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Endocytic myosin-1 is a force-insensitive, power-generating motor
Pedersen, Snoberger et al. measure the force sensitivity of the yeast endocytic myosin-1 called Myo5 and find that it is m...
Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis
Lin et al. report that Tejas, an essential component of piRNA pathway, plays a key role in recruiting Vasa (Vas) and Spind...
NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
It is unclear whether and how mitochondrial fusion is selected. In this work, Su et al. demonstrate that NME3 functions as...
The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules
Henkin, Brito, et al. reconstitute in vitro a functional module elucidating previously poorly understood mechanisms of pol...
Mitochondrial double membrane fission: A mystery solved?
Westermann discusses two related studies examining a novel protein that plays a key role in mitochondrial division.
Nanoscale architect: Illuminating the key organizer of the fruit fly’s sensory world
Lu and Gelfand preview work from Song et al., which reveals a role for the microtubule-binding protein DCX-EMAP in the 3D ...
Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes
Zhu et al. use Drosophila gentics and cell imaging to show that different types of γ-tubulin complexes can be recruited to...
Correction: Netrins and neogenin promote myotube formation
Vol. 167, No. 3 | https://doi.org/10.1083/jcb.200405039 | November 1, 2004
Competition for calnexin binding regulates secretion and turnover of misfolded GPI-anchored proteins
Misfolded GPI-APs are released from the ER to the Golgi for rapid degradation in lysosomes by the constitutively active an...
A nucleotide diphosphate kinase mediates tethering between mitochondria prior to fusion
Ikeda et al. highlight work from Su and colleagues that describes the mechanism by which NME3 and phosphatidic acid promot...
Nucleolar condensates: A cellular machinery necessary for T cell activation
Activated T cells boost ribosome production to meet their enormous protein synthesis demands. Sharma and Shaw discuss work...
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics
Spatial and temporal discontinuities in time-lapse movies frequently disrupt automation methods such as 3D object segmenta...
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity
Gallego-Paez et al. identify a previously unannotated cassette exon in the TLN1 gene that alters the mechanical properties...
PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
Chromosome alignment and segregation in mitosis are tightly regulated. This study shows that PP6 limits the activity of Au...
The exocyst complex is an essential component of the mammalian constitutive secretory pathway
Using kinetic trafficking assays, genetics, and secretomics, Pereira, Stalder et al. demonstrate the role of the exocyst c...
The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
Dynein-driven chromosome movement facilitates chromosome synapsis in prophase I of meiosis, which is essential for genetic...
Productive HIV-1 infection of tissue macrophages by fusion with infected CD4 + T cells
Mascarau et al. demonstrate the relevance of HIV-1 infection of tissue-resident macrophages by fusion with infected CD4+ T...
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
Jiménez-Moreno et al. demonstrate that human ATG8 proteins stimulate transcriptional cell stress protection via binding to...
Double-checking chromosome segregation
Maiato and Silva discuss the origin and fate of chromosome segregation errors that satisfy the spindle assembly checkpoint...
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
Kournoutis and Johansen preview work from Jiménez-Moreno and colleagues, which shows that LMX1B binds to the Atg8 family m...
Virus update for the M2 “mac-in-touch”
Naghavi previews work from Mascarau et al. identifying that heterotypic cell fusion mediates the transfer of HIV-1 from in...
Correction: Yorkie controls tube length and apical barrier integrity during airway development
Vol. 218, No. 8 | 10.1083/jcb.201809121 | July 17, 2019
Disagreement among the three musketeers of the unfolded protein response
Jipa and Juhász preview results from the lab of Tao Wang which show a surprising antagonism between two branches of the un...
GPI anchors: Regulated as needed
Aguilera-Romero and Muñiz preview work from the Kinoshita lab, which reveals that certain GPI anchor signal sequences and ...
Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization
Larsson et al. demonstrate that the large GTPase dynamin 2 does not mediate fission of caveolae from the plasma membrane a...
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side
Van den Berg et al. provide insight into the biochemical mechanisms of the assembly and maintenance of stable microtubule ...
Quality control ensures fidelity in ribosome assembly and cellular health
Melissa Parker and Katrin Karbstein review our current understanding of the quality control mechanisms governing ribosome ...
LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period
Kozar-Gillan and colleagues reveal a novel molecular pathway in node of Ranvier formation by demonstrating that LGI3/2–ADA...
Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease whose molecular etiology remains mostly enigmatic. By discover...
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
Jaffray et al. demonstrate that the arsenic-induced, SUMO and ubiquitin-mediated degradation of the PML protein and its on...
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