Arjmand S, Vadstrup Pedersen M, Silva NR, Landau AM, Joca S, Wegener G (2023) Sex and estrous cycle are not mediators of S-Ketamine’s rapid-antidepressant behavioral effects in a genetic rat model of depression. Int J Neuropsychopharmacol 26(5):350–358. https://doi.org/10.1093/ijnp/pyad016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475(7354):91–95. https://doi.org/10.1038/nature10130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47(4):351–354. https://doi.org/10.1016/S0006-3223(99)00230-9

Article  CAS  PubMed  Google Scholar 

Carrier N, Kabbaj M (2013) Sex differences in the antidepressant-like effects of ketamine. Neuropharmacology 70:27–34. https://doi.org/10.1016/j.neuropharm.2012.12.009

Article  CAS  PubMed  Google Scholar 

Cohen J (1988) Statistical Power Analysis for the Behavioral Sciences, 2nd ed. Lawrence Erlbaum Associates

Google Scholar 

Duman RS, Aghajanian GK, Sanacora G, Krystal JH (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22(3):238–249. https://doi.org/10.1038/nm.4050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacko D, Schaaf K, Masur L, Windoffer H, Aussieker T, Schiffer T, Zacher J, Bloch W, Gehlert S (2022) Repeated and interrupted resistance exercise induces the desensitization and re-sensitization of mTOR-related signaling in human skeletal muscle fibers. Int J Mol Sci 23(10):5431

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jelen LA, Young AH, Stone JM (2021) Ketamine: a tale of two enantiomers. J Psychopharmacol 35(2):109–123. https://doi.org/10.1177/0269881120959644

Article  CAS  PubMed  Google Scholar 

Kim J, Kundu M, Viollet B, Guan K-L (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132–141. https://doi.org/10.1038/ncb2152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krystal JH, Kavalali ET, Monteggia LM (2024) Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 49(1):41–50. https://doi.org/10.1038/s41386-023-01629-w

Article  PubMed  Google Scholar 

Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329(5994):959–964. https://doi.org/10.1126/science.1190287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Liu R-J, Dwyer JM, Banasr M, Lee B, Son H, Li X-Y, Aghajanian G, Duman RS (2011) Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69(8):754–761. https://doi.org/10.1016/j.biopsych.2010.12.015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matveychuk D, Thomas RK, Swainson J, Khullar A, MacKay MA, Baker GB, Dursun SM (2020) Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers. Ther Adv Psychopharmacol 10:2045125320916657. https://doi.org/10.1177/2045125320916657

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E, Hall BJ (2014) GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. Elife 3:e03581. https://doi.org/10.7554/eLife.03581

Article  PubMed  PubMed Central  Google Scholar 

Møller AB, Vendelbo MH, Christensen B, Clasen BF, Bak AM, Jørgensen JOL, Møller N, Jessen N (2015) Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle. J Appl Physiol 118(8):971–979. https://doi.org/10.1152/japplphysiol.01116.2014

Article  CAS  PubMed  Google Scholar 

Motulsky HJ, Brown RE (2006) Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate. BMC Bioinformatics 7:123. https://doi.org/10.1186/1471-2105-7-123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Overstreet DH, Wegener G (2013) The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing. Pharmacol Rev 65(1):143–155. https://doi.org/10.1124/pr.111.005397

Article  CAS  PubMed  Google Scholar 

Overstreet DH, Friedman E, Mathé AA, Yadid G (2005) The Flinders sensitive line rat: a selectively bred putative animal model of depression. Neurosci Biobehav Rev 29(4–5):739–759. https://doi.org/10.1016/j.neubiorev.2005.03.015

Article  CAS  PubMed  Google Scholar 

Paul RK, Singh NS, Khadeer M, Moaddel R, Sanghvi M, Green CE, O’Loughlin K, Torjman MC, Bernier M, Wainer IW (2014) (R,S)-ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function. Anesthesiology 121(1):149–159. https://doi.org/10.1097/aln.0000000000000285

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rose AJ, Broholm C, Kiillerich K, Finn SG, Proud CG, Rider MH, Richter EA, Kiens B (2005) Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol 569(Pt 1):223–228. https://doi.org/10.1113/jphysiol.2005.097154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxton RA, Sabatini DM (2017) mTOR signaling in growth, metabolism, and disease. Cell 168(6):960–976. https://doi.org/10.1016/j.cell.2017.02.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silote GP, Gatto MC, Eskelund A, Guimarães FS, Wegener G, Joca SRL (2021) Strain-, sex-, and time-dependent antidepressant-like effects of cannabidiol. Pharmaceuticals (Basel). https://doi.org/10.3390/ph14121269

Article  PubMed  PubMed Central  Google Scholar 

Slattery DA, Cryan JF (2012) Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc 7(6):1009–1014. https://doi.org/10.1038/nprot.2012.044

Article  CAS  PubMed  Google Scholar 

Spiering BA, Kraemer WJ, Anderson JM, Armstrong LE, Nindl BC, Volek JS, Maresh CM (2008) Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Med 38(7):527–540. https://doi.org/10.2165/00007256-200838070-00001

Article  PubMed  Google Scholar 

Sutton MA, Taylor AM, Ito HT, Pham A, Schuman EM (2007) Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis. Neuron 55(4):648–661. https://doi.org/10.1016/j.neuron.2007.07.030

Article  CAS  PubMed  Google Scholar 

Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA, Rennie MJ (2008) Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586(15):3701–3717. https://doi.org/10.1113/jphysiol.2008.153916

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang C, Hu YM, Zhou ZQ, Zhang GF, Yang JJ (2013) Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test. Ups J Med Sci 118(1):3–8. https://doi.org/10.3109/03009734.2012.724118