Agrawal A, Clayton EL, Cavazos CL, Clayton BA, Rodney GG (2025) Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome-lysosome fusion in dystrophin-deficient Mdx mice. Acta Physiol (Oxf) 241(1):e14243

Article  CAS  PubMed  Google Scholar 

Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS et al (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature 467(7312):218–222

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armstrong RB, Ogilvie RW, Schwane JA (1983) Eccentric exercise-induced injury to rat skeletal muscle. J Appl Physiol Respir Environ Exerc Physiol 54(1):80–93

CAS  PubMed  Google Scholar 

Balabanian L, Berger CL, Hendricks AG (2017) Acetylated microtubules are preferentially bundled leading to enhanced Kinesin-1 motility. Biophys J 113(7):1551–1560

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balnis J, Jackson EL, Drake LA, Singer DV, Bossardi Ramos R, Singer HA et al (2025) Rapamycin improves satellite cells’ autophagy and muscle regeneration during hypercapnia. JCI Insight. https://doi.org/10.1172/jci.insight.182842

Article  PubMed  PubMed Central  Google Scholar 

Cai D, McEwen DP, Martens JR, Meyhofer E, Verhey KJ (2009) Single molecule imaging reveals differences in microtubule track selection between kinesin motors. PLoS Biol 7(10):e1000216

Article  PubMed  PubMed Central  Google Scholar 

Call JA, Nichenko AS (2020) Autophagy: an essential but limited cellular process for timely skeletal muscle recovery from injury. Autophagy 16(7):1344–1347

Article  CAS  PubMed  PubMed Central  Google Scholar 

Call JA, Wilson RJ, Laker RC, Zhang M, Kundu M, Yan Z (2017) Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle. Am J Physiol Cell Physiol 312(6):C724–C32

Article  PubMed  PubMed Central  Google Scholar 

Cheung K, Hume P, Maxwell L (2003) Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med 33(2):145–164

Article  PubMed  Google Scholar 

Chu Y, Yuan X, Tao Y, Yang B, Luo J (2024) Autophagy in muscle regeneration: mechanisms, targets, and therapeutic perspective. Int J Mol Sci. https://doi.org/10.3390/ijms252211901

Article  PubMed  PubMed Central  Google Scholar 

Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, Humbert S et al (2007) Histone deacetylase 6 inhibition compensates for the transport deficit in huntington’s disease by increasing tubulin acetylation. J Neurosci 27(13):3571–3583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumont NA, Bentzinger CF, Sincennes MC, Rudnicki MA (2015) Satellite cells and skeletal muscle regeneration. Compr Physiol 5(3):1027–1059

Article  PubMed  Google Scholar 

Esteves AR, Palma AM, Gomes R, Santos D, Silva DF, Cardoso SM (2019) Acetylation as a major determinant to microtubule-dependent autophagy: relevance to Alzheimer’s and Parkinson disease pathology. Biochimica et Biophysica Acta (BBA) 1865(8):2008–2023

Article  CAS  Google Scholar 

Fiacco E, Castagnetti F, Bianconi V, Madaro L, De Bardi M, Nazio F et al (2016) Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles. Cell Death Differ 23(11):1839–1849

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Prat L, Martinez-Vicente M, Perdiguero E, Ortet L, Rodriguez-Ubreva J, Rebollo E et al (2016) Autophagy maintains stemness by preventing senescence. Nature 529(7584):37–42

Article  CAS  PubMed  Google Scholar 

Hammond JW, Cai D, Verhey KJ (2008) Tubulin modifications and their cellular functions. Curr Opin Cell Biol 20(1):71–76

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A et al (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417(6887):455–458

Article  CAS  PubMed  Google Scholar 

Jahreiss L, Menzies FM, Rubinsztein DC (2008) The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 9(4):574–587

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura S, Noda T, Yoshimori T (2008) Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct 33(1):109–122

Article  CAS  PubMed  Google Scholar 

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S et al (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. ;17(1):1-382

Kochl R, Hu XW, Chan EY, Tooze SA (2006) Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 7(2):129–145

Article  CAS  PubMed  Google Scholar 

L’Hernault SW, Rosenbaum JL (1985) Chlamydomonas alpha-tubulin is posttranslationally modified by acetylation on the epsilon-amino group of a lysine. Biochemistry 24(2):473–478

Article  PubMed  Google Scholar 

Magiera MM, Singh P, Gadadhar S, Janke C (2018) Tubulin posttranslational modifications and emerging links to human disease. Cell 173(6):1323–1327

Article  CAS  PubMed  Google Scholar 

Nichenko AS, Southern WM, Tehrani KF, Qualls AE, Flemington AB, Mercer GH et al (2020) Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice. Am J Physiol Cell Physiol 318(2):C242–C52

Article  CAS  PubMed  Google Scholar 

North BJ, Marshall BL, Borra MT, Denu JM, Verdin E (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell 11(2):437–444

Article  CAS  PubMed  Google Scholar 

Phadwal K, Kurian D, Salamat MKF, MacRae VE, Diack AB, Manson JC (2018) Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates. Sci Rep 8(1):10004

Article  PubMed  PubMed Central  Google Scholar 

Rahman FA, Baechler BL, Quadrilatero J (2024) Key considerations for investigating and interpreting autophagy in skeletal muscle. Autophagy 20(10):2121–2132

Article  PubMed  PubMed Central  Google Scholar 

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O’Kane CJ et al (2005) Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet 37(7):771–776

Article  CAS  PubMed  Google Scholar 

Reed NA, Cai D, Blasius TL, Jih GT, Meyhofer E, Gaertig J et al (2006) Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol 16(21):2166–2172

Article  CAS  PubMed  Google Scholar 

Saera-Vila A, Kish PE, Louie KW, Grzegorski SJ, Klionsky DJ, Kahana A (2016) Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration. Autophagy 12(10):1864–1875

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV (2010) The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc Natl Acad Sci U S A 107(50):21517–21522

Article  CAS  PubMed  PubMed Central