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Low-dose chloroquine treatment extends the lifespan of aged rats
Low-dose chloroquine treatment extends the lifespan of aged rats
Chloroquine (CQ) has long been used as an anti-malarial agent (Wellems and Plowe, 2001). Recently, CQ has also been applie...
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis
Senescence, a stable state of growth arrest, affects many physiological and pathophysiological processes, especially aging...
Correction to: Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction
Correction to: Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, 1001...
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
We are grateful to Lei Bai, Luyang Tian, Ruijun Bai, Jing Lu, Ying Yang, Xiuping Li, Shikun Ma and Lei Zhang for administr...
BMP4 preserves the developmental potential of mESCs through - and -mediated chromosomal stability safeguarding
BMP4 preserves the developmental potential of mESCs through - and -mediated chromosomal stability safeguarding
Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a subst...
A framework for the responsible reform of the 14-day rule in human embryo research
A framework for the responsible reform of the 14-day rule in human embryo research
Considering the importance of embryonic and pertinent research, the possibility of international policy adjustment, and th...
Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis
Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis
Cardiovascular disease (CVD) is the leading cause of death around the world (Truelsen...
Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer
Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer
Metformin is currently a strong candidate anti-tumor agent in multiple cancers. However, its anti-tumor effectiveness vari...
Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture
Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture
Although widely applied in treating hematopoietic malignancies, transplantation of hematopoietic stem/progenitor cells (HS...
New pathogenic insights from large animal models of neurodegenerative diseases
New pathogenic insights from large animal models of neurodegenerative diseases
Animal models are essential for investigating the pathogenesis and developing the treatment of human diseases. Identificat...
Gonadal mosaicism mediated female-biased gender control in mice
Gonadal mosaicism mediated female-biased gender control in mice
In nature or during artificial breeding, evolutionary intervention or desirable trait...
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlyin...
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation
The nucleocapsid (N) protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation, whi...
FTO stabilizes MIS12 and counteracts senescence
FTO stabilizes MIS12 and counteracts senescence
N6-methyladenosine (m6A) is an abundant epitranscriptomic modification that regulates...
Targeting papain-like protease for broad-spectrum coronavirus inhibition
Targeting papain-like protease for broad-spectrum coronavirus inhibition
The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades em...
Postnatal state transition of cardiomyocyte as a primary step in heart maturation
Postnatal state transition of cardiomyocyte as a primary step in heart maturation
Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and re...
Connecting past and present: single-cell lineage tracing
Connecting past and present: single-cell lineage tracing
Central to the core principle of cell theory, depicting cells’ history, state and fate is a fundamental goal in mode...
The early days of structural biology at the Beijing Institute of Biophysics: In memory of Professor Zhengjiong Lin (1935–2022)
The early days of structural biology at the Beijing Institute of Biophysics: In memory of Professor Zhengjiong Lin (1935–2022)
At the end of 2017, while I was cleaning my apartment in Beijing, a thin journal caug...
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