari...
Effects of membrane cholesterol-targeting chemicals on skeletal muscle contractions evoked by direct and indirect stimulation
Effects of membrane cholesterol-targeting chemicals on skeletal muscle contractions evoked by direct and indirect stimulation
Cholesterol is one of the major components of plasma membrane, where its distribution is nonhomogeneous and it participate...
Numb family proteins play roles in Desmin and Vimentin localization at the Z-disc
Numb family proteins play roles in Desmin and Vimentin localization at the Z-disc
Desmin and Vimentin are major intermediate filaments at the Z-disc and play significant roles in sarcomere architecture an...
The role of MEGF10 in myoblast fusion and hypertrophic response to overload of skeletal muscle
The role of MEGF10 in myoblast fusion and hypertrophic response to overload of skeletal muscle
Biallelic mutations in multiple EGF domain protein 10 (MEGF10) gene cause EMARDD (early myopathy, areflexia, respiratory d...
Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2: a mini-review
Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2: a mini-review
Skeletal muscle necrosis is a common clinical manifestation of snakebite envenoming. The predominant myotoxic components i...
The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis
The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis
This study aimed to explore the occurrence of necroptosis in skeletal muscle after eccentric exercise and investigate the ...
Protective effect of Luffa cylindrica Roemer against dexamethasone-induced muscle atrophy in primary rat skeletal muscle cells
Protective effect of Luffa cylindrica Roemer against dexamethasone-induced muscle atrophy in primary rat skeletal muscle cells
Glucocorticoids (GCs) are commonly used in the treatment of chronic inflammatory conditions. However, the administration o...
From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
Actin-myosin interactions form the basis of the force-producing contraction cycle within the sarcomere, serving as the pri...
John Squire: a leader and seminal contributor to experimental and theoretical muscle research for over 50 years
John Squire: a leader and seminal contributor to experimental and theoretical muscle research for over 50 years
This collection of papers aims to recognise and celebrate the life and scientific ach...
Correction: Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Correction: Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs
The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs
The Z-disk of striated muscle defines the ends of the sarcomere, which repeats many times within the muscle fiber. Here we...
Obituary: Professor John Michael Squire
Obituary: Professor John Michael Squire
In 1973 John joined Imperial College as lecturer in the Department of Metallurgy and Materials Science. This transition fr...
Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
Actin, tropomyosin and troponin, the proteins that comprise the contractile apparatus of the cardiac thin filament, are hi...
Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat
Challenging environmental conditions can drive the evolution of extreme physiological traits. The naked mole-rat has evolv...
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) leads to changes in the pump function of the heart and causes right-sided myocardial...
Molecular insights into titin’s A-band
Molecular insights into titin’s A-band
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important sc...
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